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WO2008112990A3 - Méthodes de diagnostic et de traitement de la maladie de crohn - Google Patents

Méthodes de diagnostic et de traitement de la maladie de crohn Download PDF

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Publication number
WO2008112990A3
WO2008112990A3 PCT/US2008/057028 US2008057028W WO2008112990A3 WO 2008112990 A3 WO2008112990 A3 WO 2008112990A3 US 2008057028 W US2008057028 W US 2008057028W WO 2008112990 A3 WO2008112990 A3 WO 2008112990A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
crohn
locus
methods
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/057028
Other languages
English (en)
Other versions
WO2008112990A2 (fr
Inventor
Jerome I Rotter
Kent D Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of WO2008112990A2 publication Critical patent/WO2008112990A2/fr
Publication of WO2008112990A3 publication Critical patent/WO2008112990A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une méthode de diagnostic ou de prédiction de la susceptibilité à la maladie de Crohn (MC) chez un individu, par détermination de la présence ou de l'absence de variants associés à un risque génétique. Dans un mode de mise en oeuvre, cette méthode consiste à déterminer en outre la présence ou l'absence d'un variant à risque au niveau du locus ATG1GL1, du locus PHOX2B, du gène NCF4, de l'intron 4 du locus FAM92B, et/ou de la région intergénique sur 10q21.1. Les méthodes décrites peuvent être utilisées pour diagnostiquer ou prédire la susceptibilité à un sous-type clinique de la maladie de Crohn, par exemple la maladie de Crohn iléale, un sous-type caractérisé par une atteinte de la région iléale de l'intestin grêle.
PCT/US2008/057028 2007-03-15 2008-03-14 Méthodes de diagnostic et de traitement de la maladie de crohn Ceased WO2008112990A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89506807P 2007-03-15 2007-03-15
US60/895,068 2007-03-15

Publications (2)

Publication Number Publication Date
WO2008112990A2 WO2008112990A2 (fr) 2008-09-18
WO2008112990A3 true WO2008112990A3 (fr) 2008-12-11

Family

ID=39760419

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/057028 Ceased WO2008112990A2 (fr) 2007-03-15 2008-03-14 Méthodes de diagnostic et de traitement de la maladie de crohn

Country Status (1)

Country Link
WO (1) WO2008112990A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062960A2 (fr) * 2008-11-26 2010-06-03 Cedars-Sinai Medical Center Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
WO2014160883A1 (fr) 2013-03-27 2014-10-02 Cedars-Sinai Medical Center Traitement de la fibrose et de l'inflammation par inhibition de tl1a
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
KR102464372B1 (ko) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Business Wire", Retrieved from the Internet <URL:http://www.findarticles.com/p/articles/mi_m0EIN/is_2007_Jan_24/ai_n27122450> *
BECKER K.G. ET AL.: "Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases", PNAS, vol. 95, August 1998 (1998-08-01), pages 9979 - 9984, XP002960579 *

Also Published As

Publication number Publication date
WO2008112990A2 (fr) 2008-09-18

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