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WO2008108927A3 - Procédés et compositions de stabilisation de polypeptides - Google Patents

Procédés et compositions de stabilisation de polypeptides Download PDF

Info

Publication number
WO2008108927A3
WO2008108927A3 PCT/US2008/002261 US2008002261W WO2008108927A3 WO 2008108927 A3 WO2008108927 A3 WO 2008108927A3 US 2008002261 W US2008002261 W US 2008002261W WO 2008108927 A3 WO2008108927 A3 WO 2008108927A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
stabilizing polypeptides
stabilizing
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/002261
Other languages
English (en)
Other versions
WO2008108927A2 (fr
Inventor
Gabriel Sosne
David Crockford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RegeneRx Biopharmaceuticals Inc
Original Assignee
RegeneRx Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RegeneRx Biopharmaceuticals Inc filed Critical RegeneRx Biopharmaceuticals Inc
Publication of WO2008108927A2 publication Critical patent/WO2008108927A2/fr
Publication of WO2008108927A3 publication Critical patent/WO2008108927A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé de stabilisation d'un polypeptide à l'extérieur d'un corps combinant le polypeptide à une solution aqueuse qui inclut des niveaux pratiquement physiologiques d'électrolytes et de sels.
PCT/US2008/002261 2007-03-06 2008-02-21 Procédés et compositions de stabilisation de polypeptides Ceased WO2008108927A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90505107P 2007-03-06 2007-03-06
US60/905,051 2007-03-06

Publications (2)

Publication Number Publication Date
WO2008108927A2 WO2008108927A2 (fr) 2008-09-12
WO2008108927A3 true WO2008108927A3 (fr) 2008-12-04

Family

ID=39738962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/002261 Ceased WO2008108927A2 (fr) 2007-03-06 2008-02-21 Procédés et compositions de stabilisation de polypeptides

Country Status (1)

Country Link
WO (1) WO2008108927A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
EP3210614A4 (fr) * 2014-10-22 2018-06-13 G-Treebnt Co., Ltd. Composition contenant de la thymosine bêta 4 et formulation pharmaceutique la contenant
US9867868B2 (en) * 2015-08-18 2018-01-16 G-Treebnt Co., Ltd. Pharmaceutical composition for treating or preventing corneal wound comprising thymosin β4 and citric acid
WO2017061663A1 (fr) * 2015-10-06 2017-04-13 주식회사 지트리비앤티 Procédé de préparation de préparation ophtalmique contenant de la thymosine bêta-4
KR102115158B1 (ko) * 2016-11-29 2020-05-26 주식회사 지트리파마슈티컬 티모신 베타 4 를 함유하는 제형
KR102340750B1 (ko) 2017-03-03 2021-12-21 에이치엘비테라퓨틱스 주식회사 티모신 베타 4를 유효성분으로 포함하는 안정화된 외용 제제
IT201900000561A1 (it) * 2019-01-14 2020-07-14 Medivis S R L Formulazioni topiche oftalmiche chimicamente e fisicamente stabili a base di Nepafenac
GB201916379D0 (en) * 2019-11-11 2019-12-25 Biocrucible Ltd Biochemical reaction methods and reagents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHI E.Y. ET AL.: "Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation", PHARM. RES., vol. 20, no. 9, September 2003 (2003-09-01), pages 1325 - 1336, XP002475010 *
GOLDSTEIN A.L. ET AL.: "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues", TRENDS IN MOLECULAR MEDICINE, vol. 11, no. 9, September 2005 (2005-09-01), pages 421 - 429, XP005065335 *
PHILP D. ET AL.: "Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice in aged mice", WOUND REPAIR AND REGENERATION, vol. 11, no. 1, January 2003 (2003-01-01) - February 2003 (2003-02-01), pages 19 - 24, XP002441696 *
WANG W. ET AL.: "Antibody Structure, Instability, and Formulation", J. PHARM. SCI., vol. 96, no. 1, January 2007 (2007-01-01), pages 1 - 26, XP009084505 *

Also Published As

Publication number Publication date
WO2008108927A2 (fr) 2008-09-12

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