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WO2008032314A3 - Systems, devices and methods for freezing and thawing biological materials - Google Patents

Systems, devices and methods for freezing and thawing biological materials Download PDF

Info

Publication number
WO2008032314A3
WO2008032314A3 PCT/IL2007/001120 IL2007001120W WO2008032314A3 WO 2008032314 A3 WO2008032314 A3 WO 2008032314A3 IL 2007001120 W IL2007001120 W IL 2007001120W WO 2008032314 A3 WO2008032314 A3 WO 2008032314A3
Authority
WO
WIPO (PCT)
Prior art keywords
bag
heat source
tank
heat
biological material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2007/001120
Other languages
French (fr)
Other versions
WO2008032314A2 (en
Inventor
Ginadi Shaham
Yehudit Natan
Dana Lorber
Peter Bartal
Yoram Amsalem
Yaniv Damari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interface Multigrad Technology Ltd
Original Assignee
Interface Multigrad Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interface Multigrad Technology Ltd filed Critical Interface Multigrad Technology Ltd
Priority to US12/440,846 priority Critical patent/US20100281886A1/en
Priority to EP07805579A priority patent/EP2063706A2/en
Publication of WO2008032314A2 publication Critical patent/WO2008032314A2/en
Anticipated expiration legal-status Critical
Publication of WO2008032314A3 publication Critical patent/WO2008032314A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
    • A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/147—Carriers for immersion in cryogenic fluid for slow freezing or vitrification

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

There are provided a system and a method for cryopreserving a liquid biological material disposed in a bag having a longitudinal axis. The system comprises a bag holder for holding the bag, so that the biological material therein has a surface area S, and a volume V, a tank containing a cryogenic fluid, a mechanism for the immersion of the bag holder into the tank along the longitudinal axis, an opening in the tank for insertion therethrough of the bag holder, and a guide member extending from the opening into the tank. There are further provided a system and a method for warming a cryopreserved liquid biological material disposed in a bag. The system comprises a heat source, a warming device having a space for placing the bag therein, connected to the heat source and adapted to transfer heat from the heat source to the bag, and means for maintaining the heat source in heat transfer contact with a cryogenically preserved portion of the material to allow receiving the heat by said cryogenically preserved portion.
PCT/IL2007/001120 2006-09-11 2007-09-11 Systems, devices and methods for freezing and thawing biological materials Ceased WO2008032314A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/440,846 US20100281886A1 (en) 2006-09-11 2007-09-11 Systems, devices and methods for freezing and thawing biological materials
EP07805579A EP2063706A2 (en) 2006-09-11 2007-09-11 Systems, devices and methods for freezing and thawing biological materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84339406P 2006-09-11 2006-09-11
US60/843,394 2006-09-11

Publications (2)

Publication Number Publication Date
WO2008032314A2 WO2008032314A2 (en) 2008-03-20
WO2008032314A3 true WO2008032314A3 (en) 2009-07-16

Family

ID=39040314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/001120 Ceased WO2008032314A2 (en) 2006-09-11 2007-09-11 Systems, devices and methods for freezing and thawing biological materials

Country Status (3)

Country Link
US (1) US20100281886A1 (en)
EP (1) EP2063706A2 (en)
WO (1) WO2008032314A2 (en)

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US8449938B2 (en) 2002-05-14 2013-05-28 Valio Ltd Lactose-free milk product and processes for producing the same
FI115752B (en) 2002-05-14 2005-07-15 Valio Oy Process to be used in the preparation of a lactose-low or lactose-free milk product
WO2005073652A2 (en) 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Apparatus, system and method for lyophilization
EP1711053A2 (en) 2004-02-02 2006-10-18 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
US7892726B2 (en) 2004-06-07 2011-02-22 Core Dynamics Limited Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation
EP1778007A1 (en) 2004-08-12 2007-05-02 I.M.T. Interface Multigrad Technology Ltd. Method and apparatus for freezing or thawing of a biological material
EP1909565A2 (en) 2005-08-03 2008-04-16 Interface Multigrad Technology (IMT) Ltd. Somatic cells for use in cell therapy
DE102008048709B4 (en) 2008-09-24 2018-05-17 Ingenieurbüro und Plastverarbeitung Quinger GmbH Method and device for tempering tissue parts
US9700038B2 (en) 2009-02-25 2017-07-11 Genea Limited Cryopreservation of biological cells and tissues
ES2948493T3 (en) 2010-05-28 2023-09-13 Genea Ip Holdings Pty Ltd Improved micromanipulation and storage devices and methods
US20120210734A1 (en) * 2011-02-22 2012-08-23 Hoffman Gary A Production and use of high pressure for cryopreservation and cryofixation
EP2601869A1 (en) * 2011-12-09 2013-06-12 Koninklijke Philips Electronics N.V. Baby bottle warmer
WO2013090943A1 (en) * 2011-12-16 2013-06-20 Northeastern University Methods and systems for minimization of mechanical effects of impact velocity during tissue preservation
HK1201911A1 (en) * 2012-02-21 2015-09-11 Celularity, Inc. Devices and methods for thawing biological material
US20130333404A1 (en) * 2012-06-19 2013-12-19 Darryl H. Yong Safe and compact machine for rapidly producing frozen confections
US9441893B2 (en) * 2012-07-25 2016-09-13 Grifols, S.A. Thawing vessel for biological products
US9936690B2 (en) 2014-03-28 2018-04-10 Board Of Trustees Of Northern Illinois University Ultra-rapid tissue cryopreservation method and apparatus
US10196598B2 (en) 2014-10-07 2019-02-05 Cpsi Holdings Llc System for heating and cooling samples
GB201421556D0 (en) 2014-12-04 2015-01-21 Milne S And Lamb S Improved method and equipment for thawing cryopreserved samples
WO2016200980A1 (en) * 2015-06-08 2016-12-15 The Regents Of The University Of Colorado A Body Corporate Apparatus and methods for freezing, storing, and thawing biological materials
GB201604062D0 (en) * 2016-03-09 2016-04-20 Cell Therapy Catapult Ltd A device for heating or cooling a sample
US20190191693A1 (en) * 2016-08-24 2019-06-27 Merck Sharp & Dohme Corp. Container System and Method for Freezing and Thawing a Liquid Product
WO2018195107A1 (en) * 2017-04-17 2018-10-25 MedCision, Inc. Systems, devices, and methods for automated large gauge sample thawing
US11352262B2 (en) 2017-12-18 2022-06-07 Praxair Technology, Inc. Methods for automatic filling, charging and dispensing carbon dioxide snow block
BR112020024208A2 (en) * 2018-05-31 2021-02-17 Vitalant methods and systems for cryopreservation and resuspension of body fluids
US20200129309A1 (en) * 2018-10-30 2020-04-30 Surgentec, Llc Method and container for delivering bone graft material
EP3924675B1 (en) 2019-02-17 2023-07-05 National Scientific And Technical Research Council - Argentina (Conicet) System for accessing biological samples in a cryogenic dewar vessel
JP7133514B2 (en) * 2019-06-12 2022-09-08 三菱製紙株式会社 Cell or tissue freeze-thaw method
CA3155035C (en) 2019-10-29 2024-06-04 William Alan BLAIR Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
EP4154257A4 (en) 2020-05-18 2023-12-06 TMRW Life Sciences, Inc. HANDLING AND MONITORING BIOLOGICAL SAMPLES FOR CRYOGENIC STORAGE
CA3155039A1 (en) 2020-09-24 2022-03-31 Amit Gupta Cryogenic storage system with sensors to measure one or more parameters therewithin
US12285009B2 (en) 2020-09-24 2025-04-29 TMRW Life Sciences, Inc. Workstation and apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
AU2021351505B2 (en) 2020-10-02 2024-11-21 TMRW Life Sciences, Inc. Interrogation device and/or system having alignment feature(s) for wireless transponder tagged specimen containers and/or carriers
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
WO2022125817A1 (en) 2020-12-10 2022-06-16 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to secimen collection body
US12259399B2 (en) 2021-01-13 2025-03-25 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers
CN113069613A (en) * 2021-03-22 2021-07-06 广州市天河诺亚生物工程有限公司 Navel cord blood rewarming leak protection box
WO2023060222A1 (en) 2021-10-08 2023-04-13 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers
WO2025111515A1 (en) * 2023-11-22 2025-05-30 Mitegen, Llc Systems, methods, and devices for cryopreservation and recovery of cells and other biological materials

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GB1468371A (en) * 1973-03-02 1977-03-23 Union Carbide Corp Apparatus for holding
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US4107937A (en) * 1975-12-22 1978-08-22 Linde Aktiengesellschaft Method of and apparatus for the deep freezing of biological substances
US4251995A (en) * 1979-04-25 1981-02-24 Hedbergska Stiftelsen Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate device
US20040134203A1 (en) * 2001-05-22 2004-07-15 Integrated Biosystems, Inc. Systems and methods for freezing, storing and thawing biopharmaceutical material

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US6631616B2 (en) * 2001-05-22 2003-10-14 Richard Wisniewski Cryopreservation system with controlled dendritic freezing front velocity
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GB1409272A (en) * 1971-08-30 1975-10-08 Union Carbide Corp Method and apparatus for cryogenic freezing of fluid filled pouches
GB1468371A (en) * 1973-03-02 1977-03-23 Union Carbide Corp Apparatus for holding
US4018911A (en) * 1975-11-10 1977-04-19 The United States Of America As Represented By The Secretary Of The Navy Method for large volume freezing and thawing of packed erythrocytes
US4107937A (en) * 1975-12-22 1978-08-22 Linde Aktiengesellschaft Method of and apparatus for the deep freezing of biological substances
US4251995A (en) * 1979-04-25 1981-02-24 Hedbergska Stiftelsen Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate device
US20040134203A1 (en) * 2001-05-22 2004-07-15 Integrated Biosystems, Inc. Systems and methods for freezing, storing and thawing biopharmaceutical material

Also Published As

Publication number Publication date
EP2063706A2 (en) 2009-06-03
WO2008032314A2 (en) 2008-03-20
US20100281886A1 (en) 2010-11-11

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