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WO2008018084A3 - Peptides dérivés d'un inhibiteur de l'activateur du plasminogène pour prévenir un dommage neuronal - Google Patents

Peptides dérivés d'un inhibiteur de l'activateur du plasminogène pour prévenir un dommage neuronal Download PDF

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Publication number
WO2008018084A3
WO2008018084A3 PCT/IL2007/001007 IL2007001007W WO2008018084A3 WO 2008018084 A3 WO2008018084 A3 WO 2008018084A3 IL 2007001007 W IL2007001007 W IL 2007001007W WO 2008018084 A3 WO2008018084 A3 WO 2008018084A3
Authority
WO
WIPO (PCT)
Prior art keywords
plasminogen activator
activator inhibitor
neuronal damage
preventing neuronal
peptides derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2007/001007
Other languages
English (en)
Other versions
WO2008018084A2 (fr
Inventor
Abd Al-Roof Higazi
Douglas B Cines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thrombotech Ltd
University of Pennsylvania Penn
Original Assignee
Thrombotech Ltd
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thrombotech Ltd, University of Pennsylvania Penn filed Critical Thrombotech Ltd
Publication of WO2008018084A2 publication Critical patent/WO2008018084A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008018084A3 publication Critical patent/WO2008018084A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des utilisations thérapeutiques de peptides comprenant six résidus d'acides aminés dérivés des acides aminés 350-355 de l'inhibiteur 1 de l'activateur du plasminogène humain (PAI-1) pour prévenir un dommage neuronal dû en particulier à un accident cérébrovasculaire hypoxique ou thrombo-embolique et à une lésion cérébrale.
PCT/IL2007/001007 2006-08-10 2007-08-12 Peptides dérivés d'un inhibiteur de l'activateur du plasminogène pour prévenir un dommage neuronal Ceased WO2008018084A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83666506P 2006-08-10 2006-08-10
US60/836,665 2006-08-10

Publications (2)

Publication Number Publication Date
WO2008018084A2 WO2008018084A2 (fr) 2008-02-14
WO2008018084A3 true WO2008018084A3 (fr) 2009-05-07

Family

ID=39033391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/001007 Ceased WO2008018084A2 (fr) 2006-08-10 2007-08-12 Peptides dérivés d'un inhibiteur de l'activateur du plasminogène pour prévenir un dommage neuronal

Country Status (1)

Country Link
WO (1) WO2008018084A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008278568B2 (en) 2007-07-24 2013-08-01 D-Pharm Ltd. Peptides derived from plasminogen activator inhibitor-1 and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US20040254115A1 (en) * 1997-10-17 2004-12-16 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator

Also Published As

Publication number Publication date
WO2008018084A2 (fr) 2008-02-14

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