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WO2008153762A3 - Formulations s-nitrosothiol et systèmes d'entreposage - Google Patents

Formulations s-nitrosothiol et systèmes d'entreposage Download PDF

Info

Publication number
WO2008153762A3
WO2008153762A3 PCT/US2008/006640 US2008006640W WO2008153762A3 WO 2008153762 A3 WO2008153762 A3 WO 2008153762A3 US 2008006640 W US2008006640 W US 2008006640W WO 2008153762 A3 WO2008153762 A3 WO 2008153762A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitrosothiol
formulations
storage systems
nitrosoglutathione
provides stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/006640
Other languages
English (en)
Other versions
WO2008153762A2 (fr
Inventor
Douglas L Looker
Wayne F Beyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nivalis Therapeutics Inc
Original Assignee
N30 Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N30 Pharmaceuticals Inc filed Critical N30 Pharmaceuticals Inc
Publication of WO2008153762A2 publication Critical patent/WO2008153762A2/fr
Publication of WO2008153762A3 publication Critical patent/WO2008153762A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne un S-nitrosothiol stable, tel que le S-nitrosoglutathione, des formulations assurant un entreposage durable de S-nitrosothiols. Elle concerne également des formulations stables comprenant le S-nitrosothiol, telles que le S-nitrosoglutathione; et des méthodes de traitement de patients nécessitant le S-nitrosothiol, tel qu'un traitement à base de S-nitrosoglutathione et/ou d'acide nitrique.
PCT/US2008/006640 2007-05-25 2008-05-23 Formulations s-nitrosothiol et systèmes d'entreposage Ceased WO2008153762A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93173007P 2007-05-25 2007-05-25
US60/931,730 2007-05-25

Publications (2)

Publication Number Publication Date
WO2008153762A2 WO2008153762A2 (fr) 2008-12-18
WO2008153762A3 true WO2008153762A3 (fr) 2009-07-23

Family

ID=39869946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006640 Ceased WO2008153762A2 (fr) 2007-05-25 2008-05-23 Formulations s-nitrosothiol et systèmes d'entreposage

Country Status (1)

Country Link
WO (1) WO2008153762A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478767B2 (en) 2020-04-02 2025-11-25 The Regents Of The University Of Michigan Urinary catheter treatment

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065142A2 (fr) 2007-11-15 2009-05-22 Biomedical Research Foundation Of Northwest Louisiana Utilisation de sels de nitrite dans l'ischémie chronique
WO2010147742A2 (fr) 2009-06-18 2010-12-23 Theravasc Inc. Utilisation de sels de nitrates dans le traitement d'un endommagement tissulaire
AU2010306755B2 (en) 2009-10-14 2015-12-24 Theravasc Inc. Pharmaceutical formulations of nitrite and uses thereof
EP2874640A4 (fr) * 2012-01-05 2016-10-26 Frederick Timothy Guilford Glutathione réduite encapsulée dans un liposome pour le traitement du cancer, y compris en combinaison avec d'autres compositions pharmaceutiques
JP2016509030A (ja) 2013-02-20 2016-03-24 セラバスク インコーポレーテッド ニトライトの医薬製剤及びそれらの使用
GB201505347D0 (en) 2015-03-27 2015-05-13 Salupont Consulting Ltd Sterilisation of s-nitrosothiols
ITUB20154719A1 (it) 2015-10-21 2017-04-21 Glano Tech Ltd Formulazione per il rilascio di ossido nitrico
WO2017147295A1 (fr) * 2016-02-25 2017-08-31 The Regents Of The University Of Michigan Formulations générant de l'oxyde nitrique et kits
CN112004531B (zh) 2018-03-01 2023-11-24 密歇根大学董事会 两部分的生成一氧化氮的局部组合物
US10716805B2 (en) 2018-03-19 2020-07-21 Glanotech Limited Formulation for release of nitric oxide
MX2021015189A (es) 2019-06-10 2022-03-17 Univ Michigan Regents Dispositivos de inserción de catéteres.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900719A (en) * 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
WO1999030716A1 (fr) * 1997-12-16 1999-06-24 Alcon Laboratories, Inc. Utilisation de generateurs d'oxyde nitrique pour le traitement de syndromes de l'oeil sec
WO2007076053A2 (fr) * 2005-12-21 2007-07-05 Nitrox, Llc Formulations stables de s-nitrosothiol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900719A (en) * 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
WO1999030716A1 (fr) * 1997-12-16 1999-06-24 Alcon Laboratories, Inc. Utilisation de generateurs d'oxyde nitrique pour le traitement de syndromes de l'oeil sec
WO2007076053A2 (fr) * 2005-12-21 2007-07-05 Nitrox, Llc Formulations stables de s-nitrosothiol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARTHUR KREZEL ET AL: "Contrasting effects of metal ions on S-Nitrosoglutathione, Related to Coordination Equilibria: GSNO Decomposition Assisted by Ni(II) vs Stability Increase in the Presence of Zn(II) and Cd(II)", CHEM. RES. TOXICOL., vol. 17, 2004, pages 392 - 403, XP002530569 *
ZHENGUO LIU ET AL: "S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric oxide", THE J. OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 284, no. 2, 1998, pages 526 - 534, XP002530570 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478767B2 (en) 2020-04-02 2025-11-25 The Regents Of The University Of Michigan Urinary catheter treatment

Also Published As

Publication number Publication date
WO2008153762A2 (fr) 2008-12-18

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