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WO2008155900A1 - 糖鎖付加glp-1ペプチド - Google Patents

糖鎖付加glp-1ペプチド Download PDF

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Publication number
WO2008155900A1
WO2008155900A1 PCT/JP2008/001554 JP2008001554W WO2008155900A1 WO 2008155900 A1 WO2008155900 A1 WO 2008155900A1 JP 2008001554 W JP2008001554 W JP 2008001554W WO 2008155900 A1 WO2008155900 A1 WO 2008155900A1
Authority
WO
WIPO (PCT)
Prior art keywords
glp
peptide
sugar chain
chain attached
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/001554
Other languages
English (en)
French (fr)
Inventor
Yasuhiro Kajihara
Takashi Tsuji
Izumi Sakamoto
Yuri Nambu
Kazuhiro Fukae
Katsunari Tezuka
Hiroaki Asai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Yokohama National University NUC
Yokohama City University
Original Assignee
Otsuka Chemical Co Ltd
Yokohama National University NUC
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, Yokohama National University NUC, Yokohama City University filed Critical Otsuka Chemical Co Ltd
Priority to AU2008264750A priority Critical patent/AU2008264750C1/en
Priority to EP08764149.4A priority patent/EP2172479B1/en
Priority to BRPI0813139A priority patent/BRPI0813139A8/pt
Priority to RU2010101331/10A priority patent/RU2539829C2/ru
Priority to CA2696615A priority patent/CA2696615A1/en
Priority to CN2008800253949A priority patent/CN102015761A/zh
Priority to DK08764149.4T priority patent/DK2172479T3/en
Priority to JP2009520311A priority patent/JP5646848B2/ja
Publication of WO2008155900A1 publication Critical patent/WO2008155900A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

　本発明は、GLP-1と比べて、血中半減期が長く、かつ好ましくは高い血糖値抑制活性を示す糖鎖付加GLP-1ペプチドに関する。本発明は、(a) GLP-1；(b) GLP-1において、１若しくは数個のアミノ酸が欠失、置換若しくは付加されたペプチド；又は、(c) GLP-1の類縁体；において、少なくとも１個のアミノ酸が糖鎖付加アミノ酸で置換されたことを特徴とする、GLP-1活性を有する糖鎖付加GLP-1ペプチドに関する。
PCT/JP2008/001554 2007-06-19 2008-06-17 糖鎖付加glp-1ペプチド Ceased WO2008155900A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2008264750A AU2008264750C1 (en) 2007-06-19 2008-06-17 GLP-1 peptide having sugar chain attached thereto
EP08764149.4A EP2172479B1 (en) 2007-06-19 2008-06-17 Glp-1 peptide having sugar chain attached thereto
BRPI0813139A BRPI0813139A8 (pt) 2007-06-19 2008-06-17 peptídeo glp-1 com adição de cadeia oligossacarídea
RU2010101331/10A RU2539829C2 (ru) 2007-06-19 2008-06-17 Пептид glp-1 с присоединенной олигосахаридной цепью
CA2696615A CA2696615A1 (en) 2007-06-19 2008-06-17 Oligosaccharide chain added glp-1 peptide
CN2008800253949A CN102015761A (zh) 2007-06-19 2008-06-17 附加糖链的glp-1肽
DK08764149.4T DK2172479T3 (en) 2007-06-19 2008-06-17 GLP-1 peptide having the sugar chain attached thereto
JP2009520311A JP5646848B2 (ja) 2007-06-19 2008-06-17 糖鎖付加ｇｌｐ−１ペプチド

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007160951 2007-06-19
JP2007-160951 2007-06-19

Publications (1)

Publication Number Publication Date
WO2008155900A1 true WO2008155900A1 (ja) 2008-12-24

Family

ID=40156064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001554 Ceased WO2008155900A1 (ja) 2007-06-19 2008-06-17 糖鎖付加glp-1ペプチド

Country Status (13)

Country Link
US (3) US7985731B2 (ja)
EP (1) EP2172479B1 (ja)
JP (1) JP5646848B2 (ja)
KR (1) KR20100049032A (ja)
CN (1) CN102015761A (ja)
AU (1) AU2008264750C1 (ja)
BR (1) BRPI0813139A8 (ja)
CA (1) CA2696615A1 (ja)
DK (1) DK2172479T3 (ja)
RU (1) RU2539829C2 (ja)
SG (1) SG178797A1 (ja)
TW (1) TWI423821B (ja)
WO (1) WO2008155900A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153960A1 (ja) * 2008-06-17 2009-12-23 大塚化学株式会社 糖鎖付加ｇｌｐ－１ペプチド
WO2011052523A1 (ja) * 2009-10-30 2011-05-05 大塚化学株式会社 抗原性ｇｌｐ－１アナログの糖鎖付加体
WO2012130136A1 (zh) * 2011-03-29 2012-10-04 天津药物研究院 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
WO2014080730A1 (ja) * 2012-11-22 2014-05-30 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカー部分と生理活性物質部分とを含む化合物またはその塩、及びそれらの製造方法
JPWO2012086812A1 (ja) * 2010-12-22 2014-06-05 味の素株式会社 配糖体化合物
WO2014084110A1 (ja) * 2012-11-30 2014-06-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
EP4015528A4 (en) * 2019-08-13 2023-09-20 Anygen Co., Ltd. EXENATIDE ANALOG AND ITS USE

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100049032A (ko) * 2007-06-19 2010-05-11 오츠카 가가쿠 가부시키가이샤 당사슬 부가 ｇｌｐ―１ 펩티드
US9234023B2 (en) * 2010-06-24 2016-01-12 Biousian Biosystems, Inc. Glucagon-like peptide-1 glycopeptides
DK2752424T3 (da) * 2011-09-04 2019-11-18 Glytech Inc Glycosyleret somatostatin og lægemiddelsammensætning, der indeholder det
CN102321170B (zh) * 2011-09-14 2013-11-13 深圳翰宇药业股份有限公司 利拉鲁肽变构体及其缀合物
DK2762489T3 (en) * 2011-10-01 2018-07-02 Glytech Inc GLYCOSYLED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
BR112015024423B1 (pt) * 2013-03-29 2023-04-25 Glytech, Inc Polipeptídeo glicosilado tendo atividade de interferon ?, composição farmacêutica e uso de um polipeptídeo glicosilado
PE20230304A1 (es) 2014-12-30 2023-02-13 Hanmi Pharm Ind Co Ltd Derivados de glucagon como agentes hipoglucemicos y antiobesidad
FI3322437T3 (fi) 2015-06-30 2024-02-20 Hanmi Pharmaceutical Co Ltd Glukagonijohdannainen ja sen pitkävaikutteisen konjugaatin käsittävä koostumus
TWI877582B (zh) 2015-12-31 2025-03-21 南韓商韓美藥品股份有限公司 三重升糖素／ｇｌｐ－１／ｇｉｐ受體促效劑
SG11201811697SA (en) 2016-06-29 2019-01-30 Hanmi Pharmaceutical Co Ltd Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
TW202140060A (zh) * 2020-01-13 2021-11-01 南韓商韓美藥品股份有限公司 對所有升糖素、ｇｌｐ－１及ｇｉｐ之受體均具有活性之三重促效劑之長效接合物之醫療用途
CN115463208B (zh) * 2021-10-09 2023-05-30 上海海赜生物科技有限公司 一种口服降糖组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005330A1 (ja) * 2002-07-05 2004-01-15 Otsuka Chemical Co., Ltd. 糖鎖アスパラギンを有する糖ペプチドの製造法及び該糖ペプチド
WO2005010053A1 (ja) * 2003-07-28 2005-02-03 Otsuka Chemical Co., Ltd. アミノ化複合型糖鎖誘導体及びその製造方法
WO2006010143A2 (en) * 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) * 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
HRP20050683A2 (en) 2003-03-19 2006-07-31 Eli Lilly And Company Polyethylene glycol linked glp-1 compounds
MXPA05013565A (es) * 2003-06-12 2006-03-09 Lilly Co Eli Proteinas de fusion analogas al glp-1.
JP2005095331A (ja) 2003-09-24 2005-04-14 Ihara Suisan Kk 魚皮真皮コラーゲンを含有する発泡体シートおよびその用途
EP1961764B1 (en) 2005-11-30 2011-05-11 Shionogi Co., Ltd. Sugar chain adduct of peptide and pharmaceutical comprising the same as active ingredient
KR20100049032A (ko) * 2007-06-19 2010-05-11 오츠카 가가쿠 가부시키가이샤 당사슬 부가 ｇｌｐ―１ 펩티드

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005330A1 (ja) * 2002-07-05 2004-01-15 Otsuka Chemical Co., Ltd. 糖鎖アスパラギンを有する糖ペプチドの製造法及び該糖ペプチド
WO2005010053A1 (ja) * 2003-07-28 2005-02-03 Otsuka Chemical Co., Ltd. アミノ化複合型糖鎖誘導体及びその製造方法
WO2006010143A2 (en) * 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MEURER J.A. ET AL.: "Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin (9-39)", METABOLISM, vol. 48, no. 6, 1999, pages 716 - 724, XP004538345 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765669B2 (en) 2008-06-17 2014-07-01 Glytech, Inc. Glycosylated GLP-1 peptide
WO2009153960A1 (ja) * 2008-06-17 2009-12-23 大塚化学株式会社 糖鎖付加ｇｌｐ－１ペプチド
AU2009261441B2 (en) * 2008-06-17 2013-01-10 Glytech, Inc. Oligosaccharide chain added glp-1 peptide
JP5604297B2 (ja) * 2008-06-17 2014-10-08 株式会社糖鎖工学研究所 糖鎖付加ｇｌｐ−１ペプチド
WO2011052523A1 (ja) * 2009-10-30 2011-05-05 大塚化学株式会社 抗原性ｇｌｐ－１アナログの糖鎖付加体
CN102666580A (zh) * 2009-10-30 2012-09-12 大塚化学株式会社 抗原性glp-1类似物的糖链加成物
JPWO2011052523A1 (ja) * 2009-10-30 2013-03-21 株式会社糖鎖工学研究所 抗原性ｇｌｐ−１アナログの糖鎖付加体
JPWO2012086812A1 (ja) * 2010-12-22 2014-06-05 味の素株式会社 配糖体化合物
WO2012130136A1 (zh) * 2011-03-29 2012-10-04 天津药物研究院 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
WO2014080730A1 (ja) * 2012-11-22 2014-05-30 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカー部分と生理活性物質部分とを含む化合物またはその塩、及びそれらの製造方法
JPWO2014080730A1 (ja) * 2012-11-22 2017-01-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカー部分と生理活性物質部分とを含む化合物またはその塩、及びそれらの製造方法
US9708413B2 (en) 2012-11-22 2017-07-18 Glytech, Inc. Glycosylated linker, compound containing glycosylated linker moiety and physiologically active substance moiety or salt thereof, and methods for producing said compound or salt thereof
WO2014084110A1 (ja) * 2012-11-30 2014-06-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
US10202469B2 (en) 2012-11-30 2019-02-12 Glytech, Inc. Sugar chain-attached linker, compound containing sugar chain-attached linker and physiologically active substance or salt thereof, and method for producing same
EP4015528A4 (en) * 2019-08-13 2023-09-20 Anygen Co., Ltd. EXENATIDE ANALOG AND ITS USE

Also Published As

Publication number Publication date
US8507429B2 (en) 2013-08-13
JP5646848B2 (ja) 2014-12-24
AU2008264750A1 (en) 2008-12-24
RU2539829C2 (ru) 2015-01-27
BRPI0813139A2 (pt) 2015-02-18
RU2010101331A (ru) 2011-07-27
DK2172479T3 (en) 2016-12-19
SG178797A1 (en) 2012-03-29
US20090111739A1 (en) 2009-04-30
TWI423821B (zh) 2014-01-21
AU2008264750B2 (en) 2012-07-05
US20110245166A1 (en) 2011-10-06
EP2172479A4 (en) 2011-08-24
EP2172479A1 (en) 2010-04-07
TW200902068A (en) 2009-01-16
US7985731B2 (en) 2011-07-26
AU2008264750C1 (en) 2013-01-10
CA2696615A1 (en) 2008-12-24
EP2172479B1 (en) 2016-09-14
JPWO2008155900A1 (ja) 2010-08-26
CN102015761A (zh) 2011-04-13
BRPI0813139A8 (pt) 2019-01-29
US20130345129A1 (en) 2013-12-26
KR20100049032A (ko) 2010-05-11

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