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WO2008025111A3 - Biodegradable device for intraocular drug delivery - Google Patents

Biodegradable device for intraocular drug delivery Download PDF

Info

Publication number
WO2008025111A3
WO2008025111A3 PCT/BR2007/000222 BR2007000222W WO2008025111A3 WO 2008025111 A3 WO2008025111 A3 WO 2008025111A3 BR 2007000222 W BR2007000222 W BR 2007000222W WO 2008025111 A3 WO2008025111 A3 WO 2008025111A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
drug delivery
biodegradable device
biodegradable
intraocular drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2007/000222
Other languages
French (fr)
Other versions
WO2008025111A8 (en
WO2008025111A2 (en
Inventor
Silva Cunha Junior Armando Da
Siqueira Rubens Camargo
Fialho Silvia Ligorio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal de Minas Gerais
Original Assignee
Universidade Federal de Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal de Minas Gerais filed Critical Universidade Federal de Minas Gerais
Publication of WO2008025111A2 publication Critical patent/WO2008025111A2/en
Publication of WO2008025111A3 publication Critical patent/WO2008025111A3/en
Publication of WO2008025111A8 publication Critical patent/WO2008025111A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

This invention is related to the production process of a pharmaceutical formulation that can treat retinal degenerations and diseases of the posterior segment of the eye, such as diabetic retinopathy, age-related macular degeneration, retinitis by cytomegalovirus, endophthalmitis and uveitis. Said formulation comprises a monolithic system of the drug composed by a biodegradable matrix of a polymer of the polyester class. The said formulation is applicable for the intraocular route. This biodegradable device can deliver one or more drugs, such as dexamethasone, prednisolone and triamcinolone, nonsteroidal antiinflammatory drugs, antibiotics, immunosuppressive agents and antiproliferative agents.
PCT/BR2007/000222 2006-08-31 2007-08-31 Biodegradable device for intraocular drug delivery Ceased WO2008025111A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0604577A BRPI0604577B8 (en) 2006-08-31 2006-08-31 pharmaceutical formulation for intraocular drug administration and procurement process
BRPI0604577-4 2006-08-31

Publications (3)

Publication Number Publication Date
WO2008025111A2 WO2008025111A2 (en) 2008-03-06
WO2008025111A3 true WO2008025111A3 (en) 2008-04-17
WO2008025111A8 WO2008025111A8 (en) 2008-05-29

Family

ID=38987981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2007/000222 Ceased WO2008025111A2 (en) 2006-08-31 2007-08-31 Biodegradable device for intraocular drug delivery

Country Status (2)

Country Link
BR (1) BRPI0604577B8 (en)
WO (1) WO2008025111A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10588855B2 (en) * 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
BR102012009316A2 (en) * 2012-04-20 2013-11-26 Univ Minas Gerais PROLONGED THAIDOMIDE RELEASE DEVICE AND USE IN EYE DISEASES CAUSING NEOVASCULARIZATION
JP6543431B2 (en) * 2013-10-10 2019-07-10 ユニバーシティー オブ ユタ リサーチ ファウンデーションＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｕｔａｈ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Intraocular drug delivery device and associated method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726918B1 (en) * 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726918B1 (en) * 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FIALHO S L ET AL: "Safety and pharmacokinetics of an intravitreal biodegradable implant of dexamethasone acetate in rabbit eyes", CURRENT EYE RESEARCH 01 JUL 2006 UNITED KINGDOM, vol. 31, no. 6, 1 July 2006 (2006-07-01), pages 525 - 534, XP009095740, ISSN: 0271-3683 1460-2202 *
SILVIA LIGORIO FIALHO ET AL: "MANUFACTURING TECHNIQUES OF BIODEGRADABLE IMPLANTS INTENDED FOR INTRAOCULAR APPLICATION", DRUG DELIVERY, ACADEMIC PRESS, ORLANDO, FL, US, vol. 12, no. 2, April 2005 (2005-04-01), pages 109 - 116, XP009062531, ISSN: 1071-7544 *

Also Published As

Publication number Publication date
WO2008025111A8 (en) 2008-05-29
BRPI0604577B8 (en) 2021-05-25
WO2008025111A2 (en) 2008-03-06
BRPI0604577A (en) 2008-04-22
BRPI0604577B1 (en) 2020-11-24

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