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WO2008036967A3 - Novel heterocyclic compounds as lasy activators - Google Patents

Novel heterocyclic compounds as lasy activators Download PDF

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Publication number
WO2008036967A3
WO2008036967A3 PCT/US2007/079286 US2007079286W WO2008036967A3 WO 2008036967 A3 WO2008036967 A3 WO 2008036967A3 US 2007079286 W US2007079286 W US 2007079286W WO 2008036967 A3 WO2008036967 A3 WO 2008036967A3
Authority
WO
WIPO (PCT)
Prior art keywords
lasy
activators
heterocyclic compounds
novel heterocyclic
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/079286
Other languages
French (fr)
Other versions
WO2008036967A2 (en
Inventor
Dumbala Srinivas Reddy
Indira Padmalayam
Debnath Bhuniya
Sivaram Pillarisetti
Ranjan Chakrabarti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reddy US Therapeutics Inc
Original Assignee
Reddy US Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddy US Therapeutics Inc filed Critical Reddy US Therapeutics Inc
Publication of WO2008036967A2 publication Critical patent/WO2008036967A2/en
Publication of WO2008036967A3 publication Critical patent/WO2008036967A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer
PCT/US2007/079286 2006-09-22 2007-09-24 Novel heterocyclic compounds as lasy activators Ceased WO2008036967A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84649906P 2006-09-22 2006-09-22
US60/846,499 2006-09-22

Publications (2)

Publication Number Publication Date
WO2008036967A2 WO2008036967A2 (en) 2008-03-27
WO2008036967A3 true WO2008036967A3 (en) 2008-09-18

Family

ID=39201359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079286 Ceased WO2008036967A2 (en) 2006-09-22 2007-09-24 Novel heterocyclic compounds as lasy activators

Country Status (1)

Country Link
WO (1) WO2008036967A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001632A1 (en) * 2007-06-05 2009-10-16 Sanofi Aventis Compounds derived from substituted benzoylamino-indan-2-carboxylic acids, inhibitors of the cxcr5 receptor; pharmaceutical composition; and its use in the treatment of inflammatory physiological effects, such as rheumatoid arthritis and asthma.
BR112013017316A2 (en) 2011-01-04 2019-09-24 Novartis Ag indole compounds or analogues thereof for the treatment of age-related macular degeneration (amd)
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2867225B1 (en) 2012-06-28 2017-08-09 Novartis AG Pyrrolidine derivatives and their use as complement pathway modulators
US9464081B2 (en) 2012-06-28 2016-10-11 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
JP6214647B2 (en) 2012-06-28 2017-10-18 ノバルティス アーゲー Complement pathway modulators and uses thereof
WO2014002051A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
US9388199B2 (en) 2012-06-28 2016-07-12 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
WO2014009833A2 (en) 2012-07-12 2014-01-16 Novartis Ag Complement pathway modulators and uses thereof
RS60878B1 (en) * 2014-04-04 2020-11-30 Iomet Pharma Ltd Indole derivatives for use in medicine
US20190016680A1 (en) 2016-01-14 2019-01-17 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
GB201704476D0 (en) 2017-03-21 2017-05-03 Antabio Sas Chemical compounds
JP7429993B2 (en) 2018-09-25 2024-02-09 アンタビオ エスアーエス Indane derivatives for use in the treatment of bacterial infections
JP2023512821A (en) 2020-02-04 2023-03-29 マインドセット ファーマ インコーポレイテッド 3-pyrrolidine indole derivatives as serotonergic hallucinogens for the treatment of central nervous system disorders
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196111B2 (en) * 2002-06-04 2007-03-27 Schering Corporation Pyrazolo[1,5a]pyrimidine compounds as antiviral agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196111B2 (en) * 2002-06-04 2007-03-27 Schering Corporation Pyrazolo[1,5a]pyrimidine compounds as antiviral agents

Also Published As

Publication number Publication date
WO2008036967A2 (en) 2008-03-27

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