[go: up one dir, main page]

WO2008151927A3 - Dérivés de benzimidazole à substitution 6-n pharmaceutiquement actifs - Google Patents

Dérivés de benzimidazole à substitution 6-n pharmaceutiquement actifs Download PDF

Info

Publication number
WO2008151927A3
WO2008151927A3 PCT/EP2008/056478 EP2008056478W WO2008151927A3 WO 2008151927 A3 WO2008151927 A3 WO 2008151927A3 EP 2008056478 W EP2008056478 W EP 2008056478W WO 2008151927 A3 WO2008151927 A3 WO 2008151927A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazole derivatives
acid pump
benz imidazole
pump antagonists
substituted benz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/056478
Other languages
English (en)
Other versions
WO2008151927A2 (fr
Inventor
Peter Jan Zimmermann
Christof Brehm
Andreas Palmer
Wilm Buhr
Joerg Senn-Bilfinger
Wolfgang-Alexander Simon
Michael Herrmann
Stefan Postius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Publication of WO2008151927A2 publication Critical patent/WO2008151927A2/fr
Publication of WO2008151927A3 publication Critical patent/WO2008151927A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (0), dans laquelle les substituants et les symboles sont tels que définis dans la description. Les composés inhibent la sécrétion de l'acide gastrique.
PCT/EP2008/056478 2007-06-15 2008-05-27 Dérivés de benzimidazole à substitution 6-n pharmaceutiquement actifs Ceased WO2008151927A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07110341.0 2007-06-15
EP07110341 2007-06-15
EP07111054.8 2007-06-26
EP07111054 2007-06-26

Publications (2)

Publication Number Publication Date
WO2008151927A2 WO2008151927A2 (fr) 2008-12-18
WO2008151927A3 true WO2008151927A3 (fr) 2009-04-09

Family

ID=40070887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/056478 Ceased WO2008151927A2 (fr) 2007-06-15 2008-05-27 Dérivés de benzimidazole à substitution 6-n pharmaceutiquement actifs

Country Status (1)

Country Link
WO (1) WO2008151927A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012000275A (es) 2009-07-09 2012-02-08 Raqualia Pharma Inc Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
WO2011029920A1 (fr) 2009-09-11 2011-03-17 Probiodrug Ag Dérivés hétérocycliques en tant qu'inhibiteurs de glutaminyle cyclase
HK1252562A1 (zh) * 2015-06-08 2019-05-31 Hk Inno.N Corporation 苯并咪唑衍生物用於夜间酸突破的用途
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
KR20170016754A (ko) * 2015-08-04 2017-02-14 씨제이헬스케어 주식회사 크로마논 유도체의 신규한 제조방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047603A1 (fr) * 1996-06-10 1997-12-18 Astra Aktiebolag Nouveaux composes
WO2004054984A1 (fr) * 2002-12-13 2004-07-01 Altana Pharma Ag Benzimidazoles substitues en position 4 et leur utilisation en tant qu'inhibiteurs de la secretion gastrique
WO2004087701A1 (fr) * 2003-04-04 2004-10-14 Altana Pharma Ag Benzimidazoles cycliques
WO2006134460A1 (fr) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Dérivés de benzimidazole à substitution chromane comme antagonistes de la pompe à acide
WO2006134111A1 (fr) * 2005-06-16 2006-12-21 Nycomed Gmbh Spiro-benzimidazoles utilises comme inhibiteurs de la secretion d'acide gastrique
WO2007003386A1 (fr) * 2005-06-30 2007-01-11 Glaxo Group Limited Dérivés d'imidazopyridine agissant comme antagoniste des pompes sécrétant l'acide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047603A1 (fr) * 1996-06-10 1997-12-18 Astra Aktiebolag Nouveaux composes
WO2004054984A1 (fr) * 2002-12-13 2004-07-01 Altana Pharma Ag Benzimidazoles substitues en position 4 et leur utilisation en tant qu'inhibiteurs de la secretion gastrique
WO2004087701A1 (fr) * 2003-04-04 2004-10-14 Altana Pharma Ag Benzimidazoles cycliques
WO2006134460A1 (fr) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Dérivés de benzimidazole à substitution chromane comme antagonistes de la pompe à acide
WO2006134111A1 (fr) * 2005-06-16 2006-12-21 Nycomed Gmbh Spiro-benzimidazoles utilises comme inhibiteurs de la secretion d'acide gastrique
WO2007003386A1 (fr) * 2005-06-30 2007-01-11 Glaxo Group Limited Dérivés d'imidazopyridine agissant comme antagoniste des pompes sécrétant l'acide

Also Published As

Publication number Publication date
WO2008151927A2 (fr) 2008-12-18

Similar Documents

Publication Publication Date Title
WO2008110355A8 (fr) Dérivés de quinoléine en tant que fongicides
WO2010063700A8 (fr) Nouveaux microbiocides
TN2010000101A1 (en) Fungicidal 2-alkylthio-2-quinolinyloxy -acetamide derivatives
WO2009024342A3 (fr) Nouveaux microbiocides
WO2009019015A8 (fr) Nouveaux herbicides
WO2009046841A8 (fr) Dérivés de pipéridine et de pipérazine
WO2009087098A3 (fr) Fongicides
WO2009156462A3 (fr) Composés organiques
TN2010000102A1 (en) Novel fungicides
WO2009043889A3 (fr) Dérivés d'oxadiazole
UA103625C2 (en) 5-hetrocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enons as herbicides
MX2010003156A (es) Derivados de aril amida substituida con tetrazol y usos de los mismos.
WO2008151828A8 (fr) Nouveaux microbiocides
MX2010001364A (es) Derivados de ciclopentandiona puenteados triciclicos como herbicidas.
MX2010003368A (es) Derivados de imidazol.
UA102289C2 (ru) Гербициды, полученные из циклопентадиона
WO2010071783A8 (fr) Thiazoles en tant que ligands des récepteurs des cannabinoïdes
UA101963C2 (en) 4-amino-pyrimidine derivatives
WO2009127718A3 (fr) Nouveaux microbiocides
WO2009003672A3 (fr) Nouveaux microbiocides
WO2008151927A3 (fr) Dérivés de benzimidazole à substitution 6-n pharmaceutiquement actifs
WO2009030450A8 (fr) Nouveaux herbicides
TW200600502A (en) Novel 6-substituted benzimidazoles
WO2009006267A3 (fr) N'-(2-halobenzylidene)sulfonylhydrazides en tant qu'intermédiaires dans la fabrication d'arylsulfonylindazoles
TW200720273A (en) Pharmaceutically active spiro-benzimidazoles

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08760076

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08760076

Country of ref document: EP

Kind code of ref document: A2