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WO2008006819A3 - Use of ppar-alpha agonists to treat skeletal muscle wasting disorders - Google Patents

Use of ppar-alpha agonists to treat skeletal muscle wasting disorders Download PDF

Info

Publication number
WO2008006819A3
WO2008006819A3 PCT/EP2007/057014 EP2007057014W WO2008006819A3 WO 2008006819 A3 WO2008006819 A3 WO 2008006819A3 EP 2007057014 W EP2007057014 W EP 2007057014W WO 2008006819 A3 WO2008006819 A3 WO 2008006819A3
Authority
WO
WIPO (PCT)
Prior art keywords
skeletal muscle
ppar
alpha agonists
muscle wasting
wasting disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/057014
Other languages
French (fr)
Other versions
WO2008006819A2 (en
Inventor
Peter Carmeliet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Life Sciences Research Partners vzw
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Life Sciences Research Partners vzw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Instituut voor Biotechnologie VIB, Life Sciences Research Partners vzw filed Critical Vlaams Instituut voor Biotechnologie VIB
Priority to US12/309,321 priority Critical patent/US20090234150A1/en
Priority to EP07787289A priority patent/EP2040694A2/en
Publication of WO2008006819A2 publication Critical patent/WO2008006819A2/en
Publication of WO2008006819A3 publication Critical patent/WO2008006819A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to the field of muscle pathologies, more particularly to the field of diseases where skeletal muscle damage and muscle loss occurs. The invention shows that peroxisome proliferator-activated receptor (PPAR)-alpha agonists, such as fibrates, can be used to prevent skeletal muscle degeneration, more particularly ischemic skeletal muscle degeneration.
PCT/EP2007/057014 2006-07-14 2007-07-10 Use of ppar-alpha agonists to treat skeletal muscle wasting disorders Ceased WO2008006819A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/309,321 US20090234150A1 (en) 2006-07-14 2007-07-10 Use of ppar-alpha agonists to treat skeletal muscle wasting disorders
EP07787289A EP2040694A2 (en) 2006-07-14 2007-07-10 Use of ppar-alpha agonists to treat skeletal muscle wasting disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117242.5 2006-07-14
EP06117242 2006-07-14

Publications (2)

Publication Number Publication Date
WO2008006819A2 WO2008006819A2 (en) 2008-01-17
WO2008006819A3 true WO2008006819A3 (en) 2008-03-20

Family

ID=37307079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/057014 Ceased WO2008006819A2 (en) 2006-07-14 2007-07-10 Use of ppar-alpha agonists to treat skeletal muscle wasting disorders

Country Status (3)

Country Link
US (1) US20090234150A1 (en)
EP (1) EP2040694A2 (en)
WO (1) WO2008006819A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015015509A2 (en) * 2013-08-02 2015-02-05 Council Of Scientific & Industrial Research Ulmoside-a: useful for prevention or cure of metabolic diseases
GB201821144D0 (en) * 2018-12-21 2019-02-06 Benevolentai Bio Ltd Compositions and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034077A (en) * 1996-09-23 2000-03-07 National Research Council Of Canada 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators
WO2005023305A2 (en) * 2003-09-10 2005-03-17 Inpharmatica Limited Modulating cell activity by using an agent that reduces the level of cholesterol within a cell
WO2005063712A1 (en) * 2003-12-23 2005-07-14 Myogen, Inc. 5-ht2 receptors modulators, their pharmaceuticals compositions and their use for the treatment of cardiovascular and muscle diseases
WO2005084677A1 (en) * 2004-03-01 2005-09-15 Medestea Research & Production S.P.A. Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies
US20050245435A1 (en) * 2004-04-15 2005-11-03 Proteolix, Inc. Compounds for enzyme inhibition
WO2005120483A2 (en) * 2004-06-07 2005-12-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20053517L (en) * 2005-07-18 2007-01-19 Thia Medica As Use of lipid-lowering agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034077A (en) * 1996-09-23 2000-03-07 National Research Council Of Canada 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators
WO2005023305A2 (en) * 2003-09-10 2005-03-17 Inpharmatica Limited Modulating cell activity by using an agent that reduces the level of cholesterol within a cell
WO2005063712A1 (en) * 2003-12-23 2005-07-14 Myogen, Inc. 5-ht2 receptors modulators, their pharmaceuticals compositions and their use for the treatment of cardiovascular and muscle diseases
WO2005084677A1 (en) * 2004-03-01 2005-09-15 Medestea Research & Production S.P.A. Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies
US20050245435A1 (en) * 2004-04-15 2005-11-03 Proteolix, Inc. Compounds for enzyme inhibition
WO2005120483A2 (en) * 2004-06-07 2005-12-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof

Also Published As

Publication number Publication date
WO2008006819A2 (en) 2008-01-17
EP2040694A2 (en) 2009-04-01
US20090234150A1 (en) 2009-09-17

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