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WO2008009924A3 - Indoles useful in the treatment of inflammation - Google Patents

Indoles useful in the treatment of inflammation Download PDF

Info

Publication number
WO2008009924A3
WO2008009924A3 PCT/GB2007/002704 GB2007002704W WO2008009924A3 WO 2008009924 A3 WO2008009924 A3 WO 2008009924A3 GB 2007002704 W GB2007002704 W GB 2007002704W WO 2008009924 A3 WO2008009924 A3 WO 2008009924A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
inflammation
useful
indoles useful
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/002704
Other languages
French (fr)
Other versions
WO2008009924A2 (en
Inventor
Benjamin Pelcman
Kristofer Olofsson
Martins Katkevics
Vita Ozola
Edgars Suna
Ivars Kalvins
Pavels Arsenjans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Biolipox AB
Original Assignee
Boehringer Ingelheim International GmbH
Biolipox AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Biolipox AB filed Critical Boehringer Ingelheim International GmbH
Publication of WO2008009924A2 publication Critical patent/WO2008009924A2/en
Publication of WO2008009924A3 publication Critical patent/WO2008009924A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

There is provided compounds of formula (I): wherein X1, R1, R2, R3, R4, R5, T and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.
PCT/GB2007/002704 2006-07-18 2007-07-18 Indoles useful in the treatment of inflammation Ceased WO2008009924A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83145006P 2006-07-18 2006-07-18
US60/831,450 2006-07-18

Publications (2)

Publication Number Publication Date
WO2008009924A2 WO2008009924A2 (en) 2008-01-24
WO2008009924A3 true WO2008009924A3 (en) 2008-03-27

Family

ID=38699134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002704 Ceased WO2008009924A2 (en) 2006-07-18 2007-07-18 Indoles useful in the treatment of inflammation

Country Status (1)

Country Link
WO (1) WO2008009924A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32138A (en) 2008-09-25 2010-04-30 Boehringer Ingelheim Int SUBSTITUTED AMIDES 2- (2,6-DICLORO-PHENYLAMINE) -6-FLUORO-1-METHYL-1H-BENCIMIDAZOL-5-CARBOXYL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
UY32470A (en) * 2009-03-05 2010-10-29 Boehringer Ingelheim Int DERIVATIVES OF 2- {2-CHLORINE-5 - [(REPLACED) METHYL] PHENYLAMINE} -1-METHYL] PHENYLAMINE} -1-METHYLBENCIMIDAZOL-5-CARBOXAMIDES-N- (SUBSTITUTED) AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS, COMPOSITIONS AND APPLIANCE
WO2010149685A1 (en) 2009-06-24 2010-12-29 Boehringer Ingelheim International Gmbh New compounds, pharmaceutical composition and methods relating thereto
EA201200046A1 (en) 2009-06-24 2012-08-30 Бёрингер Ингельхайм Интернациональ Гмбх NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND RELATED METHODS
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8759537B2 (en) * 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
US8674113B2 (en) 2010-12-10 2014-03-18 Boehringer Ingelheim International Gmbh Compounds
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
WO2016109559A2 (en) 2014-12-29 2016-07-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043672A1 (en) * 1998-02-25 1999-09-02 Genetics Institute, Inc. Inhibitors of phospholipase a2
US6630496B1 (en) * 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
WO2005123673A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006077364A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006077367A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflamation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630496B1 (en) * 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
WO1999043672A1 (en) * 1998-02-25 1999-09-02 Genetics Institute, Inc. Inhibitors of phospholipase a2
WO2005123673A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006077364A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006077367A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflamation

Also Published As

Publication number Publication date
WO2008009924A2 (en) 2008-01-24

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