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WO2008118150A3 - Nitric oxide synthase as a marker for treatment with bioreducible prodrugs - Google Patents

Nitric oxide synthase as a marker for treatment with bioreducible prodrugs Download PDF

Info

Publication number
WO2008118150A3
WO2008118150A3 PCT/US2007/023698 US2007023698W WO2008118150A3 WO 2008118150 A3 WO2008118150 A3 WO 2008118150A3 US 2007023698 W US2007023698 W US 2007023698W WO 2008118150 A3 WO2008118150 A3 WO 2008118150A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioreducible
nitric oxide
oxide synthase
prodrugs
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/023698
Other languages
French (fr)
Other versions
WO2008118150A2 (en
Inventor
Alshad S Lalani
John G Curd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novacea Inc
Original Assignee
Novacea Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacea Inc filed Critical Novacea Inc
Publication of WO2008118150A2 publication Critical patent/WO2008118150A2/en
Publication of WO2008118150A3 publication Critical patent/WO2008118150A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed is a method for preventing, treating or ameliorating hyperproliferative disorders and other conditions characterized by elevated levels of nitric oxide synthase, comprising administering a bioreducible prodrug.
PCT/US2007/023698 2006-11-10 2007-11-13 Nitric oxide synthase as a marker for treatment with bioreducible prodrugs Ceased WO2008118150A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86533306P 2006-11-10 2006-11-10
US60/865,333 2006-11-10

Publications (2)

Publication Number Publication Date
WO2008118150A2 WO2008118150A2 (en) 2008-10-02
WO2008118150A3 true WO2008118150A3 (en) 2008-11-20

Family

ID=39789146

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023698 Ceased WO2008118150A2 (en) 2006-11-10 2007-11-13 Nitric oxide synthase as a marker for treatment with bioreducible prodrugs

Country Status (1)

Country Link
WO (1) WO2008118150A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050101775A1 (en) * 1999-09-08 2005-05-12 Erion Mark D. Prodrugs for liver specific drug delivery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050101775A1 (en) * 1999-09-08 2005-05-12 Erion Mark D. Prodrugs for liver specific drug delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RIDDICK ET AL.: "Cancer Chemotherapy And Drug Metabolism.", DRUG METABOLISM AND DISPOSITION., vol. 33, no. 8, August 2005 (2005-08-01), pages 1083 - 1096, XP055354369 *
THOMSEN ET AL.: "Role of nitric oxide in tumour progression: Lessons from human tumours.", CANCER AND METASTASIS REVIEWS., vol. 17, February 1998 (1998-02-01), pages 107 - 118, XP055354371 *

Also Published As

Publication number Publication date
WO2008118150A2 (en) 2008-10-02

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