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WO2008080629A3 - Verbesserte molekularbiologische prozessanlage - Google Patents

Verbesserte molekularbiologische prozessanlage Download PDF

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Publication number
WO2008080629A3
WO2008080629A3 PCT/EP2007/011478 EP2007011478W WO2008080629A3 WO 2008080629 A3 WO2008080629 A3 WO 2008080629A3 EP 2007011478 W EP2007011478 W EP 2007011478W WO 2008080629 A3 WO2008080629 A3 WO 2008080629A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
processing system
molecular biological
biological processing
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/011478
Other languages
English (en)
French (fr)
Other versions
WO2008080629A2 (de
Inventor
Peer Staehler
Markus Beier
Cord Staehler
Daniel Summerer
Mark Matzas
Sonja Vorwerk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Febit Holding GmbH
Original Assignee
Febit Holding GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102006062089A external-priority patent/DE102006062089A1/de
Priority claimed from DE102007018833A external-priority patent/DE102007018833A1/de
Application filed by Febit Holding GmbH filed Critical Febit Holding GmbH
Priority to US12/521,765 priority Critical patent/US20110092380A1/en
Priority to EP07857168A priority patent/EP2109499A2/de
Publication of WO2008080629A2 publication Critical patent/WO2008080629A2/de
Publication of WO2008080629A3 publication Critical patent/WO2008080629A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00439—Maskless processes using micromirror arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00448—Maskless processes using microlens arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00497—Features relating to the solid phase supports
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    • B01J2219/00572—Chemical means
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00675—In-situ synthesis on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
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    • B01J2219/00718—Type of compounds synthesised
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die Erfindung bezieht sich auf eine verbesserte molekularbiologische Prozessanlage sowie ein verbessertes Verfahren zur Prozessierung biologischer Proben. Die Erfindung kombiniert die Bereitstellung biologisch funktionaler Moleküle wie Nukleinsäuren und Peptide sowie von Derivaten oder Analoga dieser beiden Molekülklassen in miniaturisierten Flusszellen mit der seriellen Zugabe von Reagenzien oder Fluiden und dient der Bearbeitung von biologischen Proben, wie Proteinen, Nukleinsäuren, biogener kleiner Moleküle wie z.B. Metaboliten, Viren oder Zellen, die dazu in die miniaturisierten Flusszellen eingebracht werden. Die Erfindung bezieht sich weiterhin auf Verfahren und auf die Verwendung der erfindungsgemäßen molekularbiologischen Prozessanlage zum Nachweis oder/und zur Isolierung von Nukleinsäuren; zur Sequenzierung; zur Punktmutationsanalyse; zur Analyse von Genomen und/oder Chromosomen; zur Herstellung synthetischer Nukleinsäuren; zur Herstellung von Arrays von Primern, Sonden und/oder Antisense-Molekülen; sowie weiterer analytischer und synthetischer Verfahren.
PCT/EP2007/011478 2006-12-29 2007-12-31 Verbesserte molekularbiologische prozessanlage Ceased WO2008080629A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/521,765 US20110092380A1 (en) 2006-12-29 2007-12-31 Improved molecular-biological processing equipment
EP07857168A EP2109499A2 (de) 2006-12-29 2007-12-31 Verbesserte molekularbiologische processanlage

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006062089.5 2006-12-29
DE102006062089A DE102006062089A1 (de) 2006-12-29 2006-12-29 Verbesserte molekularbiologische Prozessanlage
DE102007018833A DE102007018833A1 (de) 2007-04-20 2007-04-20 Verbesserte molekularbiologische Prozessanlage
DE102007018833.3 2007-04-20

Publications (2)

Publication Number Publication Date
WO2008080629A2 WO2008080629A2 (de) 2008-07-10
WO2008080629A3 true WO2008080629A3 (de) 2008-11-13

Family

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PCT/EP2007/011478 Ceased WO2008080629A2 (de) 2006-12-29 2007-12-31 Verbesserte molekularbiologische prozessanlage

Country Status (3)

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US (1) US20110092380A1 (de)
EP (1) EP2109499A2 (de)
WO (1) WO2008080629A2 (de)

Families Citing this family (12)

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DE102007056398A1 (de) * 2007-11-23 2009-05-28 Febit Holding Gmbh Flexibles Extraktionsverfahren für die Herstellung sequenzspezifischer Molekülbibliotheken
WO2010039189A2 (en) * 2008-09-23 2010-04-08 Helicos Biosciences Corporation Methods for sequencing degraded or modified nucleic acids
WO2010043418A2 (de) * 2008-10-17 2010-04-22 Febit Holding Gmbh Integrierte amplifikation, prozessierung und analyse von biomolekülen in einem mikrofluidischen reaktionsträger
DE102009029831A1 (de) 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
WO2012083258A2 (en) * 2010-12-16 2012-06-21 Sensor Innovations, Inc. Electrochemical sensors
US10407460B2 (en) * 2015-05-07 2019-09-10 The Regents Of The University Of Califonia Solid phase sequence-independent nucleic acid assembly
ES2753274T5 (es) * 2015-08-21 2023-05-26 42 Life Sciences Gmbh & Co Kg Composición y procedimiento de hibridación
WO2018217689A1 (en) 2017-05-22 2018-11-29 The Charles Stark Draper Laboratory, Inc. Modified template-independent dna polymerase
US20190009240A1 (en) * 2017-07-10 2019-01-10 The Charles Stark Draper Laboratory, Inc. Apparatus Enabling High Density Information Storage in Molecular Chains
WO2019222650A1 (en) 2018-05-17 2019-11-21 The Charles Stark Draper Laboratory, Inc. Apparatus for high density information storage in molecular chains
JP7638478B2 (ja) * 2020-07-30 2025-03-04 国立研究開発法人産業技術総合研究所 微小構造体と分子検出法
CN115561451A (zh) * 2022-10-20 2023-01-03 上海交通大学 一种基于计算机辅助设计的侧流层析检测试纸

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US6245508B1 (en) * 1993-11-01 2001-06-12 Nanogen, Inc. Method for fingerprinting utilizing an electronically addressable array
WO2003035259A2 (de) * 2001-10-22 2003-05-01 Febit Ag Arrays mit hairpin-strukturen
EP1371990A1 (de) * 2001-02-14 2003-12-17 Riken Mikrochip
US20050142664A1 (en) * 2003-12-18 2005-06-30 Affymetrix, Inc. System, method, and product for mixing fluids in a chamber

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US6245508B1 (en) * 1993-11-01 2001-06-12 Nanogen, Inc. Method for fingerprinting utilizing an electronically addressable array
WO1999040105A2 (en) * 1998-02-06 1999-08-12 Affymetrix, Inc. Array fabrication methods
EP1371990A1 (de) * 2001-02-14 2003-12-17 Riken Mikrochip
WO2003035259A2 (de) * 2001-10-22 2003-05-01 Febit Ag Arrays mit hairpin-strukturen
US20050142664A1 (en) * 2003-12-18 2005-06-30 Affymetrix, Inc. System, method, and product for mixing fluids in a chamber

Also Published As

Publication number Publication date
WO2008080629A2 (de) 2008-07-10
US20110092380A1 (en) 2011-04-21
EP2109499A2 (de) 2009-10-21

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