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WO2008006001A3 - Genetic polymorphisms associated with scoliosis and use thereof - Google Patents

Genetic polymorphisms associated with scoliosis and use thereof Download PDF

Info

Publication number
WO2008006001A3
WO2008006001A3 PCT/US2007/072785 US2007072785W WO2008006001A3 WO 2008006001 A3 WO2008006001 A3 WO 2008006001A3 US 2007072785 W US2007072785 W US 2007072785W WO 2008006001 A3 WO2008006001 A3 WO 2008006001A3
Authority
WO
WIPO (PCT)
Prior art keywords
scoliosis
risk
polymorphisms associated
genetic polymorphisms
developing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/072785
Other languages
French (fr)
Other versions
WO2008006001A2 (en
Inventor
Lesa M Nelson
Kenneth Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axial Biotech Inc
Original Assignee
Axial Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axial Biotech Inc filed Critical Axial Biotech Inc
Publication of WO2008006001A2 publication Critical patent/WO2008006001A2/en
Priority to US12/024,495 priority Critical patent/US20090035772A1/en
Publication of WO2008006001A3 publication Critical patent/WO2008006001A3/en
Priority to US12/339,011 priority patent/US20090104620A1/en
Priority to US12/341,289 priority patent/US8123787B2/en
Anticipated expiration legal-status Critical
Priority to US13/357,800 priority patent/US8641738B1/en
Priority to US13/526,876 priority patent/US20120258884A1/en
Priority to US13/848,772 priority patent/US20130310261A1/en
Priority to US13/852,932 priority patent/US20130288913A1/en
Priority to US14/170,691 priority patent/US9370431B2/en
Priority to US15/186,914 priority patent/US9623152B2/en
Priority to US15/488,870 priority patent/US9757152B2/en
Priority to US15/700,036 priority patent/US11020147B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to novel polymorphisms associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.
PCT/US2007/072785 2004-10-28 2007-07-03 Genetic polymorphisms associated with scoliosis and use thereof Ceased WO2008006001A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US12/024,495 US20090035772A1 (en) 2007-07-03 2008-02-01 Genetic Markers Associated With Scoliosis And Uses Thereof
US12/339,011 US20090104620A1 (en) 2007-07-03 2008-12-18 Simplified Method of Determining Predisposition to Scoliosis
US12/341,289 US8123787B2 (en) 2004-10-28 2008-12-22 Method of treating scoliosis using a biological implant
US13/357,800 US8641738B1 (en) 2004-10-28 2012-01-25 Method of treating scoliosis using a biological implant
US13/526,876 US20120258884A1 (en) 2004-10-28 2012-06-19 Method of Determining Predisposition to Scoliosis
US13/848,772 US20130310261A1 (en) 2006-07-03 2013-03-22 Simplified Method of Determining Predisposition to Scoliosis
US13/852,932 US20130288913A1 (en) 2004-10-28 2013-03-28 Method of determining predisposition to scoliosis
US14/170,691 US9370431B2 (en) 2004-10-28 2014-02-03 Method of treating scoliosis using a biological implant
US15/186,914 US9623152B2 (en) 2004-10-28 2016-06-20 Method of treating scoliosis using a biological implant to scoliosis
US15/488,870 US9757152B2 (en) 2004-10-28 2017-04-17 Method of treating scoliosis using a biological implant
US15/700,036 US11020147B2 (en) 2004-10-28 2017-09-08 Method of treating scoliosis using a biological implant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80649806P 2006-07-03 2006-07-03
US60/806,498 2006-07-03
US82526006P 2006-09-11 2006-09-11
US60/825,260 2006-09-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US13/357,800 Continuation-In-Part US8641738B1 (en) 2004-10-28 2012-01-25 Method of treating scoliosis using a biological implant

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US11/259,941 Continuation-In-Part US20060155279A1 (en) 2004-10-28 2005-10-26 Apparatus and method for concave scoliosis expansion
PCT/US2007/078127 Continuation WO2008033813A1 (en) 2006-07-03 2007-09-11 Genetic markers on chromosome 7 associated with scoliosis and use thereof
US11/968,046 Continuation US20090035768A1 (en) 2004-10-28 2007-12-31 Method of Determining Predisposition to Scoliosis and Uses Thereof
US11/968,046 A-371-Of-International US20090035768A1 (en) 2004-10-28 2007-12-31 Method of Determining Predisposition to Scoliosis and Uses Thereof
US11/968,074 Continuation US20090035769A1 (en) 2004-10-28 2007-12-31 Genetic Markers Associated with Scoliosis and Uses Thereof

Publications (2)

Publication Number Publication Date
WO2008006001A2 WO2008006001A2 (en) 2008-01-10
WO2008006001A3 true WO2008006001A3 (en) 2008-05-22

Family

ID=38895454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072785 Ceased WO2008006001A2 (en) 2004-10-28 2007-07-03 Genetic polymorphisms associated with scoliosis and use thereof

Country Status (1)

Country Link
WO (1) WO2008006001A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8641738B1 (en) 2004-10-28 2014-02-04 James W. Ogilvie Method of treating scoliosis using a biological implant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COCKETT N.E. ET AL.: "Localization of the locus causing spider lamb syndrome to the distal end of ovine chromosome 6", MAMMALIAN GENOME, vol. 10, no. 1, January 1999 (1999-01-01), pages 35 - 38 *
GRUNDBERG E.: "Genetic variability in human bone phenotypes", ACTA UNIVERSITATIS UPSALIENSIS UPPSALA 2006, DIGITAL COMPREHENSIVE SUMMARIES OF UPPSALA DISSERATIONS FROM THE FACULTY OF MEDICINE, vol. 135, 26 March 2006 (2006-03-26) *
MILLER N.H. ET AL.: "Linkage analysis of genetic loci for kyphoscoliosis on chromosomes 5p13, 13q13.3 and 13q32", AMERICAN JOURNAL OF MEDICAL GENETICS PART A, vol. 140A, no. 10, 4 April 2006 (2006-04-04), pages 1059 - 1068 *
SHARIPOV R.N. ET AL.: "Polymorphism of the aggrecan gene in families with idiopathic scoliosis", MOLECULAR BIOLOGY, vol. 40, no. 3, March 2006 (2006-03-01), pages 493 - 495, XP019403388, DOI: doi:10.1134/S0026893306030174 *

Also Published As

Publication number Publication date
WO2008006001A2 (en) 2008-01-10

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