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WO2008077062A3 - Suppression of stat3 reactivation after src kinase inhibition to treat cancer - Google Patents

Suppression of stat3 reactivation after src kinase inhibition to treat cancer Download PDF

Info

Publication number
WO2008077062A3
WO2008077062A3 PCT/US2007/087980 US2007087980W WO2008077062A3 WO 2008077062 A3 WO2008077062 A3 WO 2008077062A3 US 2007087980 W US2007087980 W US 2007087980W WO 2008077062 A3 WO2008077062 A3 WO 2008077062A3
Authority
WO
WIPO (PCT)
Prior art keywords
stat3
inhibitor
reactivation
sfk
suppression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/087980
Other languages
French (fr)
Other versions
WO2008077062A2 (en
Inventor
Faye M Johnson
Nicholas J Donato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of WO2008077062A2 publication Critical patent/WO2008077062A2/en
Publication of WO2008077062A3 publication Critical patent/WO2008077062A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of treating cancer are disclosed that comprise administering an inhibitor of SFK in a therapeutically effective amount to the subject wherein STAT3 is durably inhibited. The methods include the administration of an SFK inhibitor in combination with a suitable inhibitor of STAT3 reactivation including a STAT3 inhibitor, a JAK inhibitor or any molecule that inhibits STAT3 reactivation or the compensatory pathway for cell survial after inhibition of the SFK. Also provided are therapeutic compositions comprising an SFK inhibitor in combination with at least one inhibitor of STAT3 reactivation.
PCT/US2007/087980 2006-12-19 2007-12-18 Suppression of stat3 reactivation after src kinase inhibition to treat cancer Ceased WO2008077062A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87068206P 2006-12-19 2006-12-19
US60/870,682 2006-12-19

Publications (2)

Publication Number Publication Date
WO2008077062A2 WO2008077062A2 (en) 2008-06-26
WO2008077062A3 true WO2008077062A3 (en) 2008-10-09

Family

ID=39537057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/087980 Ceased WO2008077062A2 (en) 2006-12-19 2007-12-18 Suppression of stat3 reactivation after src kinase inhibition to treat cancer

Country Status (1)

Country Link
WO (1) WO2008077062A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2200431B1 (en) 2007-09-10 2016-07-20 Boston Biomedical, Inc. Novel compositions and methods for cancer treatment
WO2010065444A1 (en) 2008-12-01 2010-06-10 University Of Central Florida Research Foundation, Inc. Drug composition cytotoxic for pancreatic cancer cells
SA111320200B1 (en) 2010-02-17 2014-02-16 ديبيوفارم اس ايه Bicyclic Compounds and their Uses as Dual C-SRC / JAK Inhibitors
MX2015014181A (en) 2013-04-09 2016-05-24 Boston Biomedical Inc 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer.
JP7106563B2 (en) 2016-11-29 2022-07-26 スミトモ ファーマ オンコロジー， インコーポレイテッド Naphthofuran derivatives, their preparation and methods of use
WO2018213424A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
CN113082036B (en) * 2021-03-17 2022-11-01 中国海洋大学 Dual inhibitors targeting JAK/STAT and NFκB signaling pathways and their applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAWAKAYA F.: "SFK-STAT pathway: an alternative and important way to malignancies", ANN. NY. ACAD. SCI., vol. 1086, 2006, pages 213 - 222 *

Also Published As

Publication number Publication date
WO2008077062A2 (en) 2008-06-26

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