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WO2008146680A1 - Ｌ－リジンの製造法 - Google Patents

Ｌ－リジンの製造法 Download PDF

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Publication number
WO2008146680A1
WO2008146680A1 PCT/JP2008/059348 JP2008059348W WO2008146680A1 WO 2008146680 A1 WO2008146680 A1 WO 2008146680A1 JP 2008059348 W JP2008059348 W JP 2008059348W WO 2008146680 A1 WO2008146680 A1 WO 2008146680A1
Authority
WO
WIPO (PCT)
Prior art keywords
lysine
producing
culture medium
bacterial cells
ycdo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/059348
Other languages
English (en)
French (fr)
Inventor
Yousuke Nishio
Yohei Yamada
Yuri Nagai
Yoshihiro Usuda
Kazuhiko Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2008146680A1 publication Critical patent/WO2008146680A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ｌ－リジン生産能を有し、かつ、Ｎ－アセチル－アンヒドロムラミル－Ｌ－アラニン－アミダーゼ及びｅｆｅＯ(ｙｃｄＯ)遺伝子によりコードされるタンパク質の少なくともいずれかの活性が増大するように改変された腸内細菌科に属する細菌を培地で培養して、Ｌ－リジンを該培地中又は菌体内に生成蓄積させ、該培地又は菌体よりＬ－リジンを採取することにより、Ｌ－リジンを製造する。
PCT/JP2008/059348 2007-05-29 2008-05-21 Ｌ－リジンの製造法 Ceased WO2008146680A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-141905 2007-05-29
JP2007141905A JP2010187541A (ja) 2007-05-29 2007-05-29 Ｌ−リジンの製造法

Publications (1)

Publication Number Publication Date
WO2008146680A1 true WO2008146680A1 (ja) 2008-12-04

Family

ID=40316826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059348 Ceased WO2008146680A1 (ja) 2007-05-29 2008-05-21 Ｌ－リジンの製造法

Country Status (2)

Country Link
JP (1) JP2010187541A (ja)
WO (1) WO2008146680A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107937376A (zh) * 2017-10-19 2018-04-20 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN111154746A (zh) * 2020-01-13 2020-05-15 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5414636B2 (ja) 2010-08-24 2014-02-12 本田技研工業株式会社 車両用駆動装置
WO2016012607A1 (en) * 2014-07-25 2016-01-28 Delphi Genetics Improved host cell for producing proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117076A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117077A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117076A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117077A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IMAIZUMI A. ET AL.: "Improved Production of L-Lysine by Disruption of Stationary Phase-specific rmf Gene in Escherichia coli", J. BIOTECHNOL., vol. 117, no. 1, 2005, pages 111 - 118 *
JACOBS C. ET AL.: "AmpD, Essential for both Beta-lactamase Regulation and Cell Wall Recycling, is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase", MOL. MICROBIOL., vol. 15, no. 3, 1995, pages 553 - 559 *
STANCIK L.M. ET AL.: "pH-Dependent Expression of Periplasmic Proteins and Amino Acid Catabolism in Escherichia coli", J. BACTERIOL., vol. 184, no. 15, 2002, pages 4246 - 4258 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107937376A (zh) * 2017-10-19 2018-04-20 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN107937376B (zh) * 2017-10-19 2020-10-02 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN111154746A (zh) * 2020-01-13 2020-05-15 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用
CN111154746B (zh) * 2020-01-13 2021-10-08 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用

Also Published As

Publication number Publication date
JP2010187541A (ja) 2010-09-02

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