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WO2008106979A3 - Pharmaceutical compositions comprising flavonoids and xylitol - Google Patents

Pharmaceutical compositions comprising flavonoids and xylitol Download PDF

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Publication number
WO2008106979A3
WO2008106979A3 PCT/DK2008/050051 DK2008050051W WO2008106979A3 WO 2008106979 A3 WO2008106979 A3 WO 2008106979A3 DK 2008050051 W DK2008050051 W DK 2008050051W WO 2008106979 A3 WO2008106979 A3 WO 2008106979A3
Authority
WO
WIPO (PCT)
Prior art keywords
flavonoids
xylitol
pharmaceutical compositions
relates
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2008/050051
Other languages
French (fr)
Other versions
WO2008106979A2 (en
Inventor
Kurt Berg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMMUPHARM AS
Original Assignee
IMMUPHARM AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMMUPHARM AS filed Critical IMMUPHARM AS
Publication of WO2008106979A2 publication Critical patent/WO2008106979A2/en
Publication of WO2008106979A3 publication Critical patent/WO2008106979A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention relates to use of certain sugar alcohols for reduction of viruses, in particular vira causing common cold. In one embodiment, the invention relates to pharmaceutical compositions comprising a sugar alcohol, preferably xylitol. Said compositions preferably also comprise one or more flavonoids. Said composition is preferably formulated as a chewing gum. The invention also relates to treatment of common cold using said compositions.
PCT/DK2008/050051 2007-03-02 2008-02-29 Pharmaceutical compositions comprising flavonoids and xylitol Ceased WO2008106979A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200700315 2007-03-02
DKPA200700315 2007-03-02

Publications (2)

Publication Number Publication Date
WO2008106979A2 WO2008106979A2 (en) 2008-09-12
WO2008106979A3 true WO2008106979A3 (en) 2009-05-07

Family

ID=39365437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2008/050051 Ceased WO2008106979A2 (en) 2007-03-02 2008-02-29 Pharmaceutical compositions comprising flavonoids and xylitol

Country Status (1)

Country Link
WO (1) WO2008106979A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010048283A1 (en) 2010-10-14 2012-04-19 Schaper & Brümmer GmbH & Co. KG Buyable tablet
CN102048726A (en) * 2011-01-10 2011-05-11 华东理工大学 Application of nobiletin
US8420617B2 (en) 2011-03-11 2013-04-16 Biocell Laboratories Multiantivirus compound, composition and method for treatment of virus diseases
CN103012348B (en) * 2012-12-19 2015-04-08 苏薇薇 6,8-substituted naringenin derivative and application thereof
KR101677855B1 (en) * 2014-08-08 2016-11-21 중앙대학교 산학협력단 Composition for preventing and treating respiratory syncytial virus (RSV) infection comprising xylitol
BR102016020391A2 (en) * 2016-09-02 2017-09-19 Abrao Saad William PHARMACEUTICAL FORMULATION BASED ON ZINC AND QUERCETIN FOR PRODUCTION OF EFFECTIVE ANTIVIRAL MEDICATION FOR DENGUE AND ZIKA
CN106667997A (en) * 2017-02-27 2017-05-17 吉林大学 EGCG with inhibitory effect on streptococcus pneumoniae pathogenicity and application
US11304968B2 (en) 2018-11-16 2022-04-19 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide
US10639294B2 (en) 2018-10-02 2020-05-05 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide metabolite
UA128422C2 (en) * 2020-05-29 2024-07-03 Ведісіналс Індіа Прайвіт Лімітед COMPOSITION FOR THE TREATMENT OF COVID-19 AND RELATED DISORDERS
US20240016777A1 (en) * 2020-11-12 2024-01-18 Beth Israel Deaconess Medical Center, Inc. Compounds and methods for treating viral infections
CN119235885B (en) * 2024-09-19 2025-11-18 广东省第二人民医院（广东省卫生应急医院） Application of rutin in anti-coxsackie virus drugs

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003165A1 (en) * 1996-07-24 1998-01-29 Leiras Oy New use of xylitol and pharmaceutical compositions therefor
WO2002009699A2 (en) * 2000-07-28 2002-02-07 Immupharm Aps Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract
WO2004037237A1 (en) * 2002-10-24 2004-05-06 Immupharm A/S Pharmaceutical compositions comprising flavonoids and menthol
US20060280700A1 (en) * 2005-06-08 2006-12-14 Isler Stuart L Oral hygiene system to fight the effects of aging on the mouth, gums, and teeth

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003165A1 (en) * 1996-07-24 1998-01-29 Leiras Oy New use of xylitol and pharmaceutical compositions therefor
WO2002009699A2 (en) * 2000-07-28 2002-02-07 Immupharm Aps Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract
WO2004037237A1 (en) * 2002-10-24 2004-05-06 Immupharm A/S Pharmaceutical compositions comprising flavonoids and menthol
US20060280700A1 (en) * 2005-06-08 2006-12-14 Isler Stuart L Oral hygiene system to fight the effects of aging on the mouth, gums, and teeth

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TURNER RONALD B ET AL: "Treatment of the common cold with troxerutin", APMIS, vol. 112, no. 9, September 2004 (2004-09-01), pages 605 - 611, XP002507369, ISSN: 0903-4641 *
VERNACCHIO ET AL: "Tolerability of oral xylitol solution in young children: Implications for otitis media prophylaxis", INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 71, no. 1, 22 December 2006 (2006-12-22), pages 89 - 94, XP005811132, ISSN: 0165-5876 *

Also Published As

Publication number Publication date
WO2008106979A2 (en) 2008-09-12

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