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WO2008105383A1 - Pyrazole derivative and use thereof for medical purposes - Google Patents

Pyrazole derivative and use thereof for medical purposes Download PDF

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Publication number
WO2008105383A1
WO2008105383A1 PCT/JP2008/053230 JP2008053230W WO2008105383A1 WO 2008105383 A1 WO2008105383 A1 WO 2008105383A1 JP 2008053230 W JP2008053230 W JP 2008053230W WO 2008105383 A1 WO2008105383 A1 WO 2008105383A1
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazole derivative
medical purposes
disclosed
pyrazole
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053230
Other languages
French (fr)
Japanese (ja)
Inventor
Yuji Sugawara
Hideyuki Tsutsui
Yasuhiro Morita
Naoki Izumimoto
Mika Morimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of WO2008105383A1 publication Critical patent/WO2008105383A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a pyrazole derivative represented by the following formula (1). Also disclosed is use of the pyrazole derivative for medical purposes. The pyrazole derivative is effective as an analgesic agent or a therapeutic or prophylactic agent for neurogenic pain.
PCT/JP2008/053230 2007-02-26 2008-02-26 Pyrazole derivative and use thereof for medical purposes Ceased WO2008105383A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-045678 2007-02-26
JP2007045678 2007-02-26

Publications (1)

Publication Number Publication Date
WO2008105383A1 true WO2008105383A1 (en) 2008-09-04

Family

ID=39721215

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053230 Ceased WO2008105383A1 (en) 2007-02-26 2008-02-26 Pyrazole derivative and use thereof for medical purposes

Country Status (1)

Country Link
WO (1) WO2008105383A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010050577A1 (en) 2008-10-31 2010-05-06 東レ株式会社 Cyclohexane derivative and pharmaceutical use thereof
WO2011125836A1 (en) 2010-03-31 2011-10-13 東レ株式会社 Therapeutic agent or prophylactic agent for fibromyalgia
WO2011125838A1 (en) 2010-03-31 2011-10-13 東レ株式会社 Therapeutic agent or preventive agent for urine collection disorder
WO2011136318A1 (en) 2010-04-28 2011-11-03 東レ株式会社 Therapeutic agent and preventative agent for alzheimer's disease
JP2014172851A (en) * 2013-03-07 2014-09-22 Chiba Univ Method for producing pyrazole derivative and method for producing isoxazole derivative
WO2015115509A1 (en) 2014-01-29 2015-08-06 東レ株式会社 Therapeutic or prophylactic agent for multiple sclerosis
CN106674084A (en) * 2016-12-20 2017-05-17 山东轩德医药科技有限公司 Preparation method of 2-isopropoxy-5-methyl-4-(piperidine-4-yl) aniline dihydrochloride
US9951025B2 (en) 2013-03-15 2018-04-24 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
US9963440B2 (en) 2010-03-30 2018-05-08 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
US10058541B2 (en) 2013-03-15 2018-08-28 Verseon Corporation Multisubstituted aromatic compounds as serine protease inhibitors
CN108863803A (en) * 2018-06-15 2018-11-23 上海华堇生物技术有限责任公司 A kind of new preparation process of 4- methoxyl group-beta-nitrostyrene
US10189810B2 (en) 2014-09-17 2019-01-29 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
US10532995B2 (en) 2015-02-27 2020-01-14 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038418A1 (en) * 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
JP2006514095A (en) * 2002-12-02 2006-04-27 アステラス製薬株式会社 Pyrazole derivative
WO2007111323A1 (en) * 2006-03-27 2007-10-04 Toray Industries, Inc. Ureide derivative and use thereof for medical purposes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038418A1 (en) * 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
JP2006514095A (en) * 2002-12-02 2006-04-27 アステラス製薬株式会社 Pyrazole derivative
WO2007111323A1 (en) * 2006-03-27 2007-10-04 Toray Industries, Inc. Ureide derivative and use thereof for medical purposes

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349874B2 (en) 2008-10-31 2013-01-08 Toray Industries, Inc. Cyclohexane derivative and pharmaceutical use thereof
WO2010050577A1 (en) 2008-10-31 2010-05-06 東レ株式会社 Cyclohexane derivative and pharmaceutical use thereof
US8247569B2 (en) 2008-10-31 2012-08-21 Toray Industries, Inc. Cyclohexane derivative and pharmaceutical use thereof
JP5522031B2 (en) * 2008-10-31 2014-06-18 東レ株式会社 Cyclohexane derivative and its pharmaceutical use
US10653674B2 (en) 2010-03-30 2020-05-19 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
US9963440B2 (en) 2010-03-30 2018-05-08 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
US8957094B2 (en) 2010-03-31 2015-02-17 Toray Industries, Inc. Therapeutic agent or prophylactic agent for fibromyalgia
KR101738471B1 (en) 2010-03-31 2017-05-22 도레이 카부시키가이샤 Therapeutic agent or prophylactic agent for fibromyalgia
EP2554541A4 (en) * 2010-03-31 2013-10-09 Toray Industries Therapeutic agent or prophylactic agent for fibromyalgia
WO2011125836A1 (en) 2010-03-31 2011-10-13 東レ株式会社 Therapeutic agent or prophylactic agent for fibromyalgia
US8642625B2 (en) 2010-03-31 2014-02-04 Toray Industries, Inc. Therapeutic agent or preventive agent for urine collection disorder
CN102812008A (en) * 2010-03-31 2012-12-05 东丽株式会社 Therapeutic agent or preventive agent for urine collection disorder
WO2011125838A1 (en) 2010-03-31 2011-10-13 東レ株式会社 Therapeutic agent or preventive agent for urine collection disorder
CN102812008B (en) * 2010-03-31 2015-01-07 东丽株式会社 Therapeutic agent or preventive agent for urine collection disorder
KR101739879B1 (en) 2010-03-31 2017-05-25 도레이 카부시키가이샤 Therapeutic agent or preventive agent for urine collection disorder
CN102822148A (en) * 2010-03-31 2012-12-12 东丽株式会社 Therapeutic agent or prophylactic agent for fibromyalgia
JP5783042B2 (en) * 2010-03-31 2015-09-24 東レ株式会社 Therapeutic or preventive agent for urinary storage disorder
WO2011136318A1 (en) 2010-04-28 2011-11-03 東レ株式会社 Therapeutic agent and preventative agent for alzheimer's disease
US8598212B2 (en) 2010-04-28 2013-12-03 Toray Industries, Inc. Therapeutic agent and preventative agent for alzheimer's disease
JP5682555B2 (en) * 2010-04-28 2015-03-11 東レ株式会社 Therapeutic or preventive agent for Alzheimer's disease
KR101739881B1 (en) 2010-04-28 2017-05-25 도레이 카부시키가이샤 Therapeutic agent and preventative agent for alzheimer's disease
JP2014172851A (en) * 2013-03-07 2014-09-22 Chiba Univ Method for producing pyrazole derivative and method for producing isoxazole derivative
US9951025B2 (en) 2013-03-15 2018-04-24 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
US10058541B2 (en) 2013-03-15 2018-08-28 Verseon Corporation Multisubstituted aromatic compounds as serine protease inhibitors
US10251872B2 (en) 2013-03-15 2019-04-09 Verseon Corporation Multisubstituted aromatic compounds as serine protease inhibitors
WO2015115509A1 (en) 2014-01-29 2015-08-06 東レ株式会社 Therapeutic or prophylactic agent for multiple sclerosis
US10189810B2 (en) 2014-09-17 2019-01-29 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
US10532995B2 (en) 2015-02-27 2020-01-14 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
CN106674084B (en) * 2016-12-20 2019-03-01 山东轩德医药科技有限公司 A kind of preparation method of 2- isopropyl oxygroup -5- methyl -4- (piperidin-4-yl) aniline dihydrochloride
CN106674084A (en) * 2016-12-20 2017-05-17 山东轩德医药科技有限公司 Preparation method of 2-isopropoxy-5-methyl-4-(piperidine-4-yl) aniline dihydrochloride
CN108863803A (en) * 2018-06-15 2018-11-23 上海华堇生物技术有限责任公司 A kind of new preparation process of 4- methoxyl group-beta-nitrostyrene

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