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WO2008038122A3 - Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives - Google Patents

Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives Download PDF

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Publication number
WO2008038122A3
WO2008038122A3 PCT/IB2007/002846 IB2007002846W WO2008038122A3 WO 2008038122 A3 WO2008038122 A3 WO 2008038122A3 IB 2007002846 W IB2007002846 W IB 2007002846W WO 2008038122 A3 WO2008038122 A3 WO 2008038122A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimethyl
amino
carboxylic acid
preparation
piperidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/002846
Other languages
French (fr)
Other versions
WO2008038122A2 (en
Inventor
Prasad Keshav Deshpande
Satish Baliram Bhavsar
Sanjeev Narhari Joshi
Rajesh Prabhakar Kale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Research Centre
Original Assignee
Wockhardt Research Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Centre filed Critical Wockhardt Research Centre
Publication of WO2008038122A2 publication Critical patent/WO2008038122A2/en
Anticipated expiration legal-status Critical
Publication of WO2008038122A3 publication Critical patent/WO2008038122A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to process for the preparation of racemic and optically pure enantiomers of 1-cyclopropyl-6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1-yl)-4- oxo-l,4-dihydro-quinolin-3-carboxylic acid and salts thereof. The present invention also provides novel crystalline forms of racemic and optically pure enantiomers of 1-cyclopropyl- 6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1 -yl)-4-oxo-1,4-dihydro-quinolin-3- carboxylic acid hydrochloride and compositions containing polymorphs. The present invention further provides pure (RS)-(±)-4-amino-3,3-dimethyl-piperidine and pure (R) or (S)-enantiomers of 4-amino-3,3-dimethyl-piperidine compounds.
PCT/IB2007/002846 2006-09-29 2007-09-28 Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives Ceased WO2008038122A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1628MU2006 2006-09-29
IN1628/MUM/2006 2006-09-29

Publications (2)

Publication Number Publication Date
WO2008038122A2 WO2008038122A2 (en) 2008-04-03
WO2008038122A3 true WO2008038122A3 (en) 2009-04-23

Family

ID=39230590

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002846 Ceased WO2008038122A2 (en) 2006-09-29 2007-09-28 Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives

Country Status (1)

Country Link
WO (1) WO2008038122A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
WO2002085886A2 (en) * 2001-04-25 2002-10-31 Wockhardt Limited Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
WO2002085886A2 (en) * 2001-04-25 2002-10-31 Wockhardt Limited Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions

Also Published As

Publication number Publication date
WO2008038122A2 (en) 2008-04-03

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