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WO2008015699A2 - Procédé de fabrication d'une composition à base d'herbes pour soigner le diabète et composition à base d'herbes obtenue à partir de ce procédé - Google Patents

Procédé de fabrication d'une composition à base d'herbes pour soigner le diabète et composition à base d'herbes obtenue à partir de ce procédé Download PDF

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Publication number
WO2008015699A2
WO2008015699A2 PCT/IN2007/000215 IN2007000215W WO2008015699A2 WO 2008015699 A2 WO2008015699 A2 WO 2008015699A2 IN 2007000215 W IN2007000215 W IN 2007000215W WO 2008015699 A2 WO2008015699 A2 WO 2008015699A2
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WIPO (PCT)
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weight
extract
herbal composition
leaf extract
fruit extract
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Ceased
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PCT/IN2007/000215
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English (en)
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WO2008015699A3 (fr
Inventor
Babulal Bhawarlal Jain
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Publication of WO2008015699A3 publication Critical patent/WO2008015699A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • a Process for manufacturing an herbal composition for curing Diabetes and herbal composition made thereof
  • the present invention relates to process for manufacturing an herbal composition for curing Diabetes. Also it relates to an herbal composition manufactured by the aforesaid process.
  • Diabetes mellitus is a worldwide problem with increasing number of affected population. Diabetes mellitus, in view of Western medicinal science, is characterized by- failure in glucose metabolism which is due to absolute or insufficient insulin production, or relative insensitivity to insulin which is the key hormone for glucogenesis. In people with diabetes, the pancreas produces little or no insulin, the hormone responsible for facilitating uptake of glucose by cells to give energy as ATP, resulting in a high level of glucose in the blood, causing excessive urination and constant thirst and hunger.
  • Type I diabetes mellitus There are two main types of diabetes mellitus, Type I and Type II.
  • Type I the more severe form and accounts for 5 to 10 percent diabetes, the body does not produce any insulin, most often occurring in children and young adults. Without regular injections of insulin the sufferer lapses into a coma and dies. Individuals suffering from Type I diabetes are totally insulin dependent.
  • Type II diabetes the most prevalent type of diabetes, is usually of gradual onset and occurs mainly in people over 40.
  • Type II diabetes is a metabolic disorder resulting from the body's inability to make enough, or properly use, insulin to meet the body's needs, especially when the person is overweight. It is the most common form of the disease.
  • Type II diabetes accounts for 90 to 95 percent of diabetes.
  • Type II diabetes is nearing epidemic proportions due to a greater prevalence of obesity and sedentary lifestyles. Initially, the combination of dietary measures, weight reduction and oral medication can keep the condition under control for a period of time, but most people with Type II diabetes ultimately require insulin injections.
  • diabetes Medical complications arise from diabetes include athreosclerosis, hyperlipidemia, retinal damage, neurological damage, and blindness.
  • the trigger of the cause of diabetes is remained unknown and the common treatments include oral intake of medicine and insulin injection to restore the relative sensitivity to the insulin or supply a source of insulin for use. These treatments are for managing and control of the glucose level and ineffective in curing the disease and improving the gravity of the disease.
  • Diet management is another contemporary method for treating diabetes. Since the glucose cycle in our body is affected, the uptake of sugar, ranging from monosaccharide, disaccharide and polysaccharide requires special monitoring. However, glucose is the major energy source of our body, any deficiency or excess of glucose is not good to our body. Thus, careful glucose control is required if the disease is not cured.
  • Heracleum lanatum is one of the natural herbs which is used for treatment in diabetes.
  • U.S. Pat. No. 5,741,491 the use of an extract derived from Heracleum lanatum and a specie of Populus is disclosed wherein the direct relation between the administration of the extract and the effect of lowering blood glucose was shown.
  • there must still much room for further development or breakthrough in the field of herbs science, especially with the increasing knowledge and understandings of tradition Chinese medicine and herbs, for treatment of diabetes partly because existing methods of treatment of diabetes are not really curing the disease and partly because the ever growing number of people are suffered from this disease.
  • Pregrant 20050175716 discloses a method and herbal composition of treatment for diabetes comprising the steps of providing a predetermined herbal composition in a predetermined form, providing an administration plan for a predetermined number of days; and administering the herbal composition according to the administration plan for a predetermined number of days.
  • the herbal composition comprises Toona sinensis and Heracleum lanatum which is natural and does not have any adverse side effects.
  • Toona sinensis is the major active ingredient for treatment of diabetes while Heracleum lanatum is used to provide an optimum body conditions for treatment.
  • U.S. Pat. No. 5,945,107 describes compositions and methods containing herbal plant extracts for weight reduction.
  • Guarana which contains caffeine, as an active ingredient, has been incorporated into weight loss products (Hurel, J. -P., 1993, FR 2 712 191 -Al).
  • Primez (Belgium Patent 100593A7) describes a phyto-active mixture referred to as Lycopodium, which contains Guarana and other plant extracts including Scillia maritime, Ephedra vulgaris, and Betula alba to produce weight loss.
  • thermogenic substance Dietary supplements containing a thermogenic substance, an adrenal support substance, thyrogenic substance and a blood sugar regulation substance are disclosed in U.S. Pat. No. 6,277,396.
  • the thermogenic substance to increase metabolism and accelerate calorie expenditures, is selected from a group consisting of caffeine, catechins, MaHuang, ephedrine, synephrine, norephedrine, psuedoephedrine, and White Willow.
  • the adrenal support substance to maintain and/ or improve adrenal functions and to reduce stress, is selected from a group consisting of Cordyceps, Ashwagandha, Astragalus, ginseng, Schisandra, Siberian ginseng, licorice, Asian ginseng, Codonopsis, adrenal glandular extract, embryo extract.
  • the thyrogenic substance, to support and/ or improve thyroid functions is selected from a group consisting of Guggul (guggelsterones), thyroid glandular extract, and tyrosine.
  • the blood sugar regulation substance to regulate or manipulate blood sugar levels and/ or glucose metabolism and to help stabilize normal sugar levels and increase the body's ability to lose stored body fat, is selected from a group consisting of Bitter Melon (Momordica charantia), vanadium, allano lactone, Fenugreek (Trigonella foenumgraecum), Garcinia (Garcinia cambogia), gymnema (Gymnema sylvestra), marshmallow (Althaea officinalis), chromium, chromium GTF, chromium picolinate, chromium polynicotinate, alpha lipoic acid, inula racemusa, zinc, magnesium, cyclo- hispor, Agaricus campestris (mushroom), Medicago sativa (Lucema), pinitol (Bougainvillea spectabilis).
  • U.S. Pat. No. 6,042,834 discloses an herbal composition comprising Trigonella foenumgraecum, Nigella sativa, Origanum vulgare, Rosemarinus officinalis, Lupinus termis, Lawsonia inermis and Foeniculum vulgare for the treatment of diabetes.
  • the conventional Herbal formulations which are available, are not found effective for curing the above diseases. Also they all having up to some extent the risk of side effects. Therefore, there is a need to have different combination in full therapeutic effect of the active ingredients present in the different types of Herbs to give synergy effect with minimal or no side effect. Hence there is a need for a safe and effective treatment for diabetes with minimal side effects and without the invasive procedure, such as insulin injection.
  • the main object of the present invention is to provide a process for manufacturing an herbal composition for curing Diabetes. Further object of present invention is to provide an herbal composition manufactured by the aforesaid mentioned process.
  • Another object is to provide herbal medicament for curing Diabetes with least or no side effect.
  • Another object is to provide herbal medicament for controlling Diabetes in a shorter span of time.
  • a process for manufacturing an herbal composition comprises the steps of: a. selecting the extracts of the following Herbs in the given percentage by weight:
  • Methi Trigonella foenum graecum
  • Kalmegh (Andrographis paniculata)
  • an herbal composition comprises:
  • Methi Trigonella foenum graecum
  • Kalmegh (Andrographis paniculata)
  • the herbal composition is available in powder form.
  • the herbal composition of the present invention essentially comprising of following main ingredients:
  • the leaves are refrigerant, aperients and given internally for biliousness. They are useful in fever, vomiting, flatulence, colic, and dysentery. It makes you every rejuvenate and cooling effect to the body. It controls diabetes. It increases blood levels in the body.
  • This amla powder is rich in vitamin C. This powder improves digestion and set right all your digestive problems. It gives strength to body and good for stomach, heart, and eye and for general health. If this powder is given to a person who is sick, he gets well soon. This is not only used to get relief from phlegm, vomiting sensation but also for many other purposes.
  • an herbal composition comprises the following ingredients in proper amount:
  • Methi Trigonella foenum graecum
  • Kalmegh (Andrographis paniculata)
  • the formulation of the present invention is not a mere admixture resulting in mere aggregation of the properties of individual ingredients but in a synergistic mixture resulting in enhanced curative properties.
  • the clinical trial has been conducted on this newly developed herbal composition and it is surprisingly found that efficacy is improved by using this formulation instead of using individual ingredients of the formulation.
  • the clinical trials have been conducted on the patients suffering from the Diabetes. All have been administered by the formulation of the present invention orally once or twice a da)r depending on the extent of Diabetes and it has been found that patients get cured in a shorter span of time with least or no side effects. Extent of side effect is varying from person to person. No severe side effect is found.
  • the herbs are selected and cultivated in the red soil using bio-fertilizer manure or all natural waste. These are harvested in Non-sunlight after the maturity period and cut after 10 or 12 days in a non-sunlight or shed with hygienic condition preferably on stone. Subsequently dried in sunlight for 1 to 2 days. Then extracts of above herbs in following percentage by weight are selected:
  • Methi Trigonella foenum graecum
  • Kalmegh (Andrographis paniculata)
  • herb extract are ground separately in a grinder with 1500 rpm to make powder form and pulverized/ blended in the specific proportion as given above in the pulverizer/blender for thorough mixing with speed of 500 rpm for 45 minutes. Then resultant mixture sieved through the nylon cloth of 150 mesh size to obtain the required particle size of the active ingredients.
  • the formulation of the present invention is available in powdered form.
  • the invention provides herbal composition for curing Diabetes which is very well used in the medicinal field and drug industries.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un procédé pour fabriquer une composition à base d'herbes, qui comprend les étapes consistant à : a. sélectionner les extraits d'herbes suivants dans le pourcentage en poids donné : 20 % en poids d'extrait de graines de jamelonier (Syzygium cumini), 14 % en poids d'extrait de graines de trigonelle (Trigonella foenum graecum), 7 % en poids d'extrait de feuilles de margousier (Melia azadirachta), 10 % en poids d'extrait de fruits d'amla (Emblica officinalis), 7 % en poids d'extrait de fleurs et de fruits de séné (Cassia auriculata), 20 % en poids d'extrait de feuilles de gymnéma (Gymnema sylvestre), 7 % en poids d'extrait de feuilles d'échinacée d'Inde (Andrographis paniculata), 5 % en poids d'extrait de feuilles de guduchi (Tinospora cardifolia), 5 % en poids d'extrait de fruits de margose (Momordica charantia), 5 % en poids d'extrait de fruits de tribule terrestre (Tribulus terrestris), les extraits d'herbes mentionnés ci-dessus étant cultivés dans une terre rouge et récoltés en l'absence de lumière du soleil après la période de maturité et coupés en l'absence de lumière du soleil dans des conditions d'hygiène le cas échéant sur de la pierre propre pour des raisons d'hygiène et séchés à la lumière du soleil avant broyage pendant un à deux jours ; b. broyer les herbes ci-dessus séparément dans un broyeur à une vitesse de 1 500 tpm ; c. pulvériser/mélanger les ingrédients dans leur proportion spécifique telle que donnée ci-dessus dans un pulvérisateur/mélangeur fonctionnant à une vitesse de 500 tpm pendant 30 à 60 minutes ; d. tamiser la poudre mélangée à travers un tamis fait de tissu de nylon de 150 mesh d'ouverture de maille.
PCT/IN2007/000215 2006-06-13 2007-05-28 Procédé de fabrication d'une composition à base d'herbes pour soigner le diabète et composition à base d'herbes obtenue à partir de ce procédé Ceased WO2008015699A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN924MU2006 2006-06-13
IN924/MUM/2006 2006-06-13

Publications (2)

Publication Number Publication Date
WO2008015699A2 true WO2008015699A2 (fr) 2008-02-07
WO2008015699A3 WO2008015699A3 (fr) 2008-09-12

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITGE20100040A1 (it) * 2010-04-22 2011-10-23 Bioway Di Patrucco Claudio Preparato erboristico ed alimentare ad azione protettiva e tonificante degli organi del sistema genito-urinario sia femminile che maschile, ed avente come effetto ulteriore il riequilibrio del colesterolo
FR2959424A1 (fr) * 2010-05-03 2011-11-04 Baudelaire Djantou Elie Procede ptc pour l'extraction par voie seche de principes actifs naturels
CN102552466A (zh) * 2011-11-29 2012-07-11 湖南今珠生物科技有限公司 一种减肥口服制剂
WO2013057379A1 (fr) * 2011-10-19 2013-04-25 Baudelaire Elie Procede ptc pour l'extraction par voie seche des principes actifs naturels
WO2015068112A3 (fr) * 2013-11-06 2015-08-13 Anil Kumar Sharma Composition à base d'herbes pour le traitement de l'hypertension et de troubles apparentés
EP4216733A4 (fr) * 2020-09-25 2025-04-23 Diabliss Consumer Products Pvt Ltd Procédé d'amélioration des propriétés organoleptiques de produits naturels et leurs produits nutraceutiques

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946151B2 (en) * 2002-11-12 2005-09-20 Ayurvedic-Life International, Llc Therapeutic compositions
AU2004315105A1 (en) * 2004-02-03 2005-08-18 Universidad Austral De Chile Composition of labdane diterpenes extracted from Andrographis paniculata, useful for the treatment of autoimmune diseases, and Alzheimer disease by activation of PPR-gamma receptors
JP2005325025A (ja) * 2004-05-12 2005-11-24 Green Kanpo Seiyaku Kk 糖尿病予防・治療組成物
US20050255180A1 (en) * 2004-05-14 2005-11-17 Gaurav Tewari Prevention of diabetes by medicinal plants & fruits
EP1807098A1 (fr) * 2004-09-13 2007-07-18 Amcod Limited Compositions a base d'herbes pour le traitement du diabete
CN100360145C (zh) * 2005-08-25 2008-01-09 吉林大学 胡芦巴提取物及其制备方法和应用

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITGE20100040A1 (it) * 2010-04-22 2011-10-23 Bioway Di Patrucco Claudio Preparato erboristico ed alimentare ad azione protettiva e tonificante degli organi del sistema genito-urinario sia femminile che maschile, ed avente come effetto ulteriore il riequilibrio del colesterolo
FR2959424A1 (fr) * 2010-05-03 2011-11-04 Baudelaire Djantou Elie Procede ptc pour l'extraction par voie seche de principes actifs naturels
WO2013057379A1 (fr) * 2011-10-19 2013-04-25 Baudelaire Elie Procede ptc pour l'extraction par voie seche des principes actifs naturels
CN102552466A (zh) * 2011-11-29 2012-07-11 湖南今珠生物科技有限公司 一种减肥口服制剂
WO2015068112A3 (fr) * 2013-11-06 2015-08-13 Anil Kumar Sharma Composition à base d'herbes pour le traitement de l'hypertension et de troubles apparentés
EP4216733A4 (fr) * 2020-09-25 2025-04-23 Diabliss Consumer Products Pvt Ltd Procédé d'amélioration des propriétés organoleptiques de produits naturels et leurs produits nutraceutiques

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