[go: up one dir, main page]

WO2008036067A3 - Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents - Google Patents

Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents Download PDF

Info

Publication number
WO2008036067A3
WO2008036067A3 PCT/US2006/027763 US2006027763W WO2008036067A3 WO 2008036067 A3 WO2008036067 A3 WO 2008036067A3 US 2006027763 W US2006027763 W US 2006027763W WO 2008036067 A3 WO2008036067 A3 WO 2008036067A3
Authority
WO
WIPO (PCT)
Prior art keywords
amides
carboxylic acid
thiazolidinone
cancer agents
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/027763
Other languages
French (fr)
Other versions
WO2008036067A2 (en
Inventor
Duane D Miller
Veeresa Gududuru
James T Dalton
Eunju Hurh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Ohio State University Research Foundation
Original Assignee
University of Tennessee Research Foundation
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation, Ohio State University Research Foundation filed Critical University of Tennessee Research Foundation
Priority to EP06851619A priority Critical patent/EP1926487A2/en
Anticipated expiration legal-status Critical
Publication of WO2008036067A2 publication Critical patent/WO2008036067A2/en
Publication of WO2008036067A3 publication Critical patent/WO2008036067A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
PCT/US2006/027763 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents Ceased WO2008036067A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06851619A EP1926487A2 (en) 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70065305P 2005-07-19 2005-07-19
US60/700,653 2005-07-19

Publications (2)

Publication Number Publication Date
WO2008036067A2 WO2008036067A2 (en) 2008-03-27
WO2008036067A3 true WO2008036067A3 (en) 2009-02-12

Family

ID=39201002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027763 Ceased WO2008036067A2 (en) 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents

Country Status (2)

Country Link
EP (1) EP1926487A2 (en)
WO (1) WO2008036067A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
PL2303021T3 (en) 2008-06-16 2019-10-31 Univ Tennessee Res Found Compounds for the treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
RU2581367C2 (en) 2010-03-01 2016-04-20 Джи Ти Икс, ИНК. Compounds for treating cancer
CA2868857C (en) 2012-03-26 2020-06-02 Board Of Regents, The University Of Texas System Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225102A1 (en) * 2002-04-08 2003-12-04 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
WO2005049591A1 (en) * 2003-11-18 2005-06-02 University Of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225102A1 (en) * 2002-04-08 2003-12-04 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
WO2005049591A1 (en) * 2003-11-18 2005-06-02 University Of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Also Published As

Publication number Publication date
EP1926487A2 (en) 2008-06-04
WO2008036067A2 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
WO2006032342A3 (en) Carbonyl compound-containing drug and the use thereof
WO2009046842A3 (en) Thiazol derivatives for treating cancer
EP1951729A4 (en) OXYGEN-BOUND PYRIMIDINE DERIVATIVES
SE0401971D0 (en) Piperidne derivatives
WO2009046841A8 (en) Piperidine and piperazine derivatives for treating tumours
WO2007081974A3 (en) Viral hepatitis treatment
WO2006086562A3 (en) Phenylazetidinone derivatives
WO2005004818A3 (en) Heterocyclic compounds and their use as anticancer agents
WO2005110994A3 (en) Substituted pyrazolyl urea derivatives useful in the treatment of cancer
WO2004075864A3 (en) Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
IL196543A (en) Pyridazinone derivatives and pharmaceutical compositions comprising them for use in the treatment of disorders
WO2007044084A3 (en) Heterocyclic inhibitors of mek and methods of use thereof
WO2008101682A3 (en) Iminipyridine derivatives and their uses as microbiocides
WO2007109279A3 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
DE60003863D1 (en) Dioxocyclopentylhydroxamsäure
TW200738241A (en) Pyridazine derivatives
EA200700096A1 (en) DERIVATIVES 2-CARBAMID-4-PHENYL THIAZOLE, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION IN THERAPY
WO2006028525A3 (en) [3.2.0] heterocyclic compounds and methods of using the same
DE602004024213D1 (en) Aminopropanolderivate
MY147262A (en) 1-aza-bicyclo[3.3.1]nonanes
WO2007046868A3 (en) Thiazolidine derivatives and their uses as therapeutic agents
WO2006100082A3 (en) Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
WO2006000371A3 (en) Pyrimidine derivatives as 11beta-hsd1 inhibitors
WO2008104473A3 (en) Pyrazolopyriidine derivatives and their use as kinase inhibitors
TW200740764A (en) Pyrazolone derivatives

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006851619

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06851619

Country of ref document: EP

Kind code of ref document: A2