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WO2008091161A1 - Cosmetic composition containing spermine and emu oil - Google Patents

Cosmetic composition containing spermine and emu oil Download PDF

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Publication number
WO2008091161A1
WO2008091161A1 PCT/NO2008/000026 NO2008000026W WO2008091161A1 WO 2008091161 A1 WO2008091161 A1 WO 2008091161A1 NO 2008000026 W NO2008000026 W NO 2008000026W WO 2008091161 A1 WO2008091161 A1 WO 2008091161A1
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WO
WIPO (PCT)
Prior art keywords
skin
agents
emu oil
oil
spermine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NO2008/000026
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French (fr)
Inventor
Fridtjof Bjerke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2008091161A1 publication Critical patent/WO2008091161A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • Cosmetic composition containing spermine and emu oil
  • the present invention concerns a product for application on the skin. More specific it concerns a product comprising emu oil and spermine and optionally other additive substances, for instance Aloe Vera.
  • the product may also contain other compounds like vitamins, additives, preservatives, pigments, buffers, fragrances, thickening agents, gel forming agents and neutralizing agents.
  • the product may further contain substances that makes it comfortable and suitable for application on the skin.
  • the skin product according to the invention is preferably in form of a cream or an ointment, and can be applied on the entire body, but the usual will be on the face and hands.
  • the skin product is gentle to the skin and does not contain any substances that can cause allergic reactions or local irritations.
  • compositions and agents containing emu oil in combination with other compounds are described for instance Aloe Vera, optionally together with other additives:
  • US 5 958 384 describes the use of emu oil in the treatment of skin wrinkles and to stimulate hair growth.
  • US 6 579 543 describes a composition with several components for topic application on the skin.
  • the composition has effect on analgesic, anti-inflammatory and blood circulation promotion activity.
  • US 6 951 658 describes a process for the treatment of Alzheimer's disease, dementia and depression with an agent containing emu oil, amino acids and vitamins.
  • EP 08752444 describes cosmetic compositions comprising inter alia an oil, and a composition with a particular micro structure.
  • US 20020094343 is directed to a liquid composition for topic application on the skin.
  • the composition comprises i.a. emu oil and aloe vera, and is sprayed or applied on the skin in relief of pain.
  • US 6 416 772 describes a liquid dermal agent comprising an alcohol, glycerin and emu oil for application on the skin to relief of pain.
  • Emu oil is an oil that has enhanced beneficial effects on the human skin. Its penetration capacity makes the skin smooth and flexible, and counteracts formation of cracks.
  • the oil may also be used in bath water, and can be applied to the body and feet by direct application in one or more thin layers.
  • Emu oil may also treat sun burns and burns from other heat sources, skin abrasions, mosquito bites or similar irritations.
  • the oil alleviates the symptoms and aids the skin to more rapid normalization.
  • emu oil has a slight disinfecting effect.
  • Emu oil may also be used in the treatment of animals.
  • the oil may for instance be applied on the paws of the dog.
  • the oil will retain the softness of the paws, and will avoid bursts and cracks.
  • emu oil may increase the growth of skin cells with more than 20 %.
  • Emu oil is prepared from the ostrich like Emu bird which is only found in the wild in Australia.
  • the fat of the Emu bird will protect the bird against the extreme temperatures that occurs in the nature.
  • Dermatological investigations have shown that close to 70 % of the fatty acids in emu are unsaturated, and nearly the half thereof are mono- unsaturated.
  • Oleic acid is the most abundant fatty acid, together with other fatty acids that are essential for the human health.
  • the emu oil has a wide range of beneficial characteristics:
  • Emu oil combats inflammations in muscles and joints, reduces pain, swelling and stiffness of joints.
  • Emu oil inhibits the growth of bacteria, and therefore has long storage life. Due to the low content of polyunsaturated fat, which normally is most exposed to oxidation, the emu oil does not turn rancid so quickly.
  • Emu oil does not irritate the skin during application, and additionally has few other side effects.
  • Emu oil is a superior moisture transmitter and brings the protecting characteristics into the skin, which again provides an anti-ageing effect to the skin. It is assumed that the unique combination of saturated and unsaturated fatty acids, is an explanation of the ability to increase the capability of the skin to retain water and avoid dehydration. This will increase the thickness of the skin and in that way reduce the tendency to wrinkles and formation of wrinkles in the skin. Experiments have shown that the thickness of the skin may increase with more than 10 % by using of emu oil.
  • Emu oil has demonstrated superior advantages on ageing, tired, injured and burned skin. Animal experiments have revealed favorable effects on DNA synthesis. Additionally by the use of emu oil growth of hair has been demonstrated, as the sacks of hair being in dormant condition, are being wakened and stimulate the production of new hair.
  • Polyamines are organic compounds with two or more primary amino groups, and examples of polyamines are putrescine, spermidine and spermine.
  • spermine is naturally abundant in all cells of the body, but the amounts thereof vary strongly in different types of cells.
  • One of the most important features of spermine is the strong anti-oxidant effect.
  • spermine in the cells is transformed from the related compound spermidine.
  • the anti- oxidative effects of spermine have shown superior results concerning diminishing of wrinkles in the skin, improvement of the elasticity of the skin, pigmentation, skin colour and flexibility.
  • Aloe Vera is a widely used product within the cosmetic and skin care areas, especially for the application and treatment of the human skin.
  • the species of plant from which the Aloe Vera is extracted, has since ancient history been known as a cosmetic beauty preparation and medicinal plant with alleviating effects.
  • Aloe Vera may relieve and reduce infections and inflammations and provide favorable effects on eczema, dry, chapped and tired skin. Aloe Vera has therefore a wide utilization in a number of cosmetic products as body lotion, cleansing cream, soap, sun cream, shampoo and ointment. It has also been used in the treatment of fungus infections.
  • the skin is one of the body's most important organs, and has a thickness of 2 - 3 mm.
  • the skin of an adult covers a total area of 1,5 to 2 m 2 , and constitutes about 15 % of the body weight.
  • the skin is a complex organ consisting of many different components and cells with different and important functions.
  • An average cm 2 of the skin may inter alia consist of about 300 sweat glands, 10 blood vessels, 30 000 melanocytes and 1000 nerve endings.
  • the skin is in addition rich in lipids, DNA and proteins.
  • the skin is usually divided into three main layers, namely epidermis which is the outermost, then follows the dermis, and innermost the hypodermis.
  • epidermis which is the outermost, then follows the dermis, and innermost the hypodermis.
  • the skin has many important functions, and the most important is to protect the body against attacks from the surrounding environment, of pathogens and infections.
  • the skin also protects the underlying cells and tissue, muscles and internal organs.
  • the skin also provides insulation and regulation of temperature, body feeling and the synthesis of vitamins like B and D. Furthermore the skin contains pigmentation and melanocytes that absorb the potentially hazardous ultra violet solar radiation rays.
  • the skin contains enzymes that assist in, repair and reverse injuries from ultra violet radiation, injuries that if not repaired, may during time develop into skin cancer. Injured skin will try to heal with the formation of tissue, and the injury may give rise to visible scar and discoloration of the skin area.
  • the present invention is in contrast to the above referenced patents, directed to a product wherein the main components are spermine and emu oil. It has been shown that a combination of these components have a surprisingly good impact on the human skin. As mentioned both spermine and emu oil have separately good effects on skin, and in a combination of the compounds of the invention, the effects are further strengthened. None of the above referenced patents describe a combination of spermine and emu oil.
  • the product or compositions according to the invention are in the form of a cream, ointment or oil to be applied on the skin for the treatment of skin conditions like wrinkles, burns, sunburns, ageing, tired and stressed skin, and is characterized by that it contains a mixture of spermine, emu oil and optionally Aloe Vera.
  • the different ingredients may be present in quantities from 0 to 100 % by weight.
  • composition according to the invention is prepared by mixing the components in suitable quantities and all is mixed until a homogen mixture has been attained. Additionally the composition may contain one or more of additives chosen among the group of preservatives, buffers, pigments, fragrances, stabilizing agents gel forming agents, preserving agents, oils, antibiotic agents, vitamins, water, thickening and neutralizing agents.
  • additives chosen among the group of preservatives, buffers, pigments, fragrances, stabilizing agents gel forming agents, preserving agents, oils, antibiotic agents, vitamins, water, thickening and neutralizing agents.
  • thickening agents that may be used in the invention are poly acrylate based compositions.
  • Neutralizing agents that may be used are for example tri-ethanol amine, and as anti-micro biological preservatives propyl parabene may be used.
  • the above mentioned additive agents are mentioned as examples only, and the invention is not restricted to these. Compounds known in the art may be used.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composition in form of a cream, liniment or oil for application on the skin for treatment of skin conditions such as wrinkles, burns, sunburns, aging, tired and stressed skin, and distinguished by the inclusion of a mixture of spermine, emu oil and possibly aloe vera. The composition may additionally contain one or more of the additives chosen among the group of preservatives, buffers, pigments, fragrances, stabilizing agents, gel forming agents, preservatives, oils, antibiotic agents, vitamins, water, thickening and neutralising ingredients.

Description

Cosmetic composition containing spermine and emu oil
The present invention concerns a product for application on the skin. More specific it concerns a product comprising emu oil and spermine and optionally other additive substances, for instance Aloe Vera. The product may also contain other compounds like vitamins, additives, preservatives, pigments, buffers, fragrances, thickening agents, gel forming agents and neutralizing agents. In addition the product may further contain substances that makes it comfortable and suitable for application on the skin.
The skin product according to the invention is preferably in form of a cream or an ointment, and can be applied on the entire body, but the usual will be on the face and hands.
The skin product is gentle to the skin and does not contain any substances that can cause allergic reactions or local irritations.
Several compositions and agents containing emu oil in combination with other compounds are described for instance Aloe Vera, optionally together with other additives:
US 5 958 384 describes the use of emu oil in the treatment of skin wrinkles and to stimulate hair growth.
US 6 579 543 describes a composition with several components for topic application on the skin. The composition has effect on analgesic, anti-inflammatory and blood circulation promotion activity.
US 6 951 658 describes a process for the treatment of Alzheimer's disease, dementia and depression with an agent containing emu oil, amino acids and vitamins.
EP 08752444 describes cosmetic compositions comprising inter alia an oil, and a composition with a particular micro structure. US 20020094343 is directed to a liquid composition for topic application on the skin. The composition comprises i.a. emu oil and aloe vera, and is sprayed or applied on the skin in relief of pain.
US 6 416 772 describes a liquid dermal agent comprising an alcohol, glycerin and emu oil for application on the skin to relief of pain.
Emu oil
Emu oil is an oil that has enhanced beneficial effects on the human skin. Its penetration capacity makes the skin smooth and flexible, and counteracts formation of cracks. The oil may also be used in bath water, and can be applied to the body and feet by direct application in one or more thin layers.
Emu oil may also treat sun burns and burns from other heat sources, skin abrasions, mosquito bites or similar irritations. The oil alleviates the symptoms and aids the skin to more rapid normalization. In addition emu oil has a slight disinfecting effect.
Emu oil may also be used in the treatment of animals. The oil may for instance be applied on the paws of the dog. The oil will retain the softness of the paws, and will avoid bursts and cracks.
In thousands of years the native population of Australia, the Aborigines have used emu oil, and the oil is today approved by the Australian authorities as a pharmaceutical product.
Newer research and investigations have revealed that emu oil may increase the growth of skin cells with more than 20 %.
Emu oil is prepared from the ostrich like Emu bird which is only found in the wild in Australia. The fat of the Emu bird will protect the bird against the extreme temperatures that occurs in the nature. Dermatological investigations have shown that close to 70 % of the fatty acids in emu are unsaturated, and nearly the half thereof are mono- unsaturated. Oleic acid is the most abundant fatty acid, together with other fatty acids that are essential for the human health. The emu oil has a wide range of beneficial characteristics:
- The most important characteristic is the capability of the oil to permeate (enter through) the human skin. - Emu oil combats inflammations in muscles and joints, reduces pain, swelling and stiffness of joints.
- It is a good emulsifying agent, and demonstrate good mixing ability with other oils, and for instance water.
- Emu oil inhibits the growth of bacteria, and therefore has long storage life. Due to the low content of polyunsaturated fat, which normally is most exposed to oxidation, the emu oil does not turn rancid so quickly.
- Emu oil does not irritate the skin during application, and additionally has few other side effects.
- During application it does not clog the pores of the skin, and does not cause impure skin or formation of acne .
Emu oil is a superior moisture transmitter and brings the protecting characteristics into the skin, which again provides an anti-ageing effect to the skin. It is assumed that the unique combination of saturated and unsaturated fatty acids, is an explanation of the ability to increase the capability of the skin to retain water and avoid dehydration. This will increase the thickness of the skin and in that way reduce the tendency to wrinkles and formation of wrinkles in the skin. Experiments have shown that the thickness of the skin may increase with more than 10 % by using of emu oil.
Emu oil has demonstrated superior advantages on ageing, tired, injured and burned skin. Animal experiments have revealed favorable effects on DNA synthesis. Additionally by the use of emu oil growth of hair has been demonstrated, as the sacks of hair being in dormant condition, are being wakened and stimulate the production of new hair. Spermine
Spermines belong to the group of polyamines and are naturally occurring as growth factors and regulation in eukaryotic cells in many organisms. Polyamines are organic compounds with two or more primary amino groups, and examples of polyamines are putrescine, spermidine and spermine.
Spermine is naturally abundant in all cells of the body, but the amounts thereof vary strongly in different types of cells. One of the most important features of spermine is the strong anti-oxidant effect.
Spermine in the cells is transformed from the related compound spermidine. The anti- oxidative effects of spermine have shown superior results concerning diminishing of wrinkles in the skin, improvement of the elasticity of the skin, pigmentation, skin colour and flexibility.
Aloe Vera
Aloe Vera is a widely used product within the cosmetic and skin care areas, especially for the application and treatment of the human skin. The species of plant from which the Aloe Vera is extracted, has since ancient history been known as a cosmetic beauty preparation and medicinal plant with alleviating effects.
Further it is known that Aloe Vera may relieve and reduce infections and inflammations and provide favorable effects on eczema, dry, chapped and tired skin. Aloe Vera has therefore a wide utilization in a number of cosmetic products as body lotion, cleansing cream, soap, sun cream, shampoo and ointment. It has also been used in the treatment of fungus infections.
Many of the advantageous effects of Aloe Vera are inter alia a result of its content of muco-polysaccarides.
The skin
The skin is one of the body's most important organs, and has a thickness of 2 - 3 mm. The skin of an adult covers a total area of 1,5 to 2 m2, and constitutes about 15 % of the body weight. The skin is a complex organ consisting of many different components and cells with different and important functions. An average cm2 of the skin may inter alia consist of about 300 sweat glands, 10 blood vessels, 30 000 melanocytes and 1000 nerve endings. The skin is in addition rich in lipids, DNA and proteins.
The skin is usually divided into three main layers, namely epidermis which is the outermost, then follows the dermis, and innermost the hypodermis. The skin has many important functions, and the most important is to protect the body against attacks from the surrounding environment, of pathogens and infections. The skin also protects the underlying cells and tissue, muscles and internal organs.
The skin also provides insulation and regulation of temperature, body feeling and the synthesis of vitamins like B and D. Furthermore the skin contains pigmentation and melanocytes that absorb the potentially hazardous ultra violet solar radiation rays. The skin contains enzymes that assist in, repair and reverse injuries from ultra violet radiation, injuries that if not repaired, may during time develop into skin cancer. Injured skin will try to heal with the formation of tissue, and the injury may give rise to visible scar and discoloration of the skin area.
The present invention is in contrast to the above referenced patents, directed to a product wherein the main components are spermine and emu oil. It has been shown that a combination of these components have a surprisingly good impact on the human skin. As mentioned both spermine and emu oil have separately good effects on skin, and in a combination of the compounds of the invention, the effects are further strengthened. None of the above referenced patents describe a combination of spermine and emu oil.
The product or compositions according to the invention are in the form of a cream, ointment or oil to be applied on the skin for the treatment of skin conditions like wrinkles, burns, sunburns, ageing, tired and stressed skin, and is characterized by that it contains a mixture of spermine, emu oil and optionally Aloe Vera. The different ingredients may be present in quantities from 0 to 100 % by weight.
The composition according to the invention is prepared by mixing the components in suitable quantities and all is mixed until a homogen mixture has been attained. Additionally the composition may contain one or more of additives chosen among the group of preservatives, buffers, pigments, fragrances, stabilizing agents gel forming agents, preserving agents, oils, antibiotic agents, vitamins, water, thickening and neutralizing agents.
An example of thickening agents that may be used in the invention are poly acrylate based compositions. Neutralizing agents that may be used are for example tri-ethanol amine, and as anti-micro biological preservatives propyl parabene may be used. The above mentioned additive agents are mentioned as examples only, and the invention is not restricted to these. Compounds known in the art may be used.
An important prerequisite to use additive agents in the compositions, is that they will not provoke allergic or irritating reactions by the user.

Claims

CLAIMS 1.
Composition for application on the skin for the treatment of skin conditions as wrinkles, bums, sun burn, ageing, tired and stressed skin, c h a r a c t e r i s e d b y t h a t it comprises a mixture of spermine, emu oil and optionally Aloe Vera.
2.
Composition according to claim 1, c h a r a c t e r i s e d b y t h a t it comprises spermine in an amount from 0 to 100 % by weight, emu oil in an amount from 0 to 100 % by weight, and Aloe Vera in an amount from 0 to 100 % by weight.
3.
Composition according to claims 1 or 2, c h a r a c t e r i s e d b y t h a t it additionally comprises further additive agents.
4.
Composition according to any of the preceding claims, c h a r a c t e r i s e d b y t h a t it may contain one or more of the additives chosen among the group of preservatives, buffers, pigments, fragrances, stabilizing agents, gel forming agents, preserving agents, oils, antibiotic agents, vitamins, water, thickening and neutralizing agents.
5.
Composition according to any of the preceding claims, c h a r a c t e r i s e d b y t h a t one or more of the chosen additives may be present in an amount from 0 to 100 % by weight.
6. Composition according to any of the preceding claims, c h a r a c t e r i s e d b y t h a t it is in form of a cream, an ointment, oil or a pill.
PCT/NO2008/000026 2007-01-26 2008-01-25 Cosmetic composition containing spermine and emu oil Ceased WO2008091161A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20070534 2007-01-26
NO20070534 2007-01-26

Publications (1)

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WO2008091161A1 true WO2008091161A1 (en) 2008-07-31

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009020398A3 (en) * 2007-08-06 2009-04-02 Spero As Skin care product
RU2397750C1 (en) * 2009-05-12 2010-08-27 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУВПО "КубГТУ") Cosmetic cream for hands, face and body
JP2016138082A (en) * 2015-01-26 2016-08-04 小川　和宏 Anti-fatigue drug and anti-fatigue food
CN108498419A (en) * 2018-05-03 2018-09-07 天津炫盛科技开发有限公司 Spot-removing ointment and preparation method thereof
DE202022001251U1 (en) 2022-05-11 2022-07-19 Pharmachem Pößneck GmbH & Co. KG Pharmaceutical skin care product

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
WO1996023490A1 (en) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations and methods for reducing skin irritation
WO1996034596A2 (en) * 1995-05-03 1996-11-07 Holick, Michael, F. Use of emu oil for stimulating skin and hair growth
WO2002024185A2 (en) * 2000-09-19 2002-03-28 Dermal Therapy (Barbados) Inc. Topical analgesic compositions containing aliphatic polyamines and methods of using same
US6528040B1 (en) * 2001-01-18 2003-03-04 Maurine Pearson EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic
WO2005013932A1 (en) * 2003-07-31 2005-02-17 Giuliani S.P.A. Use of spermine and/or spermidine against skin ageting in dietary, pharmaceutical or cosmetic compositions
US6949262B1 (en) * 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
WO2006048671A1 (en) * 2004-11-05 2006-05-11 Bioforskning As Polyamine compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
WO1996023490A1 (en) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations and methods for reducing skin irritation
WO1996034596A2 (en) * 1995-05-03 1996-11-07 Holick, Michael, F. Use of emu oil for stimulating skin and hair growth
WO2002024185A2 (en) * 2000-09-19 2002-03-28 Dermal Therapy (Barbados) Inc. Topical analgesic compositions containing aliphatic polyamines and methods of using same
US6528040B1 (en) * 2001-01-18 2003-03-04 Maurine Pearson EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic
US6949262B1 (en) * 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
WO2005013932A1 (en) * 2003-07-31 2005-02-17 Giuliani S.P.A. Use of spermine and/or spermidine against skin ageting in dietary, pharmaceutical or cosmetic compositions
WO2006048671A1 (en) * 2004-11-05 2006-05-11 Bioforskning As Polyamine compositions

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009020398A3 (en) * 2007-08-06 2009-04-02 Spero As Skin care product
RU2397750C1 (en) * 2009-05-12 2010-08-27 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУВПО "КубГТУ") Cosmetic cream for hands, face and body
JP2016138082A (en) * 2015-01-26 2016-08-04 小川　和宏 Anti-fatigue drug and anti-fatigue food
CN108498419A (en) * 2018-05-03 2018-09-07 天津炫盛科技开发有限公司 Spot-removing ointment and preparation method thereof
DE202022001251U1 (en) 2022-05-11 2022-07-19 Pharmachem Pößneck GmbH & Co. KG Pharmaceutical skin care product

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