[go: up one dir, main page]

WO2008016811A3 - Aminopipéridines et composés apparentés - Google Patents

Aminopipéridines et composés apparentés Download PDF

Info

Publication number
WO2008016811A3
WO2008016811A3 PCT/US2007/074282 US2007074282W WO2008016811A3 WO 2008016811 A3 WO2008016811 A3 WO 2008016811A3 US 2007074282 W US2007074282 W US 2007074282W WO 2008016811 A3 WO2008016811 A3 WO 2008016811A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
aminopiperidines
realted
methods
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/074282
Other languages
English (en)
Other versions
WO2008016811A2 (fr
Inventor
Manuka Ghosh
Christopher K Seekamp
Xuechun Zhang
James G Tarrant
Che-Wah Lee
Bernd Kaiser
Mary-Margaret Zablocki
Bertrand L Chenard
Dario Doller
Yasuchika Yamaguchi
David J Wustrow
Guiying Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of WO2008016811A2 publication Critical patent/WO2008016811A2/fr
Publication of WO2008016811A3 publication Critical patent/WO2008016811A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des aminopipéridines et des composés apparentés représentés par les formules dans lesquelles des variables sont décrites dans les présentes. De tels composés peuvent être utilisés pour moduler l'activité du récepteur MCH in vivo ou in vitro, et sont particulièrement utiles dans le traitement d'une diversité de troubles métaboliques, de l'alimentation et sexuels chez les êtres humains, les animaux de compagnie domestiqués et les animaux de bétail. L'invention concerne des compositions pharmaceutiques et des procédés pour traiter de tels troubles, ainsi que des procédés pour utiliser de tels ligands pour détecter les récepteurs MCH (par exemple, études de l'emplacement des récepteurs).
PCT/US2007/074282 2006-07-31 2007-07-25 Aminopipéridines et composés apparentés Ceased WO2008016811A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82083406P 2006-07-31 2006-07-31
US60/820,834 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008016811A2 WO2008016811A2 (fr) 2008-02-07
WO2008016811A3 true WO2008016811A3 (fr) 2008-10-09

Family

ID=38997770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074282 Ceased WO2008016811A2 (fr) 2006-07-31 2007-07-25 Aminopipéridines et composés apparentés

Country Status (1)

Country Link
WO (1) WO2008016811A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
KR20100124262A (ko) 2008-02-13 2010-11-26 에자이 알앤드디 매니지먼트 가부시키가이샤 비시클로아민 유도체
AU2009223693A1 (en) * 2008-03-14 2009-09-17 Exelixis, Inc. Azabicyclo [3.2.1] octyl derivatives as 11 beta-HSD1 modulators
EP2272841A1 (fr) * 2008-03-28 2011-01-12 Banyu Pharmaceutical Co., Ltd. Dérivé de diarylméthylamide à activité antagoniste sur un récepteur d'hormone concentrant la mélanine
MY157597A (en) 2008-04-11 2016-06-30 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
WO2010050456A1 (fr) * 2008-10-30 2010-05-06 萬有製薬株式会社 Composé pipéridine ayant une structure di- ou tri-arylméthyle
AU2010249041B2 (en) 2009-05-14 2014-11-13 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase
WO2011053688A1 (fr) * 2009-10-29 2011-05-05 Schering Corporation Dérivés de pipéridine bicycliques pontés et leurs procédés d'utilisation
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
CN105130967B (zh) 2011-05-13 2018-04-17 阵列生物制药公司 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
MX365733B (es) 2012-11-13 2019-06-12 Array Biopharma Inc Compuestos de n-pirrolidinil, n' -pirazolil-urea, tiourea, guanidina y cianoguanidina como inhibidores de trka cinasa.
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9828360B2 (en) 2012-11-13 2017-11-28 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078328A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9790210B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078417A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de pyrazolylurée, d'urée, de thiourée, de guanidine et de cyanoguianidine en tant qu'inhibiteurs de la trka kinase
ES2610975T3 (es) 2012-11-13 2017-05-04 Array Biopharma, Inc. Compuestos bicíclicos de urea, tiourea, guanidina y cianoguanidina útiles para el tratamiento del dolor
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9169214B2 (en) * 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
EP3053911B1 (fr) * 2013-09-30 2020-01-22 The University of Tokyo Composé activateur du récepteur de l'adiponectine
MX2016014945A (es) 2014-05-15 2017-03-27 Array Biopharma Inc 1- ((3s,4r) -4- (3-fluorofenil) -1- (2-metoxietil) pirrolidin-3-il) -3- (4-metil-3- (2-metilpirimidin-5-il) -1-fenil-1h-pirazol-5-il) urea como inhibidor de trka cinasa.
EP3179857B1 (fr) 2014-08-14 2021-09-08 Mamoun M. Alhamadsheh Conjugaison d'agents pharmaceutiquement actifs avec des ligands de transthyrétine par des liants réglables pour augmenter la demi-vie de sérum
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
WO2019008507A1 (fr) * 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited Dérivés de 2-(4-chlorophénoxy)-n-((1-(2-(4-chlorophénoxy)éthynazétidine-3-yl)méthyl)acétamide et composés apparentés servant d'inhibiteurs d'atf4 pour le traitement du cancer et d'autres maladies
EP3682906A1 (fr) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Composé ciblant le transporteur de norépinéphrine
KR20240027076A (ko) * 2021-07-26 2024-02-29 조에티스 서비시즈 엘엘씨 세로토닌 5-ht2b 억제 화합물
CN115124473B (zh) * 2022-07-12 2023-11-10 河北科技大学 西咪替丁有关物质b的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028616A (en) * 1989-09-05 1991-07-02 G. D. Searle & Co. N-benzylpiperidine amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028616A (en) * 1989-09-05 1991-07-02 G. D. Searle & Co. N-benzylpiperidine amides

Also Published As

Publication number Publication date
WO2008016811A2 (fr) 2008-02-07

Similar Documents

Publication Publication Date Title
WO2008016811A3 (fr) Aminopipéridines et composés apparentés
WO2005110982A3 (fr) Analogues substitues 1-benzyl-4-substitues piperazine
WO2009012482A3 (fr) Amides heterocycliques a 5 chainons et composes associes
MY148461A (en) Heteroaryl amide analogues as p2x7 antagonists
MY150731A (en) Heteroaryl amide derivatives
WO2007133561A3 (fr) Dérivés azaspiro substitués
TW200716594A (en) Substituted heteroaryl CB1 antagonists
WO2006009789A3 (fr) Derives piperazine a substitution aryle
WO2007146122A3 (fr) Tétrahydropyrido[3,4-d]pyrimidines et analogues associés
WO2009003003A3 (fr) Composés de pipérazinyl oxoalkyl tétrahydro-bêta-carbolines et analogues apparentés
WO2006078992A3 (fr) Analogues de piperazinyl-pyridine à substitution hétéroaryle
WO2007140383A3 (fr) Sulfonamides spirocycliques et composés apparentés
WO2008024433A3 (fr) Dérivés de la pyrimidinone substitués par un halogénoalkyle
WO2007106349A3 (fr) Pipérazinyl-oxoalkyl-tétrahydroisoquinoléines et analogues apparentés
WO2008024438A3 (fr) Analogues de la 2-phénoxypyrimidinone
WO2009039431A3 (fr) Amines spirocycliques aryl-condensées substituées
WO2005007652A3 (fr) Analogues de quinoline-4-ylamine substituee
WO2008066664A3 (fr) Dérivés de pyrimidinone substitués par cis-cyclohexyle
WO2006026135A3 (fr) Analogues de biaryle pipérazinyl-pyridine substitués
WO2008033739A3 (fr) Dérivés de benzimidazolecarboxamide
WO2006076646A3 (fr) Analogues de quinolin-4-ylamine à substitution hétéroaryle
WO2006081388A3 (fr) Analogues de pyridazinyl-et de pyrimidinyl-quinolin-4-ylamine substitues
WO2009100120A3 (fr) Pipérazinyl-oxoéthyl-tétrahydropyrazolopyridines substituées par du pyridinyle
WO2006089076A3 (fr) Thiazole amides, imidazole amides et analogues associes
WO2006042289A3 (fr) Analogues de biaryl quinoline-4-ylamine a substitution

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07813321

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07813321

Country of ref document: EP

Kind code of ref document: A2