[go: up one dir, main page]

WO2008109110A3 - Système de régulation de la pression sanguine - Google Patents

Système de régulation de la pression sanguine Download PDF

Info

Publication number
WO2008109110A3
WO2008109110A3 PCT/US2008/002938 US2008002938W WO2008109110A3 WO 2008109110 A3 WO2008109110 A3 WO 2008109110A3 US 2008002938 W US2008002938 W US 2008002938W WO 2008109110 A3 WO2008109110 A3 WO 2008109110A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood pressure
regulating blood
qtl
partially
evaluating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/002938
Other languages
English (en)
Other versions
WO2008109110A2 (fr
Inventor
Bina Joe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toledo
Original Assignee
University of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toledo filed Critical University of Toledo
Publication of WO2008109110A2 publication Critical patent/WO2008109110A2/fr
Publication of WO2008109110A3 publication Critical patent/WO2008109110A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un système destiné à évaluer un locus à caractère quantitatif (QTL) ou un fragment fonctionnel dérivé de celui-ci, le QTL contrôlant au moins partiellement la pression sanguine et/ou étant au moins partiellement indicatif d'une possibilité de développer de l'hypertension.
PCT/US2008/002938 2007-03-06 2008-03-05 Système de régulation de la pression sanguine Ceased WO2008109110A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90518607P 2007-03-06 2007-03-06
US60/905,186 2007-03-06

Publications (2)

Publication Number Publication Date
WO2008109110A2 WO2008109110A2 (fr) 2008-09-12
WO2008109110A3 true WO2008109110A3 (fr) 2008-12-11

Family

ID=39738985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/002938 Ceased WO2008109110A2 (fr) 2007-03-06 2008-03-05 Système de régulation de la pression sanguine

Country Status (1)

Country Link
WO (1) WO2008109110A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708664B2 (en) 2012-04-20 2017-07-18 University Of Virginia Patent Foundation Compositions and methods for identifying and diagnosing salt sensitivity of blood pressure
CN114636774B (zh) * 2022-04-22 2024-05-17 苏州市疾病预防控制中心 一种预测青少年高血压患病风险的生物代谢标志物组合物

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CAL S. ET AL.: "Cloning, Expression Analysis, and Structural Characterization of Seven Novel Human ADAMTSs, a Family of Metalloproteinases with Disintegrin and Thrombospondin-1 Domains", GENE, vol. 283, 2002, pages 49 - 62, XP002207625 *
GARRETT M. ET AL.: "Identification of Blood Pressure Quantitative Trait Loci that Differentiate Tow Hypersensitive Strains", JOURNAL OF HYPERTENSION, vol. 20, 2002, pages 2399 - 2406 *
GOERTSCHES R. ET AL.: "Genetic Association Between Polymorphisms in the ADAMTS14 Gene and Multiple Sclerosis", JOURNAL OF NEUROIMMUNOLOGY, vol. 164, 2005, pages 140 - 147, XP004941875 *
HILLS C. ET AL.: "Cri du Chat Syndrome and Congential Heart Disease: A Review of Previously Reported Cases and Presentation of an Additional 21 Cases From the Pediatric Cardiac Care Consortium", PEDIATRICS, vol. 117, May 2006 (2006-05-01), pages E924 - E927 *
JONES G.C. ET AL.: "ADAMTS Proteinases: a Multi-Domain, Multi-Functional Family with Roles in Extracellular Matrix Turnover and Arthritis", ARTHRITIS RESEARCH AND THERAPY, vol. 7, 2005, pages 160 - 169, XP009058555 *
SANADA H. ET AL.: "Single-Nucleotide Polymorphisms for Diagnosis of Salt-Sensitive Hypertension", CLINICAL CHEMISTRY, vol. 52, 2006, pages 1 - 9 *
ST. LEZIN E. ET AL.: "Effect of Renin Gene Transfer on Blood Pressure in the Spontaneously Hypersensitive Rat", HYPERTENSION, vol. 31, no. PART 2, 1998, pages 373 - 377 *
SUGIYAMA F. ET AL.: "Concordance of Murine Quantitative Trait Loci for Salt-Induced Hypertension with Rat and Human Loci", GENOMICS, vol. 71, 2001, pages 7077 *
WILSON T.W. ET AL.: "Effects of Lipid-Lowering Agents in the Dahl Salt-Sensitive Rat", HYPERTENSION, no. PART 3, 1998, pages 225 - 231 *

Also Published As

Publication number Publication date
WO2008109110A2 (fr) 2008-09-12

Similar Documents

Publication Publication Date Title
WO2007047408A3 (fr) Application de signature promac
PT1949285T (pt) Sistemas e métodos para tratamento, diagnóstico e previsão da ocorrência de uma condição médica
WO2011107482A3 (fr) Méthode de diagnostic de l'obésité
WO2006020269A3 (fr) Biomarqueurs de maladie neurodegenerative
WO2009059800A3 (fr) Instruments pour exécuter une procédure opératoire sur une articulation
WO2009021754A3 (fr) Anticorps monospécifiques et multispécifiques, et procédés d'utilisation
WO2008084331A3 (fr) Biomarqeurs pour des troubles rénaux
WO2007081720A3 (fr) Procédés et compositions basés sur des micro-arn et s'appliquant au diagnostic, au pronostic et au traitement du cancer du poumon
WO2007106762A3 (fr) Biomarqueurs de la maladie d'alzheimer et méthodes d'utilisation
WO2007045197A3 (fr) Profils d'expression destines a la prevision d'etats septiques
WO2007053702A3 (fr) Synthese de nucleotides fluorescents photoclivables a modification 3'-o-allyl en quadrichromie et procedes associes
WO2007044763A3 (fr) Systeme et procede permettant la detection de transactions frauduleuses
WO2007100919A8 (fr) Marqueurs pour l'accoutumance
WO2005065365A3 (fr) Systemes et procede pour l'amelioration esthetique
WO2009007649A3 (fr) Dispositif et procede d'identification et de determination de groupes sanguins
WO2007141258A3 (fr) Méthode pour diagnostic précoce de rétinopathie diabétique proliférative
WO2007101063A3 (fr) Traitement de troubles liés au développement
WO2008115710A3 (fr) Biomarqueurs pour le cancer
WO2008109110A3 (fr) Système de régulation de la pression sanguine
WO2004045376A3 (fr) Methodes de criblage permettant d'identifier des traitements contre une maladie auto-immune
EA200702193A1 (ru) Гликозилирование белков
WO2008115517A3 (fr) Méthodes d'identification de cellules souches par détection de l'autofluorescence des cellules et du syncytium
WO2005026392A3 (fr) Compositions, reactifs, et kits et procede de diagnostic, de controle et de traitement de l'obesite et/ou du diabete
WO2008143944A3 (fr) Procédés de glycosylation et bioconjugaison
WO2006138219A3 (fr) Procedes d'evaluation de patients

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08742025

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08742025

Country of ref document: EP

Kind code of ref document: A2