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WO2008028060A3 - Anti-tumor compounds for inhibiting cancer growth - Google Patents

Anti-tumor compounds for inhibiting cancer growth Download PDF

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Publication number
WO2008028060A3
WO2008028060A3 PCT/US2007/077273 US2007077273W WO2008028060A3 WO 2008028060 A3 WO2008028060 A3 WO 2008028060A3 US 2007077273 W US2007077273 W US 2007077273W WO 2008028060 A3 WO2008028060 A3 WO 2008028060A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
triterpenoidal
groups
triterpenoid
sapongenin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/077273
Other languages
French (fr)
Other versions
WO2008028060A9 (en
WO2008028060A2 (en
WO2008028060B1 (en
Inventor
Pui-Kwong Chan
May Sung Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Arrow Ltd
Original Assignee
Pacific Arrow Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd
Priority to EP07841638A priority Critical patent/EP2061798A4/en
Priority to CN200780040744.4A priority patent/CN101553497B/en
Priority to CA002676791A priority patent/CA2676791A1/en
Priority to EP08725693A priority patent/EP2121715A4/en
Priority to SG2012011029A priority patent/SG178795A1/en
Priority to PCT/US2008/002086 priority patent/WO2008133766A1/en
Priority to CN200880012065A priority patent/CN101772511A/en
Priority to JP2009550096A priority patent/JP2010519219A/en
Priority to AU2008244648A priority patent/AU2008244648A1/en
Publication of WO2008028060A2 publication Critical patent/WO2008028060A2/en
Publication of WO2008028060A9 publication Critical patent/WO2008028060A9/en
Publication of WO2008028060A3 publication Critical patent/WO2008028060A3/en
Publication of WO2008028060B1 publication Critical patent/WO2008028060B1/en
Anticipated expiration legal-status Critical
Priority to AU2009200988A priority patent/AU2009200988B2/en
Priority to US12/856,322 priority patent/US8586719B2/en
Priority to US13/841,053 priority patent/US9382285B2/en
Priority to US15/181,631 priority patent/US10213451B2/en
Priority to US16/285,634 priority patent/US11046724B2/en
Priority to US17/362,028 priority patent/US20220024961A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

This invention provides a method for treating cancer by blocking the migration, metastasis of cancer cells, growth of cancers wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. This invention provides uses of compositions comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal sapogenin, triterpenoid, triterpenoidal compound or other sapongenin backbones.
PCT/US2007/077273 2003-10-09 2007-08-30 Anti-tumor compounds for inhibiting cancer growth Ceased WO2008028060A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
EP07841638A EP2061798A4 (en) 2006-09-01 2007-08-30 Anti-tumor compounds for inhibiting cancer growth
CN200780040744.4A CN101553497B (en) 2006-09-01 2007-08-30 Antitumor compounds capable of inhibiting cancer cell growth
AU2008244648A AU2008244648A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
EP08725693A EP2121715A4 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
SG2012011029A SG178795A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
CA002676791A CA2676791A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
PCT/US2008/002086 WO2008133766A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
CN200880012065A CN101772511A (en) 2007-02-16 2008-02-15 Prevention of cancer cell metastasis and new compounds and their applications by affecting the expression of adhesion proteins
JP2009550096A JP2010519219A (en) 2007-02-16 2008-02-15 Blocking cancer cell migration or metastasis by affecting adhesion proteins and use of the novel compounds
AU2009200988A AU2009200988B2 (en) 2003-10-09 2009-03-10 Anti-tumor compounds for inhibiting cancer growth
US12/856,322 US8586719B2 (en) 2005-04-27 2010-08-13 Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US13/841,053 US9382285B2 (en) 2004-09-07 2013-03-15 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US15/181,631 US10213451B2 (en) 2004-09-07 2016-06-14 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US16/285,634 US11046724B2 (en) 2004-09-07 2019-02-26 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US17/362,028 US20220024961A1 (en) 2004-09-07 2021-06-29 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84172706P 2006-09-01 2006-09-01
US60/841,727 2006-09-01
US89038007P 2007-02-16 2007-02-16
US60/890,380 2007-02-16

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/016158 Continuation-In-Part WO2006116656A2 (en) 2003-10-09 2006-04-27 Compositions comprising triterpene saponins and compounds with functional angeloyl groups for inhibition of venous insufficiency, leg swelling and tumors
US11/683,198 Continuation-In-Part US8614197B2 (en) 2003-10-09 2007-03-07 Anti-tumor compounds with angeloyl groups

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2008/002086 Continuation-In-Part WO2008133766A1 (en) 2004-09-07 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
AU2009200988A Division AU2009200988B2 (en) 2003-10-09 2009-03-10 Anti-tumor compounds for inhibiting cancer growth

Publications (4)

Publication Number Publication Date
WO2008028060A2 WO2008028060A2 (en) 2008-03-06
WO2008028060A9 WO2008028060A9 (en) 2008-07-17
WO2008028060A3 true WO2008028060A3 (en) 2008-10-23
WO2008028060B1 WO2008028060B1 (en) 2008-11-20

Family

ID=39136898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077273 Ceased WO2008028060A2 (en) 2003-10-09 2007-08-30 Anti-tumor compounds for inhibiting cancer growth

Country Status (3)

Country Link
EP (1) EP2061798A4 (en)
CN (1) CN101553497B (en)
WO (1) WO2008028060A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524824B2 (en) 2003-09-04 2009-04-28 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US7727561B2 (en) 2001-08-31 2010-06-01 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US7514412B2 (en) 2003-10-09 2009-04-07 Pacific Arrow Limited Anticancer biangeloyl saponins
US7488753B2 (en) 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
US8735558B2 (en) 2005-02-14 2014-05-27 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US9382285B2 (en) 2004-09-07 2016-07-05 Pacific Arrow Limited Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US8586719B2 (en) 2005-04-27 2013-11-19 Pacific Arrow Limited Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
EP2121715A4 (en) * 2007-02-16 2010-12-29 Pacific Arrow Ltd Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US9434677B2 (en) 2009-07-16 2016-09-06 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
US9499577B2 (en) 2009-07-16 2016-11-22 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
US20120277308A1 (en) 2010-07-16 2012-11-01 Pacific Arrow Limited compounds for treating cancer and other diseases
CA2805136C (en) * 2010-07-16 2021-06-08 Pacific Arrow Limited New compounds for treating cancer and other diseases
ES2666133T3 (en) 2015-02-27 2018-05-03 Warszawski Uniwersytet Medyczny Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound
EP3949957A4 (en) * 2019-03-26 2022-12-28 National University Corporation Kagawa University PHARMACEUTICAL COMPOSITION FOR INJECTION INTO AN ORGAN CAVITY OF THE URINARY TRACT FOR THE PREVENTION OR TREATMENT OF UROTHELIAL CANCER

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037200A2 (en) * 2001-10-31 2003-05-08 Centerpulse Spine-Tech, Inc. Adjustable tandem connectors for corrective devices for the spinal column and other bones and joints
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7488753B2 (en) * 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
CN101242850B (en) * 2003-10-09 2013-03-20 太平洋艾瑞有限公司 Compositions, functions and uses of xanthoceras sorbifolia extract and compounds isolated therefrom, and methods of making same
TWI454269B (en) * 2003-12-23 2014-10-01 Pacific Arrow Ltd Compound isolated from XANTHOCERAS SORBIFOLIA, preparation method thereof and use thereof
JP5087400B2 (en) * 2004-09-07 2012-12-05 パシフィック アロー リミテッド Antitumor compounds having an angeloyl group
US20080221120A1 (en) * 2005-03-23 2008-09-11 Alan Verkman Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same
WO2003037200A2 (en) * 2001-10-31 2003-05-08 Centerpulse Spine-Tech, Inc. Adjustable tandem connectors for corrective devices for the spinal column and other bones and joints

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D'ACQUARICA ET AL.: "Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira AIT", TETRAHEDRON, vol. 58, 2002, pages 10127 - 10136, XP004396869 *
See also references of EP2061798A4 *
SEO ET AL.: "A New Triterpene Saponin from Pittosporum viridiflorum from the Madagascar Rainforest", JOURNAL OF NATURAL PRODUCTS, vol. 65, 2002, pages 65 - 68, XP002510555 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups

Also Published As

Publication number Publication date
CN101553497B (en) 2013-03-27
WO2008028060A9 (en) 2008-07-17
EP2061798A4 (en) 2009-11-11
EP2061798A2 (en) 2009-05-27
WO2008028060A2 (en) 2008-03-06
CN101553497A (en) 2009-10-07
WO2008028060B1 (en) 2008-11-20

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