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WO2008089003A3 - System for optical stimulation of target cells - Google Patents

System for optical stimulation of target cells Download PDF

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Publication number
WO2008089003A3
WO2008089003A3 PCT/US2008/050628 US2008050628W WO2008089003A3 WO 2008089003 A3 WO2008089003 A3 WO 2008089003A3 US 2008050628 W US2008050628 W US 2008050628W WO 2008089003 A3 WO2008089003 A3 WO 2008089003A3
Authority
WO
WIPO (PCT)
Prior art keywords
target cells
light
methods
vivo
stimulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/050628
Other languages
French (fr)
Other versions
WO2008089003A2 (en
Inventor
Feng Zhang
Karl Deisseroth
David J Mishelevich
M Bret Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/651,422 external-priority patent/US8926959B2/en
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to US12/522,528 priority Critical patent/US10052497B2/en
Publication of WO2008089003A2 publication Critical patent/WO2008089003A2/en
Publication of WO2008089003A3 publication Critical patent/WO2008089003A3/en
Anticipated expiration legal-status Critical
Priority to US16/041,647 priority patent/US20180326221A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
PCT/US2008/050628 2005-07-22 2008-01-09 System for optical stimulation of target cells Ceased WO2008089003A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/522,528 US10052497B2 (en) 2005-07-22 2008-01-09 System for optical stimulation of target cells
US16/041,647 US20180326221A1 (en) 2005-07-22 2018-07-20 System for optical stimulation of target cells

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11/651,422 US8926959B2 (en) 2005-07-22 2007-01-09 System for optical stimulation of target cells
US11/651,422 2007-01-09
US87966907P 2007-01-10 2007-01-10
US60/879,669 2007-01-10
US90430307P 2007-03-01 2007-03-01
US60/904,303 2007-03-01
US95511607P 2007-08-10 2007-08-10
US60/955,116 2007-08-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/651,422 Continuation US8926959B2 (en) 2005-07-22 2007-01-09 System for optical stimulation of target cells

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/522,528 A-371-Of-International US10052497B2 (en) 2005-07-22 2008-01-09 System for optical stimulation of target cells
US16/041,647 Continuation US20180326221A1 (en) 2005-07-22 2018-07-20 System for optical stimulation of target cells

Publications (2)

Publication Number Publication Date
WO2008089003A2 WO2008089003A2 (en) 2008-07-24
WO2008089003A3 true WO2008089003A3 (en) 2008-09-25

Family

ID=39636625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/050628 Ceased WO2008089003A2 (en) 2005-07-22 2008-01-09 System for optical stimulation of target cells

Country Status (1)

Country Link
WO (1) WO2008089003A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8591419B2 (en) 2008-07-14 2013-11-26 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US9042201B2 (en) 2011-10-21 2015-05-26 Thync, Inc. Method and system for direct communication
US10413757B2 (en) 2012-08-29 2019-09-17 Cerevast Medical, Inc. Systems and devices for coupling ultrasound energy to a body
CN107531765B (en) * 2015-03-19 2021-07-16 得克萨斯州大学系统董事会 Compositions of anion channelrhodopsin and methods of use
US11771763B2 (en) 2010-04-05 2023-10-03 Eos Neuroscience, Inc. Methods and compositions for decreasing chronic pain
US12097268B2 (en) 2010-10-15 2024-09-24 Eos Neuroscience, Inc. Modulation of neural pathways

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102159713A (en) 2008-05-20 2011-08-17 Eos神经科学公司 Vectors for delivery of light-sensitive proteins and methods of use
WO2010062978A2 (en) 2008-11-26 2010-06-03 Medtronic, Inc. Automated verification of mri compatibility of active implantable medical device
CN101498723A (en) * 2009-02-27 2009-08-05 深圳先进技术研究院 Ion channel medicament screening apparatus and method
DE102009061008B4 (en) * 2009-03-20 2014-09-25 Retina Implant Ag Use of a test device and method for testing cells, cell cultures and / or organotypic cell aggregates
WO2010105728A2 (en) * 2009-03-20 2010-09-23 Retina Implant Ag Active retinal implant
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
US20120253261A1 (en) * 2011-03-29 2012-10-04 Medtronic, Inc. Systems and methods for optogenetic modulation of cells within a patient
EP2736406B1 (en) 2011-07-25 2019-09-04 NeuroNexus Technologies, Inc. Neuromodulation transfection system with means for active fluid delivery
US10493297B2 (en) 2011-07-25 2019-12-03 Neuronexus Technologies, Inc. Neuromodulation transfection system with passive fluid delivery
EP2736402B1 (en) 2011-07-25 2018-01-10 NeuroNexus Technologies, Inc. Opto-electrical device and method for artifact reduction
US9199080B2 (en) 2011-09-12 2015-12-01 Okuvision Gmbh Method for treating an eye
US8868351B2 (en) 2011-10-13 2014-10-21 The Cleveland Clinic Foundation Estimation of neural response for optical stimulation
CN111103272B (en) * 2018-10-26 2022-08-05 山东大学 Real-time screening and measuring system and method for cell specific photosensitive effect
CN111690683A (en) * 2020-05-08 2020-09-22 天津大学 Design method of photosensitive protein plasmid sensitive to green light

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BROSENITCH ET AL.: "Physiological Patterns of Electrical Stimulation Can Induce Neuronal Gene Expressing by Activating N-Type Calcium Channels", J. OF NEUROSCIENCE, vol. 21, 2001, pages 2571 - 2579 *
SONG ET AL.: "Genes responsible for native depolarization-activated K+ currents in neurons", NEUROSCIENCE RES., vol. 42, 2002, pages 7 - 14 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8591419B2 (en) 2008-07-14 2013-11-26 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US8858440B2 (en) 2008-07-14 2014-10-14 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US9403038B2 (en) 2008-07-14 2016-08-02 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US10556132B2 (en) 2008-07-14 2020-02-11 Arizona Board Of Regents On Behalf Of Arizona State University Methods and devices for modulating cellular activity using ultrasound
US11771763B2 (en) 2010-04-05 2023-10-03 Eos Neuroscience, Inc. Methods and compositions for decreasing chronic pain
US12097268B2 (en) 2010-10-15 2024-09-24 Eos Neuroscience, Inc. Modulation of neural pathways
US9042201B2 (en) 2011-10-21 2015-05-26 Thync, Inc. Method and system for direct communication
US9729252B2 (en) 2011-10-21 2017-08-08 Cerevast Medical, Inc. Method and system for direct communication
US10413757B2 (en) 2012-08-29 2019-09-17 Cerevast Medical, Inc. Systems and devices for coupling ultrasound energy to a body
CN107531765B (en) * 2015-03-19 2021-07-16 得克萨斯州大学系统董事会 Compositions of anion channelrhodopsin and methods of use

Also Published As

Publication number Publication date
WO2008089003A2 (en) 2008-07-24

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