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WO2008073979A3 - Near-infrared electromagnetic modification of cellular steady- state membrane potentials - Google Patents

Near-infrared electromagnetic modification of cellular steady- state membrane potentials Download PDF

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Publication number
WO2008073979A3
WO2008073979A3 PCT/US2007/087264 US2007087264W WO2008073979A3 WO 2008073979 A3 WO2008073979 A3 WO 2008073979A3 US 2007087264 W US2007087264 W US 2007087264W WO 2008073979 A3 WO2008073979 A3 WO 2008073979A3
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
potentials
decrease
steady
depolarization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/087264
Other languages
French (fr)
Other versions
WO2008073979A2 (en
Inventor
Eric Bornstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOMIR MEDICAL TECHNOLOGIES Inc
Original Assignee
NOMIR MEDICAL TECHNOLOGIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/981,486 external-priority patent/US20090299263A1/en
Priority claimed from US11/981,340 external-priority patent/US20080131968A1/en
Priority claimed from US11/981,431 external-priority patent/US8506979B2/en
Application filed by NOMIR MEDICAL TECHNOLOGIES Inc filed Critical NOMIR MEDICAL TECHNOLOGIES Inc
Priority to JP2009541559A priority Critical patent/JP2010512232A/en
Priority to CA002670711A priority patent/CA2670711A1/en
Priority to EP07865581A priority patent/EP2089107A2/en
Priority to AU2007333073A priority patent/AU2007333073A1/en
Publication of WO2008073979A2 publication Critical patent/WO2008073979A2/en
Publication of WO2008073979A3 publication Critical patent/WO2008073979A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laser Surgery Devices (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
PCT/US2007/087264 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cellular steady- state membrane potentials Ceased WO2008073979A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009541559A JP2010512232A (en) 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cell steady-state membrane potential.
CA002670711A CA2670711A1 (en) 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cellular steady-state membrane potentials
EP07865581A EP2089107A2 (en) 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cellular steady- state membrane potentials
AU2007333073A AU2007333073A1 (en) 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cellular steady- state membrane potentials

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US87442406P 2006-12-12 2006-12-12
US60/874,424 2006-12-12
US11/981,340 2007-10-31
US11/981,486 2007-10-31
US11/981,431 2007-10-31
US11/981,486 US20090299263A1 (en) 2002-08-28 2007-10-31 Near-Infrared electromagnetic modification of cellular steady-state membrane potentials
US11/981,340 US20080131968A1 (en) 2002-08-28 2007-10-31 Near-infrared electromagnetic modification of cellular steady-state membrane potentials
US11/981,431 US8506979B2 (en) 2002-08-28 2007-10-31 Near-infrared electromagnetic modification of cellular steady-state membrane potentials

Publications (2)

Publication Number Publication Date
WO2008073979A2 WO2008073979A2 (en) 2008-06-19
WO2008073979A3 true WO2008073979A3 (en) 2008-10-23

Family

ID=39512464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/087264 Ceased WO2008073979A2 (en) 2006-12-12 2007-12-12 Near-infrared electromagnetic modification of cellular steady- state membrane potentials

Country Status (6)

Country Link
EP (1) EP2089107A2 (en)
JP (1) JP2010512232A (en)
KR (1) KR20090097925A (en)
AU (1) AU2007333073A1 (en)
CA (1) CA2670711A1 (en)
WO (1) WO2008073979A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2349479B1 (en) * 2008-10-29 2015-08-26 Nomir Medical Technologies, Inc Near-infrared electromagnetic modification of cellular steady-state membrane potentials
RU2569707C2 (en) * 2010-01-21 2015-11-27 Конинклейке Филипс Электроникс Н.В. Control device, portable device and illuminating system for phototherapeutic purposes
US10702706B2 (en) 2013-07-16 2020-07-07 Nomir Medical Technologies, Inc. Apparatus, system, and method for generating photo-biologic minimum biofilm inhibitory concentration of infrared light
US20210106708A1 (en) * 2018-03-21 2021-04-15 Case Western Reserve University Thermoresponsive compositions and methods for preventing and disrupting biofilms
CN111175103B (en) * 2020-01-16 2023-07-04 江西业力医疗器械有限公司 A leucorrhea sample pretreatment liquid for fluorescent detection of fungal vaginitis and its preparation method
CN111781175B (en) * 2020-06-18 2023-04-21 中国人民解放军军事科学院国防科技创新研究院 Method, device and application for improving mitochondrial activity in cells

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042603A (en) * 1996-10-30 2000-03-28 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US20030130709A1 (en) * 2001-06-26 2003-07-10 D.C. Constance Haber Therapeutic methods using electromagnetic radiation
US20040034341A1 (en) * 1998-03-27 2004-02-19 Palomar Medical Technologies, Inc. Method and apparatus for the selective targeting of lipid-rich tissues
US20040111132A1 (en) * 2002-12-10 2004-06-10 Olga Shenderova Phototherapeutic treatment methods and apparatus
US20040156743A1 (en) * 2002-08-28 2004-08-12 Eric Bornstein Near infrared microbial elimination laser system
US20050075703A1 (en) * 2001-01-22 2005-04-07 Eric Larsen Photodynamic stimulation device and methods

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042603A (en) * 1996-10-30 2000-03-28 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US20040034341A1 (en) * 1998-03-27 2004-02-19 Palomar Medical Technologies, Inc. Method and apparatus for the selective targeting of lipid-rich tissues
US20050075703A1 (en) * 2001-01-22 2005-04-07 Eric Larsen Photodynamic stimulation device and methods
US20030130709A1 (en) * 2001-06-26 2003-07-10 D.C. Constance Haber Therapeutic methods using electromagnetic radiation
US20040156743A1 (en) * 2002-08-28 2004-08-12 Eric Bornstein Near infrared microbial elimination laser system
US20040111132A1 (en) * 2002-12-10 2004-06-10 Olga Shenderova Phototherapeutic treatment methods and apparatus

Also Published As

Publication number Publication date
KR20090097925A (en) 2009-09-16
JP2010512232A (en) 2010-04-22
CA2670711A1 (en) 2008-06-19
WO2008073979A2 (en) 2008-06-19
AU2007333073A1 (en) 2008-06-19
EP2089107A2 (en) 2009-08-19

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