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WO2008152669A3 - Colloidal vectors with polyaminoacid structure for oral release of peptides and proteins and method for their production - Google Patents

Colloidal vectors with polyaminoacid structure for oral release of peptides and proteins and method for their production Download PDF

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Publication number
WO2008152669A3
WO2008152669A3 PCT/IT2008/000376 IT2008000376W WO2008152669A3 WO 2008152669 A3 WO2008152669 A3 WO 2008152669A3 IT 2008000376 W IT2008000376 W IT 2008000376W WO 2008152669 A3 WO2008152669 A3 WO 2008152669A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
peptides
release
dosage forms
polyaminoacid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2008/000376
Other languages
French (fr)
Other versions
WO2008152669A2 (en
Inventor
Mariano Licciardi
Gaetano Giammona
Gennara Cavallaro
Giovanna Pitarresi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Palermo
Original Assignee
Universita degli Studi di Palermo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Palermo filed Critical Universita degli Studi di Palermo
Publication of WO2008152669A2 publication Critical patent/WO2008152669A2/en
Publication of WO2008152669A3 publication Critical patent/WO2008152669A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention concerns delivery systems for the release of active ingredients, specifically peptides and proteins, by means of their incorporation in nanoparticles, nano-aggregates or complexes based on suitably derivatized synthetic polyaminoacids, consisting of copolymers with a polyaspartamide backbone (specifically, alpha.beta-poly-hydroxyethyl-aspartamide or PHEA) to which hydrophobic functionalities, ioπisable functionalities and thiol functional- ities in side chains are covalently linked, each individually or in combination with each other. Such polymer systems are proposed to release peptide drugs or pro¬ teins, such as insulin, from oral dosage forms in an effective manner, and in order to increase the physicochemicai stability of proteins in liquid or solid pharmaceutical dosage forms.
PCT/IT2008/000376 2007-06-11 2008-06-04 Colloidal vectors with polyaminoacid structure for oral release of peptides and proteins and method for their production Ceased WO2008152669A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM20070327 ITRM20070327A1 (en) 2007-06-11 2007-06-11 COLLOIDAL VECTORS WITH POLYAMINOACIDIC STRUCTURE FOR THE ORAL RELEASE OF PEPTIDES AND PROTEINS AND ITS RELATED PRODUCTION METHOD.
ITRM2007A000327 2007-06-11

Publications (2)

Publication Number Publication Date
WO2008152669A2 WO2008152669A2 (en) 2008-12-18
WO2008152669A3 true WO2008152669A3 (en) 2009-02-12

Family

ID=39876522

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2008/000376 Ceased WO2008152669A2 (en) 2007-06-11 2008-06-04 Colloidal vectors with polyaminoacid structure for oral release of peptides and proteins and method for their production

Country Status (2)

Country Link
IT (1) ITRM20070327A1 (en)
WO (1) WO2008152669A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19810965A1 (en) * 1998-03-13 1999-09-16 Aventis Res & Tech Gmbh & Co Nanoparticles comprising polyelectrolyte complex of polycation, polyanion and biologically active agent, especially useful for controlled drug release on oral administration
US6342244B1 (en) * 1999-04-23 2002-01-29 Alza Corporation Releasable linkage and compositions containing same
WO2002098952A1 (en) * 2001-06-01 2002-12-12 Yamanouchi Europe B.V. Lipid-polymer-conjugates compositions
WO2003002096A1 (en) * 2001-06-28 2003-01-09 Wisconsin Alumni Research Foundation Methods and compositions for polyene antibiotics with reduced toxicity
WO2007034479A2 (en) * 2005-09-20 2007-03-29 Yissum Research Development Company Nanoparticles for targeted delivery of active agents
WO2007108031A2 (en) * 2006-03-17 2007-09-27 Sifi S.P.A. An ophthalmic pharmaceutical composition containing amphiphilic polyaspartamide copolymers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19810965A1 (en) * 1998-03-13 1999-09-16 Aventis Res & Tech Gmbh & Co Nanoparticles comprising polyelectrolyte complex of polycation, polyanion and biologically active agent, especially useful for controlled drug release on oral administration
US6342244B1 (en) * 1999-04-23 2002-01-29 Alza Corporation Releasable linkage and compositions containing same
WO2002098952A1 (en) * 2001-06-01 2002-12-12 Yamanouchi Europe B.V. Lipid-polymer-conjugates compositions
WO2003002096A1 (en) * 2001-06-28 2003-01-09 Wisconsin Alumni Research Foundation Methods and compositions for polyene antibiotics with reduced toxicity
WO2007034479A2 (en) * 2005-09-20 2007-03-29 Yissum Research Development Company Nanoparticles for targeted delivery of active agents
WO2007108031A2 (en) * 2006-03-17 2007-09-27 Sifi S.P.A. An ophthalmic pharmaceutical composition containing amphiphilic polyaspartamide copolymers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GIAMMONA G ET AL: "New biodegradable hydrogels based on a photocrosslinkable modified polyaspartamide: synthesis and characterization", BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1428, no. 1, 28 June 1999 (1999-06-28), pages 29 - 38, XP004276327, ISSN: 0304-4165 *
PITARRESI G ET AL: "Drug release from alpha,beta-poly(N-2-hydroxyethyl)-dl-aspartamide-b ased microparticles", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 25, no. 18, 1 August 2004 (2004-08-01), pages 4333 - 4343, XP004497095, ISSN: 0142-9612 *

Also Published As

Publication number Publication date
WO2008152669A2 (en) 2008-12-18
ITRM20070327A1 (en) 2008-12-12

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