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WO2008067119A3 - Novel compounds - Google Patents

Novel compounds Download PDF

Info

Publication number
WO2008067119A3
WO2008067119A3 PCT/US2007/083568 US2007083568W WO2008067119A3 WO 2008067119 A3 WO2008067119 A3 WO 2008067119A3 US 2007083568 W US2007083568 W US 2007083568W WO 2008067119 A3 WO2008067119 A3 WO 2008067119A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel compounds
compositions
azaindole derivatives
medicaments
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/083568
Other languages
French (fr)
Other versions
WO2008067119A2 (en
Inventor
Jun Tang
Toshihiro Hamajima
George Maclean Adjabeng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of WO2008067119A2 publication Critical patent/WO2008067119A2/en
Publication of WO2008067119A3 publication Critical patent/WO2008067119A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to azaindole derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such azaindole derivatives are potentially useful in the treatment of diseases associated with inappropriate c-Met activity and/or B-Raf kinase activity. A compound of Formula (I):
PCT/US2007/083568 2006-11-27 2007-11-05 Novel compounds Ceased WO2008067119A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86724606P 2006-11-27 2006-11-27
US60/867,246 2006-11-27

Publications (2)

Publication Number Publication Date
WO2008067119A2 WO2008067119A2 (en) 2008-06-05
WO2008067119A3 true WO2008067119A3 (en) 2008-08-21

Family

ID=39468597

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/083568 Ceased WO2008067119A2 (en) 2006-11-27 2007-11-05 Novel compounds

Country Status (1)

Country Link
WO (1) WO2008067119A2 (en)

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SI3184526T1 (en) 2005-12-13 2019-03-29 Incyte Holdings Corporation Pyrrolo(2,3-d)pyrimidine derivatives as janus kinase inhibitor
MX2009013402A (en) 2007-06-13 2010-02-24 Incyte Corp Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]py rimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile.
WO2010135621A1 (en) 2009-05-22 2010-11-25 Incyte Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
WO2010135650A1 (en) 2009-05-22 2010-11-25 Incyte Corporation N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
CA2771338A1 (en) * 2009-09-30 2011-04-07 Merck Sharp & Dohme Corp. Crystalline hydrochloride salts of c-met kinase inhibitors
PE20130038A1 (en) 2010-03-10 2013-01-28 Incyte Corp PIPERIDIN-4-IL AZETHYDINE DERIVATIVES AS JAK1 INHIBITORS
SG10201503983QA (en) 2010-05-21 2015-06-29 Incyte Corp Topical Formulation for a JAK Inhibitor
EP2588107A1 (en) 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
BR112013012502A2 (en) 2010-11-19 2019-03-06 Incyte Corporation substituted cyclobutyl pyrrolopyridine and derivative pyrrolopyrimidine derivatives as jak inhibitors
EP2640725B1 (en) 2010-11-19 2015-01-07 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
EP2721028B1 (en) 2011-06-20 2015-11-04 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (en) 2011-08-18 2013-04-01 Incyte Corp Cyclohexyl azetidine derivatives as JAK inhibitors
UA111854C2 (en) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS
AR091079A1 (en) 2012-05-18 2014-12-30 Incyte Corp DERIVATIVES OF PIRROLOPIRIMIDINA AND PIRROLOPIRIDINA REPLACED WITH PIPERIDINILCICLOBUTILO AS JAK INHIBITORS
PL2919766T3 (en) 2012-11-15 2021-10-04 Incyte Holdings Corporation PROLONGED RELEASE RUSSOLITINB DOSAGE FORMS
EP3489239B1 (en) 2013-03-06 2021-09-15 Incyte Holdings Corporation Processes and intermediates for making a jak inhibitor
LT3030227T (en) 2013-08-07 2020-06-10 Incyte Corporation DURED RELEASE JAK1 INHIBITOR DOSAGE FORMS
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
ES2764299T3 (en) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Human monoclonal antibodies against AXL
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
AR113922A1 (en) 2017-12-08 2020-07-01 Incyte Corp LOW DOSE COMBINATION THERAPY FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS
MX2020007973A (en) 2018-01-30 2020-12-07 Incyte Corp Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicot inyl)piperidine-4-one).
SI3773593T1 (en) 2018-03-30 2024-08-30 Incyte Corporation TREATMENT OF HIDRADENITIS SUPPURATIVE WITH JAK INHIBITORS
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174889B1 (en) * 1996-07-13 2001-01-16 Glaxo Wellcome Inc. Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174889B1 (en) * 1996-07-13 2001-01-16 Glaxo Wellcome Inc. Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHIERING ET AL.: "Crystal Structure of the Tyrosine Kinase Domaine of the Hepatocyte Growth Factor Receptor c-Met and Its Complex with the Microbial Alkaloid K-252A", PROC. NTNL. ACAD. SCI., vol. 100, October 2003 (2003-10-01), pages 12654 - 12659, XP002491742 *

Also Published As

Publication number Publication date
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