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WO2008119009A3 - Matériaux et procédés pour une production efficace d'alanine - Google Patents

Matériaux et procédés pour une production efficace d'alanine Download PDF

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Publication number
WO2008119009A3
WO2008119009A3 PCT/US2008/058410 US2008058410W WO2008119009A3 WO 2008119009 A3 WO2008119009 A3 WO 2008119009A3 US 2008058410 W US2008058410 W US 2008058410W WO 2008119009 A3 WO2008119009 A3 WO 2008119009A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugars
alanine
efficient
materials
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/058410
Other languages
English (en)
Other versions
WO2008119009A2 (fr
WO2008119009A4 (fr
Inventor
Xueli Zhang Zhang
Kaemwich Jantama
Jonathan C Moore
Keelnatham T Shanmugam
Lonnie O'neal Ingram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of WO2008119009A2 publication Critical patent/WO2008119009A2/fr
Publication of WO2008119009A3 publication Critical patent/WO2008119009A3/fr
Publication of WO2008119009A4 publication Critical patent/WO2008119009A4/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des micro-organismes génétiquement modifiés qui produisent de la L-alanine comme produit de fermentation primaire à partir de sucres. Des sucres de pentose, tels que le xylose, et des sucres d'hexose, tels que le glucose, peuvent être efficacement fermentés en L-alanine. Les souches décrites ici ont la capacité de métaboliser tous les sucres qui constituent la biomasse lignocellulosique et une variété de disaccharides, y compris le lactose, le maltose, le saccharose et d'autres.
PCT/US2008/058410 2007-03-27 2008-03-27 Matériaux et procédés pour une production efficace d'alanine Ceased WO2008119009A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90823407P 2007-03-27 2007-03-27
US60/908,234 2007-03-27

Publications (3)

Publication Number Publication Date
WO2008119009A2 WO2008119009A2 (fr) 2008-10-02
WO2008119009A3 true WO2008119009A3 (fr) 2009-02-26
WO2008119009A4 WO2008119009A4 (fr) 2009-04-16

Family

ID=39789270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/058410 Ceased WO2008119009A2 (fr) 2007-03-27 2008-03-27 Matériaux et procédés pour une production efficace d'alanine

Country Status (1)

Country Link
WO (1) WO2008119009A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044210A2 (fr) 2002-11-06 2004-05-27 University Of Florida Materiaux et procedes permettant une bonne production d'acetate et d'autres produits
CA2688938C (fr) 2007-03-20 2018-01-16 University Of Florida Research Foundation, Inc. Matieres et procedes pour une production efficace de succinate et de malate
US8993287B2 (en) 2008-11-18 2015-03-31 University Of Florida Research Foundation, Inc. Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products
CN102803470A (zh) 2009-04-02 2012-11-28 佛罗里达大学研究基金会公司 针对生产琥珀酸路径的工程方法
CN101974476A (zh) * 2010-08-31 2011-02-16 安徽华恒生物工程有限公司 一种高产l-丙氨酸的xz-a26菌株及构建方法与应用
CN103045528B (zh) * 2012-12-28 2014-05-07 安徽华恒生物工程有限公司 生产dl-丙氨酸的工程菌及利用该工程菌生产dl-丙氨酸的方法
WO2014100920A1 (fr) * 2012-12-28 2014-07-03 安徽华恒生物工程有限公司 Production de bactéries génétiquement modifiées dl-alanine et son procédé de mise en oeuvre
BR112016002105A2 (pt) * 2013-08-30 2017-08-29 Basf Se Microrganismo modificado, método para produzir alanina e uso de um microrganismo modificado
KR20210133323A (ko) * 2013-12-13 2021-11-05 바스프 에스이 정밀 화학물질의 개선된 생산을 위한 재조합 미생물
CN106574254A (zh) * 2014-04-30 2017-04-19 赢创德固赛有限公司 使用嗜碱性细菌生产l‑氨基酸的方法
EP3271467A1 (fr) 2015-03-18 2018-01-24 Basf Se Micro-organisme recombinant pour la production améliorée de produits chimiques fins
CN104774790B (zh) * 2015-04-03 2020-11-06 江南大学 一种高效发酵生产l-丙氨酸的大肠杆菌
US10519474B2 (en) 2015-06-04 2019-12-31 Basf Se Recombinant microorganism for improved production of fine chemicals
KR20180011324A (ko) 2015-06-12 2018-01-31 바스프 에스이 알라닌의 개선된 제조를 위한 재조합 미생물
CN110904062B (zh) * 2018-09-18 2022-03-15 安徽华恒生物科技股份有限公司 一株高产l-丙氨酸的菌株
CN110982857A (zh) * 2019-09-23 2020-04-10 安徽丰原生物化学股份有限公司 一种l-丙氨酸的发酵生产方法
CN113278655B (zh) * 2020-05-13 2022-05-17 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组微生物及构建方法、应用
CN115960941A (zh) * 2021-10-08 2023-04-14 安徽丰原生物技术股份有限公司 一种生产dl-丙氨酸的基因工程菌株及其构建方法和应用
CN115960942A (zh) * 2021-10-08 2023-04-14 安徽丰原生物技术股份有限公司 一种生产l-丙氨酸的基因工程菌株及其构建方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
US7037504B2 (en) * 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7052883B2 (en) * 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7083942B2 (en) * 2002-03-09 2006-08-01 Degussa Ag Alleles of the aceA gene from coryneform bacteria

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
US7052883B2 (en) * 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7037504B2 (en) * 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7083942B2 (en) * 2002-03-09 2006-08-01 Degussa Ag Alleles of the aceA gene from coryneform bacteria

Also Published As

Publication number Publication date
WO2008119009A2 (fr) 2008-10-02
WO2008119009A4 (fr) 2009-04-16

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