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WO2008141183A3 - Method and system for crystallization and x-ray diffraction screening - Google Patents

Method and system for crystallization and x-ray diffraction screening Download PDF

Info

Publication number
WO2008141183A3
WO2008141183A3 PCT/US2008/063247 US2008063247W WO2008141183A3 WO 2008141183 A3 WO2008141183 A3 WO 2008141183A3 US 2008063247 W US2008063247 W US 2008063247W WO 2008141183 A3 WO2008141183 A3 WO 2008141183A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystallization
ray diffraction
substrate layer
fluidic circuit
channels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/063247
Other languages
French (fr)
Other versions
WO2008141183A2 (en
Inventor
Brian Fowler
Andrew May
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Standard Biotools Inc
Original Assignee
Fluidigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Corp filed Critical Fluidigm Corp
Publication of WO2008141183A2 publication Critical patent/WO2008141183A2/en
Anticipated expiration legal-status Critical
Publication of WO2008141183A3 publication Critical patent/WO2008141183A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/20008—Constructional details of analysers, e.g. characterised by X-ray source, detector or optical system; Accessories therefor; Preparing specimens therefor
    • G01N23/20025—Sample holders or supports therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
PCT/US2008/063247 2007-05-09 2008-05-09 Method and system for crystallization and x-ray diffraction screening Ceased WO2008141183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92864907P 2007-05-09 2007-05-09
US60/928,649 2007-05-09
US92886507P 2007-05-11 2007-05-11
US60/928,865 2007-05-11

Publications (2)

Publication Number Publication Date
WO2008141183A2 WO2008141183A2 (en) 2008-11-20
WO2008141183A3 true WO2008141183A3 (en) 2009-12-30

Family

ID=40002868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/063247 Ceased WO2008141183A2 (en) 2007-05-09 2008-05-09 Method and system for crystallization and x-ray diffraction screening

Country Status (2)

Country Link
US (2) US7974380B2 (en)
WO (1) WO2008141183A2 (en)

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US7294503B2 (en) 2000-09-15 2007-11-13 California Institute Of Technology Microfabricated crossflow devices and methods
EP1343973B2 (en) 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
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EP1551753A2 (en) 2002-09-25 2005-07-13 California Institute Of Technology Microfluidic large scale integration
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
EP1546412B1 (en) * 2002-10-02 2014-05-21 California Institute Of Technology Microfluidic nucleic acid analysis
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7695683B2 (en) 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
CN103884698B (en) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
EP1838431A4 (en) * 2004-12-03 2012-08-22 California Inst Of Techn MICROFLUIDIC DEVICES WITH CIRCUITS FOR CHEMICAL REACTIONS
WO2006060748A2 (en) 2004-12-03 2006-06-08 California Institute Of Technology Microfluidic sieve valves
EP1882189A2 (en) 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US8473216B2 (en) * 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US8157434B2 (en) * 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
BRPI0816393A2 (en) 2007-09-07 2015-03-03 Fluidigm Corp METHOD FOR DETERMINING THE NUMBER OF COPIES REGARDING A TARGET POLINUCLEOTIDE SEQUENCE IN A GENOME OF AN INDIVIDUAL
WO2009100449A1 (en) 2008-02-08 2009-08-13 Fluidigm Corporation Dynamic array assay methods
EP2280905B1 (en) 2008-04-11 2016-07-06 Fluidigm Corporation Multilevel microfluidic systems and methods
CN102165076B (en) 2008-07-25 2014-07-09 弗卢丁公司 Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8551787B2 (en) * 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
EP2506882A4 (en) 2009-11-30 2017-05-17 Fluidigm Corporation Microfluidic device regeneration
US20120044341A1 (en) * 2010-08-19 2012-02-23 Stith Curtis W Optofluidic microscope system-on-chip
WO2012054933A2 (en) 2010-10-22 2012-04-26 Fluidigm Corporation Universal probe assay methods
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
US9469871B2 (en) 2011-04-14 2016-10-18 Corporos Inc. Methods and apparatus for point-of-care nucleic acid amplification and detection
CN103635594B (en) 2011-05-09 2018-02-13 富鲁达公司 Probe-based nucleic acid detection
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
US9354159B2 (en) 2012-05-02 2016-05-31 Nanoscopia (Cayman), Inc. Opto-fluidic system with coated fluid channels
DK2936164T3 (en) * 2012-12-18 2020-04-06 European Molecular Biology Laboratory Embl AUTOMATION OF INCUBATION, TREATMENT, HARVESTING AND ANALYSIS OF SAMPLES IN A MULTICELLE PLATE WITH A THINFILM SUPPORT FOR THE SAMPLE
US9347962B2 (en) * 2013-08-05 2016-05-24 Nanoscopia (Cayman), Inc. Handheld diagnostic system with chip-scale microscope and automated image capture mechanism
US9869648B2 (en) * 2014-06-26 2018-01-16 The Board Of Trustees Of The Leland Stanford Junior University High density grids
US10365188B2 (en) 2014-08-22 2019-07-30 Brandeis University Microfluidic devices for investigating crystallization
WO2016044545A1 (en) 2014-09-17 2016-03-24 Alexandra Ros Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
JP6925050B2 (en) 2017-03-01 2021-08-25 国立大学法人 東京大学 Method of identifying molecular structure
WO2018217831A1 (en) 2017-05-22 2018-11-29 Arizona Board Of Regents On Behalf Of Arizona State University Metal electrode based 3d printed device for tuning microfluidic droplet generation frequency and synchronizing phase for serial femtosecond crystallography
WO2018217793A1 (en) 2017-05-22 2018-11-29 Arizona Board Of Regents On Behalf Of Arizona State University 3d printed microfluidic mixers and nozzles for crystallography
US11173487B2 (en) 2017-12-19 2021-11-16 Arizona Board Of Regents On Behalf Of Arizona State University Deterministic ratchet for sub-micrometer bioparticle separation
JP6742624B2 (en) * 2017-12-27 2020-08-19 大連理工大学 Experimental system and method applied to precise adjustment and control of large molecule crystallization process
US11624718B2 (en) 2019-05-14 2023-04-11 Arizona Board Of Regents On Behalf Of Arizona State University Single piece droplet generation and injection device for serial crystallography
US11318487B2 (en) 2019-05-14 2022-05-03 Arizona Board Of Regents On Behalf Of Arizona State University Co-flow injection for serial crystallography
US11746642B2 (en) * 2019-11-08 2023-09-05 Halliburton Energy Services, Inc. Electromagnetic imager design
US11549894B2 (en) * 2020-04-06 2023-01-10 Saudi Arabian Oil Company Determination of depositional environments
US11485632B2 (en) 2020-10-09 2022-11-01 Arizona Board Of Regents On Behalf Of Arizona State University Modular 3-D printed devices for sample delivery and method
WO2022165422A1 (en) * 2021-02-01 2022-08-04 The Regents Of The University Of California 2d polymer based targets for serial x-ray crystallography

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US20030061687A1 (en) * 2000-06-27 2003-04-03 California Institute Of Technology, A California Corporation High throughput screening of crystallization materials
US20050062196A1 (en) * 2001-04-06 2005-03-24 California Institute Of Technology Microfluidic protein crystallography techniques
US20060246493A1 (en) * 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples

Also Published As

Publication number Publication date
US7974380B2 (en) 2011-07-05
WO2008141183A2 (en) 2008-11-20
US8422632B2 (en) 2013-04-16
US20090147918A1 (en) 2009-06-11
US20120021523A1 (en) 2012-01-26

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