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WO2008115561A3 - Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents - Google Patents

Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents Download PDF

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Publication number
WO2008115561A3
WO2008115561A3 PCT/US2008/003705 US2008003705W WO2008115561A3 WO 2008115561 A3 WO2008115561 A3 WO 2008115561A3 US 2008003705 W US2008003705 W US 2008003705W WO 2008115561 A3 WO2008115561 A3 WO 2008115561A3
Authority
WO
WIPO (PCT)
Prior art keywords
microtubule
biomarkers
methods
stabilizing agents
determining sensitivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/003705
Other languages
French (fr)
Other versions
WO2008115561A2 (en
Inventor
Shujian Wu
Scott D Chasalow
Hyerim Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of WO2008115561A2 publication Critical patent/WO2008115561A2/en
Publication of WO2008115561A3 publication Critical patent/WO2008115561A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.
PCT/US2008/003705 2007-03-21 2008-03-21 Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents Ceased WO2008115561A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91933907P 2007-03-21 2007-03-21
US60/919,339 2007-03-21

Publications (2)

Publication Number Publication Date
WO2008115561A2 WO2008115561A2 (en) 2008-09-25
WO2008115561A3 true WO2008115561A3 (en) 2008-11-20

Family

ID=39592075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/003705 Ceased WO2008115561A2 (en) 2007-03-21 2008-03-21 Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents

Country Status (1)

Country Link
WO (1) WO2008115561A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022251421A1 (en) * 2021-05-27 2022-12-01 Mayo Foundation For Medical Education And Research Methods and materials for treating proteinopathies

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051978A1 (en) * 2000-02-17 2002-05-02 Roth Frederick P. Methods and compositions for the identification, assessment, prevention and therapy of human cancers
US20030134315A1 (en) * 1998-02-18 2003-07-17 Warenius Hilmar Meek Treating cancer
WO2004111603A2 (en) * 2003-05-28 2004-12-23 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
WO2006052731A2 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
WO2006052862A1 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
US20060121511A1 (en) * 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
WO2006061216A2 (en) * 2004-12-10 2006-06-15 Bayer Healthcare Ag Genetic alteration useful for the response prediction of malignant neoplasia to taxane-based medical treatment
US20070172844A1 (en) * 2005-09-28 2007-07-26 University Of South Florida Individualized cancer treatments
US20070190544A1 (en) * 2005-10-28 2007-08-16 Emory University Methods of screening for resistance to microtuble-targeting drugs
WO2007117439A2 (en) * 2006-03-31 2007-10-18 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030134315A1 (en) * 1998-02-18 2003-07-17 Warenius Hilmar Meek Treating cancer
US20020051978A1 (en) * 2000-02-17 2002-05-02 Roth Frederick P. Methods and compositions for the identification, assessment, prevention and therapy of human cancers
WO2004111603A2 (en) * 2003-05-28 2004-12-23 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
US20050064455A1 (en) * 2003-05-28 2005-03-24 Baker Joffre B. Gene expression markers for predicting response to chemotherapy
US20060166230A1 (en) * 2004-11-05 2006-07-27 Baker Joffre B Predicting response to chemotherapy using gene expression markers
WO2006052862A1 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
US20060166231A1 (en) * 2004-11-05 2006-07-27 Joffre Baker Molecular indicators of breast cancer prognosis and prediction of treatment response
WO2006052731A2 (en) * 2004-11-05 2006-05-18 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
US20060121511A1 (en) * 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
WO2006061216A2 (en) * 2004-12-10 2006-06-15 Bayer Healthcare Ag Genetic alteration useful for the response prediction of malignant neoplasia to taxane-based medical treatment
US20070172844A1 (en) * 2005-09-28 2007-07-26 University Of South Florida Individualized cancer treatments
US20070190544A1 (en) * 2005-10-28 2007-08-16 Emory University Methods of screening for resistance to microtuble-targeting drugs
WO2007117439A2 (en) * 2006-03-31 2007-10-18 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALTMANN KARL-HEINZ: "Microtubule-stabilizing agents: A growing class of important anticancer drugs", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 5, no. 4, 1 August 2001 (2001-08-01), pages 424 - 431, XP002428918, ISSN: 1367-5931 *
AYERS M ET AL: "GENE EXPRESSION PROFILES PREDUCT COMPLETE PATHOLOGIC RESPONSE TO NEOADJUVANT PACLITAXEL AND FLUOROURACIL, DOXORUBICIN, AND CYCLOPHOSPHAMIDE CHEMOTHERAPY IN BREAST CANCER", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, vol. 22, no. 12, 15 June 2004 (2004-06-15), pages 2284 - 2293, XP009044161, ISSN: 0732-183X *
LEO DI A ET AL: "Predictive molecular markers in the adjuvant therapy of breast cancer: state of the art in the year 2002", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, CHURCHILL LIVINGSTONE JAPAN, TOKYO, GB, vol. 7, no. 4, 1 August 2002 (2002-08-01), pages 245 - 253, XP002354945, ISSN: 1341-9625 *

Also Published As

Publication number Publication date
WO2008115561A2 (en) 2008-09-25

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