[go: up one dir, main page]

WO2008031853A1 - Pointe de diffuseur pour répartition homogène du rayonnement de rayons x faiblement énergétique dans un milieu - Google Patents

Pointe de diffuseur pour répartition homogène du rayonnement de rayons x faiblement énergétique dans un milieu Download PDF

Info

Publication number
WO2008031853A1
WO2008031853A1 PCT/EP2007/059595 EP2007059595W WO2008031853A1 WO 2008031853 A1 WO2008031853 A1 WO 2008031853A1 EP 2007059595 W EP2007059595 W EP 2007059595W WO 2008031853 A1 WO2008031853 A1 WO 2008031853A1
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
ray
scattering
target volume
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/059595
Other languages
German (de)
English (en)
Inventor
Hansjörg ALBRECHT
Hans-Joachim Cappius
Tilmann HÄUPL
Michael Haschke
Frank Wacker
Jürgen BEUTHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laser und Medizin Technologie GmbH
Original Assignee
Laser und Medizin Technologie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laser und Medizin Technologie GmbH filed Critical Laser und Medizin Technologie GmbH
Priority to DE112007002080T priority Critical patent/DE112007002080A5/de
Publication of WO2008031853A1 publication Critical patent/WO2008031853A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/16—Vessels
    • H01J2235/163—Vessels shaped for a particular application
    • H01J2235/164—Small cross-section, e.g. for entering in a body cavity

Definitions

  • Diffuser tip for homogeneous radiation distribution of low-energy X-radiation in a medium
  • the invention relates to a device for the most uniform possible irradiation of the environment of an applicator introduced into a body with X-radiation.
  • the invention relates to a method for the most uniform possible irradiation of the environment of an applicator introduced into a body with X-radiation.
  • the irradiation of malignant changes in the body is an established method for the treatment of space-occupying processes.
  • the radiation beyond the biocompatibility of the target volume is carried out by introducing encapsulated radionuclides into the target volume or by means of radiation sources from outside the body.
  • An advantage of introducing encapsulated radionuclides is the homogenous radiation delivery around the capsule, whereby the healthy tissue lying outside the target volume can be spared with appropriate arrangement.
  • Disadvantageous in the introduction of radionuclides is the required shielding of the radiation in advance of the introduction and during transport, since the radionuclides are continuously active in radiation. Also, depending on local legislation, special permits are required to take precautionary measures and to ensure special waste disposal.
  • the decay of the radionuclide which indeed generates the effective radiation, is time-dependent and thus makes the dosimetry of the applied radiation quantity in the volume more difficult. Dosimetry ensures that radiation is above the biologically tolerated level only within the predefined target volume and that the surrounding healthy tissue is not irreparably damaged.
  • Radiation sources outside the body such as linear accelerators or X-ray sources have the advantage that radiation is emitted only when it is switched on, but the great disadvantage of damaging healthy tissue lying between the radiation source and target volume until the radiation reaches the target volume and damages it as intended. This limits the number of irradiations due to the tolerance of the irradiated, healthy tissue.
  • the solution according to the invention is intended to distribute low-energy X-ray radiation as homogeneously as possible in a target volume.
  • WO 2005/120201 describes a possibility of deflecting the radiation at the distal end of a tubular device which essentially produces a beam lobe which is out of alignment with the tubular device - A -
  • the uncertainty in the irradiation is that close to the device in discrete directions perpendicular to the beam directed onto the device, a high intensity, but distant from the device and at the edges of the beam beam, an expiring damage zone, which is highly dependent on the externally applied radiation amount and energy has.
  • the secure detection of a target volume can therefore only be done by multiple applications from different sides of the target volume.
  • a device is preferably provided in the form of a scattering body or diffuser which transmits or defines an X-ray scattering substance or a substance mixture in the form of small X-ray deflecting particles (scattering particles) in a X-ray transmissive X-ray weakening matrix comprises or contains, wherein the substance or the substance mixture is preferably evenly distributed, so that a rotationally symmetric radiation distribution about the axis of this scattering body (diffuser) directed X-radiation takes place.
  • a continuation of the inventive idea is the use of X-ray-fluorescent particles instead of or mixed with the above-mentioned scattering particles.
  • the use of X-ray radiation which is strongly absorbed in the scattering body is also made possible by the introduction of the body into the body through, for example, a tubular device and the subsequent scattering in the scattering body far from the surface, without taking into account other boundary conditions such as heat generation or radiation outside Target volume of lying body elements have to take.
  • the parameters of the x-ray source, in an x-ray tube for example, acceleration voltage, tube current, anode material, filters and collimators, it is possible to adapt the radiation to the size of the target volume. Since the scattering body thus itself forms a radiation source which can be brought directly to the target volume and is not removed from the target volume, there is no damage to surrounding tissue.
  • An accurate dose distribution is precisely predictable and, when using low-energy X-ray radiation on the human and animal body, has a steep dose edge drop compared to other established types of radiation.
  • the method can be used without any effect restriction in the vicinity of radiation-sensitive structures.
  • the application is thereby simplified compared to other radiosurgical methods and the dose planning and the therapy control can be carried out with the conventional imaging methods according to the prior art (ultrasound, magnetic resonance tomography, computed tomography, etc.).
  • the application is not explicitly limited to the radiosurgical application, but open z. Also for illumination purposes (for example X-ray film exposure, X-ray radiation via fluorescence into optical radiation) or other desired interaction mechanisms of ionizing radiation, even outside the application to the human or animal body.
  • illumination purposes for example X-ray film exposure, X-ray radiation via fluorescence into optical radiation
  • other desired interaction mechanisms of ionizing radiation even outside the application to the human or animal body.
  • the X-ray radiation from external sources can be conducted into the body virtually loss-free by means of a percutaneously placed X-ray waveguide.
  • X-ray light guides are capillary structures in which the X-ray radiation is passed on by multiple total reflection. This process is common to normal optical fibers. parable. However, the air is passed on to reduce absorption. Furthermore, the critical angles for the total reflection of X-rays are extremely small, so that only small curvatures of the X-ray fibers are possible.
  • X-ray fibers are made of glass, the inner diameters of the capillaries are in the ⁇ m range. They can be summarized in bundles. By shaping the bundles in the entrance area, it is possible to detect a large solid angle of the radiation emitted by the tube and to form a parallel x-ray beam therefrom.
  • the X-ray light guides can be embedded in metal cannulas and thus have sufficient stability for percutaneous application to human and animal bodies.
  • stainless steel cannulas sterilization of the cannulas is possible by known methods, which would allow multiple use of the X-ray fibers.
  • the capillaries can be closed off by radiolucent windows, which prevent bodily fluids from entering the capillaries. Diffusers of the invention placed on the cannulas (diffuser tips I scatterers) can be used for the isotropic distribution of the radiation.
  • the geometry of the scattering body described above can be adapted so that a uniform radiation emission occurs over the length.
  • the concentration of the particles in the scattering body can vary along the axis of the x-radiation irradiated onto the scattering body.
  • a variation of the particle type along the axis of the X-ray radiation irradiated onto the scattering body can also be provided for beam shaping.
  • the total length of the diffuser the choice of materials or mixtures of materials for particles, for matrix and for a limiting body conceivable around the diffuser, the particle concentration and the matrix properties can be used to determine how much X-radiation the diffuser faces laterally and in the direction of the diffuser X-ray radiation leaves and thus the radiation distribution around the diffuser are predetermined.
  • the scattering body has a tapered bore tapering distally with respect to the X-ray beam directed towards the diffuser during operation, whereby X-rays impinging on the cone are deflected laterally out of the beam axis by total reflection.
  • this deflected radiation can also be scattered by a diffuser located outside the conical bore.
  • the cone may be lined with a sheet of high refractive index radiation material to reduce the steepness of the cone bore.
  • a structure or a material can also be applied to the surface of the conical bore by deposition processes (crystal lattice, single or multiple coating, or the like) for diffracting X-ray radiation.
  • the target volume is supplied in a suitable manner to substances or substance mixtures which scatter a low-energy radiation introduced into the body via a tubular device or convert it into low-energy radiation by X-ray fluorescence.
  • Low-energy radiation-scattering substances or particles achieve an increase in intensity at the radiation source-oriented interface between non-enriched and enriched with such substances areas by remission, which can be exploited for the achievement of a predetermined radiation dose in the target volume.
  • Fig. 1 a first exemplary embodiment of the invention
  • FIG. 3 shows a third, exemplary embodiment of the invention
  • Fig. 5 a fifth exemplary embodiment of the invention.
  • FIG. 1 shows an x-ray beam (1) originating from an external source, which is low-energy and is guided into the body via suitable devices and is scattered in different directions via a diffuser body (2).
  • the scattered X-rays (3) - here only some are shown by way of example - are distributed isotropically in the target volume by multiple scattering or conversion by fluorescence or both mechanisms.
  • Fig. 2 shows a similar configuration as Fig. 1, wherein the scattering body (4) is geometrically shaped differently - here as an example as a truncated cone - and thereby the X-rays (1) for a material-dependent mean free path between two scattering events more scattering body offers.
  • FIG. 3 shows a geometric change of the scattering body
  • the X-radiation (1) is directed to a conical bore and as a result total reflection occurs at the surface, causing beam deflection.
  • the radiation is passed through a scattering body (5), which the radiation scatters or converts by fluorescence into lower energy radiation, which then emerges as scattered radiation (3) in the target volume.
  • FIG. 4 shows a diffuser constructed of different compositions, which for the drawing is composed of blocks of different composition (6, 7, 8). A gradual transition between the materials compositions is also in accordance with the invention.
  • a scattering body (6) with a substance mixture with a high proportion of X-ray fluorescence generating material is followed by a scattering body (7) with a low scattering concentration and closed by a scattering body (8) with a high scattering body concentration shown.
  • the radiation is differently influenced and delivered to the surrounding target volume as scattered radiation (3).
  • the shape of the isodose lines is predictable through the design and choice of material composition.
  • Fig. 5 shows another embodiment of the scattering or X-ray fluorescent substances.
  • the radiation which is either low energy and then passes through an exit window (10) without significant interference, or optionally higher energy and is converted via a fluorescent target in low-energy X-radiation (1) is directed to the target volume.
  • the radiation components (3) not absorbed in the target volume are scattered and redirected to the target volume, or X-ray-fluorescing and the radiation is converted into still therapeutically-biologically effective X-radiation.
  • This enhancement effect increases the dose in the target area and reduces the risk of damage to the blood vessel.
  • the Aufsurgiti- tion of the target volume with said substance in order to achieve the enhancement effect via an increase in intensity by this saturation with scattering material.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un dispositif de rayonnement d'un volume cible à l'intérieur d'un corps, le dispositif étant constitué de façon à diffuser le rayonnement conduit vers le dispositif de façon uniforme à rotation symétrique dans une direction longitudinale de rayonnement des rayons X dirigé sur le dispositif ou à rayonner par fluorescence des rayons X.
PCT/EP2007/059595 2006-09-12 2007-09-12 Pointe de diffuseur pour répartition homogène du rayonnement de rayons x faiblement énergétique dans un milieu Ceased WO2008031853A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112007002080T DE112007002080A5 (de) 2006-09-12 2007-09-12 Diffusor-Spitze zur homogenen Strahlungsverteilung von niederenergetischer Röntgenstrahlung in einem Medium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200610043551 DE102006043551A1 (de) 2006-09-12 2006-09-12 Diffusor-Spitze zur homogenen Strahlungsverteilung von niederenergetischer Röntgenstrahlung in einem Medium
DE102006043551.6 2006-09-12

Publications (1)

Publication Number Publication Date
WO2008031853A1 true WO2008031853A1 (fr) 2008-03-20

Family

ID=38814669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/059595 Ceased WO2008031853A1 (fr) 2006-09-12 2007-09-12 Pointe de diffuseur pour répartition homogène du rayonnement de rayons x faiblement énergétique dans un milieu

Country Status (2)

Country Link
DE (2) DE102006043551A1 (fr)
WO (1) WO2008031853A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020039955A1 (ja) * 2018-08-24 2021-03-11 日立オートモティブシステムズ株式会社 燃料噴射弁

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011108508A1 (de) * 2011-07-25 2013-01-31 Carl Zeiss Meditec Ag Anpassung eines Strahlungsfelds
DE102011110615A1 (de) * 2011-08-16 2013-02-21 Carl Zeiss Meditec Ag Erzeugung einer definierten Strahlungsdosisleistungskurve

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854287A1 (de) * 1998-11-19 2000-06-08 Juergen Leonhardt Vorrichtung zur Verhinderung der Restenose nach Angioplastie mittels Röntgenstrahlung
US20020003856A1 (en) * 2000-02-02 2002-01-10 George Gutman X-ray system with implantable needle for treatment of cancer
US20040013230A1 (en) * 2001-09-19 2004-01-22 Kumakhov Muradin Abubekirovich Device for radiation therapy
US20050226378A1 (en) * 2004-04-06 2005-10-13 Duke University Devices and methods for targeting interior cancers with ionizing radiation
US20060133575A1 (en) * 2004-12-21 2006-06-22 Advanced X-Ray Technology, Inc. X-ray needle apparatus and method for radiation treatment

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854287A1 (de) * 1998-11-19 2000-06-08 Juergen Leonhardt Vorrichtung zur Verhinderung der Restenose nach Angioplastie mittels Röntgenstrahlung
US20020003856A1 (en) * 2000-02-02 2002-01-10 George Gutman X-ray system with implantable needle for treatment of cancer
US20040013230A1 (en) * 2001-09-19 2004-01-22 Kumakhov Muradin Abubekirovich Device for radiation therapy
US20050226378A1 (en) * 2004-04-06 2005-10-13 Duke University Devices and methods for targeting interior cancers with ionizing radiation
US20060133575A1 (en) * 2004-12-21 2006-06-22 Advanced X-Ray Technology, Inc. X-ray needle apparatus and method for radiation treatment

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020039955A1 (ja) * 2018-08-24 2021-03-11 日立オートモティブシステムズ株式会社 燃料噴射弁
CN112567125A (zh) * 2018-08-24 2021-03-26 日立汽车系统株式会社 燃料喷射阀

Also Published As

Publication number Publication date
DE102006043551A1 (de) 2008-03-27
DE112007002080A5 (de) 2009-08-06

Similar Documents

Publication Publication Date Title
DE102004057726B4 (de) Medizinische Untersuchungs- und Behandlungseinrichtung
DE3323365C2 (de) Verfahren und Vorrichtung zur Ausleuchtung von Hohlräumen
DE69531855T2 (de) Röntgenstrahlungsquelle mit flexibler sonde
DE102008009765B4 (de) Bestimmen von Steuerparametern einer Bestrahlungsanlage für eine Bestrahlung eines Zielvolumens
DE102008041286A1 (de) Ballonkatheter und Röntgenapplikator mit einem Ballonkatheter
DE102009039345A1 (de) Vorrichtung zur Bestrahlungsfeldkontrolle bei radiologischen Strahlentherapiegeräten
EP2189184B1 (fr) Dispositif et procédé de réduction de l'élargissement de rayon d'un rayonnement
DE102008030590A1 (de) Applikator zur Verwendung in einer Strahlentherapievorrichtung sowie Strahlentherapievorrichtung
DE10140099A1 (de) Verfahren und System zum Liefern von Strahlung an einen Behandlungsbereich
DE102007018102B4 (de) Einrichtung zur strahlentherapeutischen Behandlung von Gewebe mittels einer Röntgen-CT-Anlage oder einer diagnostischen oder Orthovolt-Röntgen-Anlage
DE102011108508A1 (de) Anpassung eines Strahlungsfelds
WO2010006722A1 (fr) Radiothérapie à l'aide de tubes à haute puissance, renforcée par des produits de contraste
WO2008031853A1 (fr) Pointe de diffuseur pour répartition homogène du rayonnement de rayons x faiblement énergétique dans un milieu
DE10232928B4 (de) Bestrahlungsvorrichtung sowie entfernbarer Elektronenkollimator
DE102011110615A1 (de) Erzeugung einer definierten Strahlungsdosisleistungskurve
DE102018120750B3 (de) Applikator für ein medizinisches Strahlentherapiesystem und Verfahren zum Kalibrieren eines solchen
DE10041473B9 (de) Vorrichtung zur Bestrahlung von Gewebe
DE102007060189A1 (de) Strahlentherapievorrichtung und Verfahren zur Steuerung einer Strahlentherapievorrichtung
DE112013004939T5 (de) Tumortherapie mittels zielgerichteter Kernfusion
DE102010009019B4 (de) Medizinisches, mit Röntgenstrahlen arbeitendes Gerät sowie Verfahren zum Betreiben eines solchen
WO2014075700A1 (fr) Source de rayons x, collimateur, poste de travail radiologique et procédé permettant leur fonctionnement
DE102011004224A1 (de) Strahlentherapieanlage mit einem Teleskoparm
DE19731307C1 (de) Vorrichtung zur Bestrahlung von Gewebe
DE10341538A1 (de) Röntgenquelle
DE102010020352A1 (de) Verfahren zum Erzeugen und/oder Bereitstellen von Daten für eine Gewebebehandlung

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07820156

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 1120070020806

Country of ref document: DE

REF Corresponds to

Ref document number: 112007002080

Country of ref document: DE

Date of ref document: 20090806

Kind code of ref document: P

122 Ep: pct application non-entry in european phase

Ref document number: 07820156

Country of ref document: EP

Kind code of ref document: A1