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WO2008031113A3 - Improved method for inhibition of neovascularization - Google Patents

Improved method for inhibition of neovascularization Download PDF

Info

Publication number
WO2008031113A3
WO2008031113A3 PCT/US2007/078080 US2007078080W WO2008031113A3 WO 2008031113 A3 WO2008031113 A3 WO 2008031113A3 US 2007078080 W US2007078080 W US 2007078080W WO 2008031113 A3 WO2008031113 A3 WO 2008031113A3
Authority
WO
WIPO (PCT)
Prior art keywords
neovascularization
inhibition
improved method
squalamine
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/078080
Other languages
French (fr)
Other versions
WO2008031113A2 (en
WO2008031113A8 (en
Inventor
Michael Mclane
Andrew V Albright
Hsiao-Ling Hung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genaera Corp
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Publication of WO2008031113A2 publication Critical patent/WO2008031113A2/en
Publication of WO2008031113A8 publication Critical patent/WO2008031113A8/en
Publication of WO2008031113A3 publication Critical patent/WO2008031113A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a use of the aminosterol compound squalamine for the inhibition of neovascularization as an improved method for the treatment of macular degeneration, cancer and other diseases associated with inappropriate neovascularization in an individual diagnosed with hypertension.
PCT/US2007/078080 2006-09-08 2007-09-10 Improved method for inhibition of neovascularization Ceased WO2008031113A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84294106P 2006-09-08 2006-09-08
US60/842,941 2006-09-08

Publications (3)

Publication Number Publication Date
WO2008031113A2 WO2008031113A2 (en) 2008-03-13
WO2008031113A8 WO2008031113A8 (en) 2008-05-22
WO2008031113A3 true WO2008031113A3 (en) 2008-07-10

Family

ID=39158141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078080 Ceased WO2008031113A2 (en) 2006-09-08 2007-09-10 Improved method for inhibition of neovascularization

Country Status (1)

Country Link
WO (1) WO2008031113A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2953138B1 (en) * 2009-12-02 2015-10-16 Assist Publ Hopitaux Marseille AMINOSTEROIDAL COMPOUNDS FOR LOCAL TOPICAL APPLICATION FOR CUTANEO-MUCOUS DECOLONIZATION OF STAPHYLOCOCCUS AUREUS
US20130281420A1 (en) * 2010-08-17 2013-10-24 Ohr Pharmaceutical, Inc. Ophthalmic Formulations of Squalamine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544761B2 (en) * 1994-12-13 2003-04-08 Human Genome Sciences, Inc. Human tissue inhibitor of metalloproteinase-4

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544761B2 (en) * 1994-12-13 2003-04-08 Human Genome Sciences, Inc. Human tissue inhibitor of metalloproteinase-4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SHEPHERD F. ET AL.: "Angiongenesis Inhibitors Under Study for the Treatment of Lung Cancer", vol. 41, 2003, pages S63 - S72 *
ZHOU X.-D. ET AL.: "A New Highly Stereoselective Construction of the Sidechain of squalamine Through Improved Sharpless Catalytic Asymetric Dihydroxylation", vol. 42, 2001, pages 2537 - 2539 *

Also Published As

Publication number Publication date
WO2008031113A2 (en) 2008-03-13
WO2008031113A8 (en) 2008-05-22

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