WO2008053942A1 - Composition for throat - Google Patents

Abstract

It is intended to provide a composition for throat having an effect of improving vocalization, particularly an effect of preventing voice disorders. The composition for throat of the invention includes a liquid composition for throat which contains a water-soluble solid component of black beans at a ratio of from 4 to 20% by weight and has a viscosity of from 50 to 36,000 mPa•s, and a composition for throat which contains a water-soluble solid component of black beans and a potassium-containing material at a ratio that satisfies the relationship represented by the following formula (I): Y ≥ 0.6285X-0.7276(I) X: Concentration (% byweight) of potassium ion derived from potassium-containing material in the composition Y: Concentration (% by weight) of water-soluble solid component of black beans in the composition (with the proviso that Y ≥ 0.5% by weight)

Description

 Specification

 Throat composition

 Technical field

 TECHNICAL FIELD [0001] The present invention relates to a composition for a throat having a voice improvement effect, particularly a voice disorder prevention effect.

 [0002] The act of “speaking” expresses information, will, emotions, etc., and is able to communicate with others. To get. If smooth voicing is hindered, in addition to causing inconveniences in daily life, it also acts on the psychological side and causes stress. Therefore, it is considered important to enable “speech”, especially “smooth utterance”, from the viewpoint of improving the quality of life (QOL).

 [0003] On the other hand, the efficacy of pharmaceuticals and functional foods in the existing pharyngeal and laryngeal region is mainly intended for the treatment and prevention of various symptoms such as antibacterial, anti-inflammatory, antitussive and expectorant diseases in the throat. In fact, it is easy to utter (improvement of utterance), that is, from the viewpoint of QOL and re, it is fully considered.

 [0004] Black bean soup has long been used as a folk medicine for the purpose of suppressing voice drowning and coughing, and it is known that black beans have an effect on the throat and voice (for example, Non-patent document 1). For this reason, an extract extracted from black beans is pulverized as it is by a conventional method such as liquid or spray dry and blended as a food material has been proposed as a food with antitussive effect if the voice is suppressed ( (See Patent Documents 1-2). Non-patent document 1: Clinical and research, 75, No.12, 2625 (1998)

 Patent Document 1: Japanese Patent Laid-Open No. 2005-120061

 Patent Document 2: JP 2005-239701 A

 Disclosure of the invention

 Problems to be solved by the invention

[0005] The present invention is a plant-derived component having a food experience and high safety, specifically, a black bean-derived component. An object of the present invention is to provide a composition for throat which has an excellent ingredient for improving voice production. Another object of the present invention is to provide a throat composition prepared so that it can be taken orally as a food or a favorite product by suppressing the bitterness derived from black beans.

 Means for solving the problem

[0006] The inventors of the present invention have been diligently studying day and night in order to achieve the above-mentioned object. It was found that the composition of the liquid composition was adjusted to have a viscosity of 50 mPa's or more using an agent, and that it was excellent in adhesion to the throat when ingested, and exhibited an excellent voice improvement effect. Further, to adjust the viscosity of the liquid composition in the range of 50~36,000mPa _'S, by suppressing the ratio of the water soluble solids of the black beans 20 wt% or less, that the black beans peculiar bitterness is suppressed As a result, it was confirmed that such a liquid composition was suitable for oral intake for the purpose of improving vocalization. The liquid throat composition of the present invention has been completed based on strength and knowledge.

 [0007] (D i m

 That is, the present invention is a liquid throat composition described in the following (1-1) to (1-14).

 (1-1) A liquid throat composition having a viscosity of 50 to 36,0000 ^ & '3, containing 4 to 20% by weight of water-soluble solids of black beans.

 [0008] (1-2) The liquid throat composition according to (1-1), comprising a black bean solvent extract as an active ingredient.

[0009] (1-3) The liquid throat composition according to (1-2), wherein the black bean solvent extract is obtained by enzymatic treatment of the black bean solvent extract.

[0010] (1-4) The enzyme treatment is a treatment using at least one enzyme selected from the group consisting of an enzyme having a proteolytic activity and an enzyme having a saccharide-degrading activity.

(1-3) The composition for liquid throats described in (1-3).

[0011] (1-5) The liquid throat composition according to (1-3), wherein the enzyme treatment is a treatment using an enzyme having a saccharide-degrading activity.

[0012] (1-6) The liquid throat composition according to any one of (g) to (1) to (1-5), further comprising a viscosity-imparting agent. (1-7) Viscosity imparting power S, locust bean gum, tamarind seed gum, pullulan, xanthan gum, guar gum, tara gum, rhamzan gum, thickening polysaccharide consisting of mannan, inulin and polydextros, and molasses, The liquid throat composition according to (1-6), which is at least one selected from the group consisting of honey, fructose-glucose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate and sugar syrup consisting of starch syrup.

 [0014] (I-8) The liquid throat composition according to any one of (1-1) to (1-7), having a pH in the range of 5-9.

 [0015] (1-9) Use of a liquid composition containing 4 to 20% by weight of water-soluble solids of black beans and having a viscosity of 50 to 36,000 mPas as a throat composition.

 [0016] (1-10) Use of a liquid composition containing 4 to 20% by weight of water-soluble solids of black beans and having a viscosity of 50 to 36,000 mPa · s for the preparation of a throat composition .

 [0017] (1-11) The use according to 0-9) or (1-10), wherein the composition for throat is a dysphonia preventive agent or an dysphonia improving agent.

 [0018] (1-12) The liquid throat composition according to (1-1) to (1-8), V, which is used as a dysphonia preventive agent or a dysphonia improving agent.

 [0019] (1-13) Prevention or improvement of dysphonia, comprising subjecting the subject to the liquid throat composition described in any one of (1-1) to (1-8)! Method.

 [0020] (1-14) The liquid throat composition described in (1-1) to (1-8)! /, Which is misplaced, is orally ingested by a subject before or during speaking. How to prevent dysphonia.

 [0021] Further, the present inventors have found that the water-soluble solid content of black beans is less than 4 wt%! /, Or even if the viscosity is less than 50 mPa's. It has been found that an excellent voice improvement effect can be obtained by orally ingesting a composition containing a specific amount of potassium. According to the composition, it is prepared into a liquid or semi-solid having an arbitrary viscosity not limited to the above-mentioned predetermined viscosity, or prepared into a solid having an arbitrary form such as a wearable or troche. It was confirmed that it can be provided as an oral composition having various forms. The present invention has been completed based on such findings, and provides the following throat composition.

[0022] (II) Throat composition (II-l) A composition for throat containing a water-soluble solid content of black beans and a potassium-containing substance in a proportion that satisfies the relationship of the following formula (I):

 [0023] country

Y ≥ 0. 6 2 8 5 X ^{0 7276} (I)

 X: Potassium ion concentration derived from the potassium-containing material in the composition (wt%) Y: Black bean water-soluble solid content concentration in the composition (wt%) (Y≥0.5 wt <½)

 (Π-2) The throat composition according to (Π-1), comprising a black bean solvent extract as an active ingredient.

[0025] (Π-3) The throat composition described in (ΙΙ-2), wherein the black bean solvent extract is obtained by enzymatic treatment of the black bean solvent extract.

(ΙΙ-4) The enzyme treatment is a treatment using at least one enzyme selected from the group consisting of an enzyme having a proteolytic activity and an enzyme having a saccharide-degrading activity (Π The composition for throat described in 3).

(ΙΙ-5) The throat composition described in (Π-3), wherein the enzyme treatment is a treatment using an enzyme having a saccharide-degrading activity.

(Π-6) The black bean water-soluble solid content concentration in the composition is 0.5 to 20% by weight (Π-1) to (II-

The composition for throat described in 5)! /.

[0029] Potassium ion concentration derived from ([pi-7) containing potassium in the composition is 0.0;! A ~ 2 weight _^0/0, the (II-1) to (ΙΙ-6) /, deviation A composition for throat as described above.

[0030] (ΙΙ-8) The composition for throat according to any one of (Π-1) to (Π-7), which is a composition having ρΗ in the oral cavity of 5 to 9.

[0031] (Π-9) Throat composition power The composition for throat described in (II-1) Noso (ΙΙ-8)! /, Which is either a liquid composition or a solid composition.

(11-10) The solid throat composition is a chewable tablet, a troche, or a sputum. (II

-9).

 [0033] (Π-11) The relationship between the water-soluble solid content of black beans and the potassium-containing material is represented by the following formula (I):

 [0034] [Equation 2]

≥ ≥ 0 ^.6 2 8 5 X ^{0 7276} (I)

X: Concentration of strength rium ion derived from the content of strength rium in the composition (wt%) Υ: Concentration of water soluble solids in black beans in the composition (wt%) (however, Υ≥0.5 wt <½) [0035] Use of a composition containing such a ratio as follows as a throat composition.

 [0036] (11-12) The relationship between the water-soluble solid content of black beans and the potassium-containing material is represented by the following formula (I):

 [0037] [Equation 3]

Y ≥ 0. 6 2 8 5 X ^{0 7276} (I)

 X: Potassium ion concentration derived from the potassium-containing material in the composition (wt%) Y: Black bean water-soluble solid content concentration in the composition (wt%) (Y≥0.5 wt <½)

 [0038] Use of a composition containing such a ratio for the preparation of a throat composition.

[0039] (11-13) The use according to (Π-11) or (II-12), wherein the throat composition is a dysphonia preventive or dysphonia ameliorating agent.

[0040] (11-14) (Π-1) to (Π-10) used as a dysphonia prevention agent or an dysphonia improving agent

), The composition for throat.

[0041] (11-15) A method for preventing or improving vocal dysfunction, comprising orally ingesting a throat composition described in any one of (! -1) to (11-10)!

[0042] (11-16) Voice production comprising orally ingesting a throat composition described in any one of (Π-1) to (11-10) before or during vocalization of the composition for throat Failure prevention method.

 The invention's effect

 [0043] The throat composition of the present invention is characterized by having an excellent voice improvement action, particularly a voice disorder prevention action. The liquid throat composition of the present invention is excellent in adhesion persistence to the throat when ingested orally, and as a result, can act on the throat for a long time.

 [0044] For this reason, it is excellent in the effect of improving throat symptoms (voice dysfunction) such as the tendency to drown, throat fatigue, or difficulty in vocalization, or the prevention of such an occurrence in advance. ing. In particular, the liquid throat composition of the present invention obtains the above-mentioned excellent speech improvement effect by ingesting before singing, such as singing such as karaoke, presentation, speech, drama and lecture. be able to. In addition, the liquid throat composition of the present invention has been devised so that a black bean ingredient with a high safety with eating experience is an active ingredient and the bitter taste derived from the black bean ingredient is not expressed, so that it is only as a pharmaceutical product. Nagu It can be effectively used as a daily ingested food.

[0045] Further, the throat composition of the present invention comprises a highly safe black bean ingredient with a dietary experience as an effective component, and also exhibits an excellent voice improvement effect without being restricted by viscosity or its shape. Therefore, it can be effectively used not only as a medicine but also as a food that is ingested on a daily basis (for example, beverages, syrups, and sweets such as chewables, troches, and strawberries).

[0046] The "voice improvement action" as used in the present invention is an action that maintains a normal state (smooth utterance) of a utterance in a voice used in daily conversation or a singing voice used in singing. It means the action of promptly returning speech from an abnormal state to a normal state. “Maintaining utterance in a normal state” means, in other words, “effect of preventing normal utterance to abnormal utterance (speech disorder)” (in the present invention! / In other words, “the effect of promptly returning the utterance from the abnormal state to the normal state” means, in other words, “the effect of improving the abnormal utterance (speech disorder) to the normal utterance” "(In the present invention! /, Also referred to as" a speech disorder improving effect "). The throat composition targeted by the present invention preferably has a `` voice disorder prevention effect '', and more preferably has both a `` voice disorder prevention effect '' and a `` voice disorder improvement effect ''! / What is it.

 BEST MODE FOR CARRYING OUT THE INVENTION

 0047] (D i m

 The present invention is a liquid throat composition prepared from black beans as a raw material. The liquid throat composition contains 4 to 20% by weight of a black soybean water-soluble solid and is adjusted to have a viscosity of 50 mPa's or more, preferably 50 to 36,000 mPa's. It is characterized by

[0048] Here, the water-soluble solid content of black beans is a general term for water-soluble components derived from black beans, and generally includes substances that dissolve in water, such as sugars, salts, soluble proteins, and acids. Used as a content index. Such a water-soluble solid content is generally determined by a force S obtained with a refractometer for sugar.

 [0049] The water-soluble solid content of black beans contained in the liquid throat composition of the present invention may be contained in a proportion of 4 to 20% by weight as described above, preferably 5 to 20% by weight, More preferred is 6 to 20% by weight, still more preferred is 6 to 18% by weight.

[0050] The liquid throat composition of the present invention contains a processed black bean so that the water-soluble solid content of black beans is in the above-mentioned ratio, as long as the water-soluble solid content of black beans is in the above-mentioned ratio. In In this regard, the type and form of the processed black bean to be blended are not particularly limited. A black bean solvent extract is preferred.

 [0051] Black beans are black seeds (grains) (black soybeans) of a short-day annual plant belonging to the leguminous soybean species Glycine max (Shi) Merrill. The black beans can be seeds of any varieties as long as they have varieties such as Meiko Koguro, Tokachikuro, Iwakuro, Tamadakuro, Tamba Black, Shinano Black, and Goku.

 [0052] Examples of the extraction solvent used for the preparation of the black bean solvent extract include water, a polar organic solvent, or a mixture thereof. Examples of the polar organic solvent include alcohol, acetonitrile, ethyl acetate and the like. In particular, from the viewpoint of safety to the human body and handling, it is possible to list water, lower alcohols, or a mixture thereof as the extraction solvent. Examples of the lower alcohol include C1-C4 lower alcohols such as methanol, ethanol, propanol, isopropyl alcohol, and butanol, preferably ethanol. The extraction solvent is preferably water or hydrous alcohol (particularly hydrous ethanol). When water-containing alcohol (especially water-containing ethanol) is used as the solvent, the amount of alcohol (ethanol) contained therein is preferably 40% by volume or less.

Yes

 [0053] It should be noted that the extraction solvent is adjusted to be acidic! /! The adjustment to acidity can be carried out using an inorganic acid such as hydrochloric acid, sulfuric acid or phosphoric acid, or an organic acid such as citrate or malic acid so that the pH is in the range of about 2 to 5.5.

 [0054] As the extraction method, a generally used method can be employed. No limitation, for example, a method of immersing raw or dried black beans (as is, or crude powder, shredded product) in a solvent under low temperature, normal temperature, heating or boiling conditions; low temperature, normal temperature, heating or Examples include extraction with stirring under boiling conditions; supercritical extraction using carbon dioxide or the like; or bar-collation method. Preferably, the dried black bean (as-is, or crude powder, shredded product) is immersed in a solvent under high temperature or boiling conditions, and extracted with stirring as necessary (heat treatment). Extraction method).

[0055] From the obtained extract, solids (residues) unnecessary for the solvent can be removed by various solid-liquid separation means such as filtration, coprecipitation, centrifugation, and pressing as necessary. Also obtained The extract can be further freeze-dried or concentrated to prepare a powdery or pasty extract (concentrated extract).

 [0056] Although not limited, in order to remove an unpleasant odor, taste or / and color, the black bean extract obtained above is further subjected to an enzyme treatment or / and a molecular weight of 500 00 to 25000. It is also possible to perform any combination of fractionation processes.

 Here, examples of the enzyme used for the enzyme treatment include an enzyme having an action of degrading a sugar or / and a protein. Specifically, for example, as the former saccharide-degrading enzymes, amylases such as Christase Y (manufactured by Yamato Kasei) and Sumiteam S (manufactured by Shinnippon Chemical Co., Ltd.); Cellulase A (manufactured by Amano Enzym), Cellulases such as AC40 (manufactured by HIBI); enzymes having saccharide-degrading activity such as hemicellulase such as sucrase S (manufactured by Sankyo) and Sumiteam X (manufactured by Shin Nippon Kagaku Co., Ltd.) can be used. In addition, the latter proteolytic enzymes include acidase proteases such as Neurase A (manufactured by Amano Enzyme) and Protease YP-SS (manufactured by Yakult Pharmaceutical Co., Ltd.); Neutral proteases such as Tokasei Kogyo Co., Ltd .; enzymes having proteolytic activity such as alkaline proteases such as Novozym FM (Novozymes) Nyabioprase SP-4FG (Nagase ChemteX) can be used.

 [0058] Such an enzyme having a saccharide-degrading activity and an enzyme having a proteolytic activity can be used singly or in combination. The enzyme to be used may be a single enzyme, but various enzymes may be used in combination. A preferred enzyme is an enzyme having a saccharide-degrading activity, and in particular, an enzyme having an activity of degrading a polysaccharide such as the above-mentioned cellulase, amylase, hemicellulase or the like can be suitably used.

 [0059] The enzyme treatment can be carried out under predetermined conditions suitable for each enzyme used. The temperature conditions for performing the enzyme treatment are not particularly limited, but a range of 30 to 80 ° C can be usually used. Preferably it is 35-60 degreeC.

[0060] Examples of the fractionation treatment with a molecular weight of 5000 to 25000 include a gel filtration method, a membrane separation method, and an adsorption treatment method. A membrane separation method is preferred. The membrane separation method used here is that the fraction of molecular weight 5000-25000 is extracted from the solvent extract of black beans. There is no particular limitation as long as it can be acquired. Specifically, separation and removal of high molecular weight compounds using membranes with a set molecular weight cut off, for example, in the range of about 20000 to 30000, preferably <is in the range of about 22000 to 28000, more preferably <is around 25000. And a method for separating and removing low molecular weight compounds using a membrane in the range of about 1000 to 8000, preferably in the range of about 3000 to 7000, more preferably around 5000. It is preferable to do in combination.

[0061] As a method of separating and removing the former polymer compound, specifically, an NTU-3150 membrane, an NTU-3250 membrane, an NTU-3550 membrane, an NTU-3800 UF membrane (with the molecular weight cut off within the above range) Cefilt-UF (manufactured by NGK); AHP-2013 membrane, AHP-3013 membrane, AHP-1010 membrane (above, manufactured by Asahi Kasei); etc. be able to. The latter method for separating and removing low molecular weight compounds is specifically NTR-7250 membrane, NTR-7410 membrane, NTR-7430 membrane, NTR-7450 membrane with molecular weight cut off within the above range (above, Nitto Denko), AIP-3013 membrane, ACP-3013 membrane, ACP-2013 membrane, AIP-2013 membrane, AIO-1010 membrane (above, manufactured by Asahi Kasei) and other reverse osmosis (RO) membrane treatment, Or use force S to raise ultrafiltration (UF) membrane treatment.

 [0062] The membrane material used for the force and membrane separation method may be natural, synthetic or semi-synthetic, for example, senorelose, cenololose diacetate or triacetate, polyamide, polysolephone, polystyrene, polyimide, polyacrylonitrile. And so on. In addition to the ultrafiltration membrane and reverse osmosis membrane, a microfiltration (MF) membrane or the like can also be used as the membrane used for the fractionation treatment.

[0063] The enzyme treatment and the molecular weight fractionation treatment can be performed alone or in combination with the black bean extract or the treated product. Moreover, when both are performed in combination, the enzyme treatment and the molecular weight fractionation treatment can be performed in any combination continuously or discontinuously. The order of the combination is not particularly limited, and any of the order of molecular weight fractionation after the enzyme treatment and the order of molecular weight fractionation after the molecular weight fractionation may be used, but the former method is preferred. In addition to the above enzyme treatment and fractionation treatment with a molecular weight of 5000-25000, the black bean extract or its treatment product is further subjected to normal purification such as acid treatment, extraction treatment, adsorption treatment, ion exchange treatment or membrane treatment. Can also be used for processing The These treatments can be performed on the black bean extract or the treated product, either alone or in combination of two or more.

 [0064] The solvent extract of black beans obtained in this way has a water-soluble solid content of black beans of 4 to 20% by weight, preferably 5 to 20 using a food solution such as water or ethanol as necessary. % By weight, more preferably 6 to 20% by weight, and even more preferably 6 to 18% by weight. At the same time, the viscosity is preferably increased by using a viscosity-imparting agent as described later. It is adjusted to be 50 mPa's or more, preferably 50 to 36,000 mPa-s.

 [0065] Here, the viscosity is a BL type rotational viscometer (with a rotor No.

 1. When the viscosity is measured at 12 rpm using a rotor 粘度 ο · 2 for a viscosity of 450 to 2250 mPa's, using a rotor 粘度 ο · 3 for a viscosity of 2250 to 9000 mPa's and using a rotor は ο.4 for a viscosity of 9000 mPa's or more) It means the viscosity obtained. In the entire specification, “viscosity” means a viscosity measured under such conditions.

 [0066] Adjustment of the viscosity of the liquid throat composition can usually be performed by blending a viscosity-imparting agent. Further, the above-mentioned food solvents such as water and ethanol may be used in combination with a viscosity-imparting agent.

 [0067] Here, as the viscosity imparting agent, the viscosity of the liquid composition containing 4 to 20% by weight of the water-soluble solid content of black beans is 50 mPa's or more, preferably 50 to 36,000 mPa's. There is no particular limitation as long as it can be used.

 [0068] For example, gums such as locust bean gum, tamarind seed gum, pullulan, xanthan gum, guar gum, tara gum, rhamzan gum and mannan; starch (hereinafter collectively referred to as “polysaccharide”); glucose, fructose Monosaccharides such as sucrose, lactose, trehalose, etc .; oligosaccharides consisting of trisaccharides or more; polysaccharides such as inulin and polydextrose; chickenpox; Sugar alcohol; molasses, honey, fructose dextrose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate, mixture of sugars such as starch syrup (these are also collectively referred to as “saccharides”). These can be used alone or in any combination of two or more.

[0069] Preferably, locust bean gum, tamarind seed gum, pullulan, guar gum, inu Polysaccharides such as phosphorus and polydextrose; and sugars such as molasses, honey, fructose glucose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate and starch syrup, more preferably sugars.

 [0070] The viscosity is not particularly limited as long as it is in the range of 50 to 36000 mPa's, preferably 6 O-lOOOOmPa-s, more preferably <is 90 to 8000 mPa-s.

 [0071] The liquid throat composition of the present invention is a fragrance, a coloring agent, a refreshing agent, an antioxidant, a sweetener or an antibacterial agent within the range not impairing the above characteristics (water-soluble solid content of black beans, viscosity). Other ingredients such as agents can also be added. Moreover, a potassium containing material can also be mix | blended. As will be described later, it is also possible to enhance the voice improvement effect of the liquid throat composition by blending a potassium-containing material. The potassium-containing material is not particularly limited as long as it contains a potassium salt. Examples include inorganic compounds such as potassium chloride, potassium carbonate, 2 potassium phosphate, 3 potassium phosphate, potassium darconate, 3 potassium citrate, potassium glutamate, and potassium hydrogen tartrate; and whey salt, seaweed ash extraction Cite, buckwheat ash extract, crude seawater potassium chloride, brine lake water sodium chloride, etc.

 [0072] The pH of the liquid throat composition of the present invention is usually in the range of pH 5 to 9, preferably pH 5 to 8, more preferably ρ 5 to 7.5. As shown in the experimental examples, when the pH is 4.8 or less, particularly 4.6 or less, the voice improvement effect tends to decrease.

 [0073] The liquid composition thus obtained is then sterilized to prepare a throat composition (viscosity at cooling (20 ° C); 50 to 36000 mPa's). The sterilization treatment is not particularly limited, but normal heat sterilization can be used.

[0074] As the heat sterilization method, the power greatly fluctuates depending on the contained components or the pH. For example, pasteurization by heating at 62 to 65 ° C for about 30 minutes, sterilization at 72 to 75 ° C for about 15 seconds Sterilization, UHT sterilization that heats at about 150 ° C for about 2 to 3 seconds, and retort sterilization that heats at about 120 ° C for about 4 minutes are known. The liquid throat composition according to the present invention is not particularly limited as long as it does not impair the voicing improvement effect of the active ingredient of black beans, and is not particularly limited as long as it is heat sterilized, usually 80 to; Sterilization, or 115 ~; preferably, sterilization of retort at 135 ° C for 4-30 minutes. [0075] The liquid throat composition of the present invention may be a spray-type, drip-type, or discharge-type throat preparation (including food). Various containers such as bottles, pumps, sprays, and tubes can be used as the containers used for the above-mentioned types of preparations.

 [0076] As shown in Experimental Example 1 described later, the liquid composition of the present invention thus prepared has a voice improvement effect, particularly a voice disturbance prevention action. Therefore, the liquid composition can be suitably used as it is as a composition for the throat, and as a dysphonia prevention agent or an utterance improving agent.

 [0077] (II) Throat composition

 Here, the throat composition targeted by the present invention is prepared from black beans as a raw material, and additionally contains a potassium-containing material, in the same manner as the liquid throat composition described above.

 [0078] The throat composition is characterized in that it contains a water-soluble solid content of black beans and a potassium-containing material in a proportion that is related to the following formula (I):

 [0079] 圖

Y ≥ 0. 6 2 8 5 X ^{0 7276} (I)

 X: Concentration of strength rium ion derived from the content of strength rime in the composition (wt%) Y: Concentration of black bean water-soluble solids in the composition (wt%) (Y≥0.5 wt <½)

 [0080] The proportion of the water-soluble solid content of black beans contained in the composition is 0.5% by weight or more, and the above formula is used for the potassium ion concentration derived from the power lithium-containing material contained in the composition. If it is a ratio which satisfy | fills, it will not restrict | limit in particular. Preferably, 0.5 to; 18 wt%, more preferably 0.5 to 12 wt%, still more preferably 0.5 to 10 wt%.

[0081] The throat composition of the present invention contains a processed black bean product in such a proportion that the water-soluble solid content of the black bean satisfies the above conditions. As with the liquid throat composition described above, as long as the water-soluble solid content of black beans is in the above ratio, the type and form of the processed black bean are not particularly limited, but a black bean solvent extract is preferred. The method for preparing the black bean solvent extract is as described above. As described above, the black bean solvent extract is treated with an enzyme or / and a molecular weight of 5000 to remove the unpleasant odor, taste or / and color as described above. ~ 25000 fraction processing can be done in any combination! /. [0082] Furthermore, the throat composition of the present invention contains a potassium-containing material in such a ratio that the content of potassium ions derived from the potassium-containing material satisfies the above-mentioned conditions. The ratio of the potassium-containing material contained in the throat composition of the present invention is not particularly limited as long as it satisfies the above formula with respect to the water-soluble solid content of black beans! Preferably, 0.0;! To 2% by weight, more preferably 0.01 to;!% By weight, and still more preferably 0.02 to 0.6% by weight.

 Here, the potassium-containing material is not particularly limited as long as it contains a potassium salt. Examples include inorganic compounds such as potassium chloride, potassium carbonate, 2 potassium phosphate, 3 potassium phosphate, potassium dalconate, 3 potassium citrate, potassium glutamate, and potassium hydrogen tartrate; and whey salt, seaweed ash Examples include extracts, buckwheat ash extracts, crude seawater potassium chloride, and saltwater lake water chloride sodium chloride.

 [0084] The throat composition of the present invention includes a fragrance, a colorant, a refreshing agent, an anti-oxidant, and the like within a range that does not impair the above characteristics (water-soluble solid content of black beans and content of potassium ions derived from potassium-containing material). Other ingredients such as oxidizing agents, sweeteners or antibacterial agents can also be included.

 [0085] Further, the throat composition of the present invention is preferably prepared so that it usually has a pH in the range of 5 to 9 in the oral cavity after eating or taking. The pH in the oral cavity is preferably pH 5 to 8, more preferably ρΗ5 to 7.5. This is because, as shown in the experimental examples, when the pH in the oral cavity is 4.8 or less, particularly 4.6 or less, the voice improvement effect tends to decrease. In order to satisfy this pH condition, the throat composition of the present invention is preferably adjusted to be in the range of ρΗ5 to 8, preferably ρΗ5.5 to 7.5.

 [0086] As shown in Experimental Example 2 to be described later, the composition of the present invention thus prepared has a voice improvement action, particularly a voice disorder prevention action. Therefore, the composition can be used as it is as a throat composition, and as an agent for preventing or improving speech production.

[0087] The viscosity and shape of the throat composition of the present invention are not particularly limited as long as it contains the water-soluble solid content of black beans and the potassium-containing material in the above-mentioned proportions. For example, it can be arbitrarily prepared into a liquid composition and a semi-solid or solid composition. [0088] The throat composition having a liquid form can be prepared using water (purified water, ionic water, etc.) and a food solvent such as ethanol, and if necessary, the pH can be adjusted using a buffer. It can also adjust so that it may become the said range. These liquid compositions can also be prepared in the form of normal beverages, which can be spray-type, drop-type, or discharge-type throat preparations (including food). As the container used to make each type of the above-mentioned preparations, it is necessary to use various containers such as bottles, pumps, sprays, and tubes.

 [0089] The throat composition having a semi-solid or solid form is not particularly limited as long as it has an oral administration (or oral ingestion) form. For example, it can be made into solid preparations for oral administration such as powders, tablets, granules, pills, lozenges, syrups, wearable tablets and dry syrups. Moreover, you may have a form of a candy, a jelly, a gummi, and gum. A solid composition having a dosage form can be prepared according to conventional methods in the art.

[0090] The throat composition of the present invention may be formulated with various carriers and additives that are pharmaceutically acceptable for oral administration in order to prepare the oral dosage form and to stabilize the composition. (For example, see the Pharmacopoeia or “Pharmaceutical Additives Encyclopedia” (published by Yakuji Nippo)

[0091] Carriers or additives for oral administration or oral ingestion include lactose, sucrose, glucose, mannitol, sonorebitol, corn starch, partially pregelatinized starch, crystalline senorelose, low-substituted hydroxypropylcellulose, cano Excipients such as remellose sodium, talc; starch, α-starch, agar, gelatin, gum arabic, dextrin, methylcellulose, ethinoresenorelose, polyvinylinopyrrolidone, hydroxypropinoremethinoresenorelose, hydroxypropyl Binders such as cellulose, carboxymethyl cellulose or salts thereof, crystalline cellulose; calcium carbonate, crospovidone, starch, carboxymethyl cellulose calcium, low-substituted hydroxypropyl cellulose, carboxymethyl starch Disintegrating agents such as: magnesium stearate, talc, polyethylene glycol, anhydrous, such as anhydrous key acid; suspending agents such as polysorbate 80, polyoxyethylene hydrogenated castor oil, and pull nick; white sugar, talc, precipitated carbonic acid Calcium, gelatin, gum arabic , Pullulan, carnauba wax, hydroxypropyl methyl phthalate and the like coating agents; sucrose, glucose, sodium saccharin, sonorebithonole, citrate, and aspartame. In addition to the above components, as long as the effects of the present invention are not impaired, stabilizers, emulsifiers, dispersants, fluidizing agents, buffering agents, wetting agents, interfaces, which are usually acceptable as additives for pharmaceuticals or foods. Optional components such as activators, thickeners, preservatives, pH adjusters, colorants, solvents, and solubilizing agents can be added as desired.

[0092] The throat composition of the present invention is prepared in the aforementioned solid, semi-solid or liquid oral form and can be administered or ingested. The method of administration or ingestion and the timing thereof are not limited, but preferably, the water-soluble solid content of black beans is 0.2- It is preferable to administer (ingest) at a rate of 0. 4g.

 Example

 [0093] In the following, experimental examples and formulation examples will be described in order to clarify the constitution and effects of the present invention. However, the present invention is not affected by these experimental examples.

 [0094] Reference Example 1 Preparation of black bean concentrate extract (water-soluble solid content 70 wt%)

 10 kg of leguminous plant (black soybean: Glycine max) seeds (black beans) were added to 70 L of water and left overnight at room temperature, followed by boiling for 2 hours. The hot water extract thus obtained was subjected to solid-liquid separation, and the obtained extract was mixed with a filter aid and diatomaceous earth and subjected to suction filtration to obtain about 55 L (pH 5. 8) of a filtrate. Add 10g of enzyme cellulase (Cellulosin AC40 (manufactured by HIBI), titer: 4000units / g) to 55L (pH5.8) of the hot water extraction filtrate, and slowly stir at 40-55 ° C for treatment. An enzyme treatment solution was obtained. The enzyme-treated solution was then concentrated under reduced pressure to obtain 2.5 kg of a black bean concentrated extract (water-soluble solid content: 70% by weight).

 [0095] Experimental Example 1 Evaluation of speech improvement effect (Part 1)

As described later, the concentrated extract of black beans prepared in Reference Example 1 (water-soluble solid content: 70% by weight) and locust bean gum as a viscosity-imparting agent were used. A liquid composition (test samples 1 to 18) (see Table 1) was prepared. 6 healthy adult males (26-56) who are aware of their voice disturbances when these liquid compositions are uttered daily. (Year-old) (panelist) ingested and evaluated the voice improvement effect and bitterness.

[0096] Each liquid composition (test sample;! To 18) was ingested by placing each prepared liquid composition on the back of the tongue and swallowing it at once.

<Preparation of test sample>

 ω crane word expression ~ 5:

 Dilute black bean concentrate (water-soluble solid content 70% by weight) with water to give black beans water-soluble solid content 3, 6, 12, 18 and 24% by weight (test sample;! ~ 5) respectively A liquid composition was prepared. This was then sterilized at 90 ° C. for 20 minutes to give a low-viscosity liquid composition (viscosity 2-8 mPa's). The viscosity of the liquid composition is a BL type rotational viscometer (manufactured by Toki Sangyo Co., Ltd.) (uses rotor N0.1 up to a viscosity of 450 mPa's, viscosity greater than S450 mPa's and rotor N0 up to 2250 mPa's. .2 Use, Viscosity Measured at 20 ° C at 12 rpm with a rotor N 0.3 up to 9000 mPa 's up to 9000 mPa' s and a rotor N0.4 up to 9000 mPa 's same as below).

[0098] (2) Test sample 6 to 10:

 Dilute black bean concentrate (water-soluble solid content 70 wt%) with 1.5 wt% locust bean gum aqueous solution to obtain black beans water-soluble solid content 3, 6, 12, 18 and 24 wt% respectively. A liquid composition containing the test samples 6 to 10 was prepared. Next, this was sterilized at 90 ° C. for 20 minutes to obtain a highly viscous liquid composition (viscosity 3150-7450 mPa's).

[0099] (3) Test sample 11 to 14:

 Diluted black bean concentrate (water-soluble solid content 70% by weight) with various concentrations of locust bean gum aqueous solution so that the water-soluble solid content of black bean is 12% by weight (test sample 11 ~; 14) A viscous liquid composition was prepared. Next, this was sterilized at 90 ° C. for 20 minutes to obtain a liquid composition having a low to high viscosity (viscosity 11.5-557.5 mPa's).

[0100] (4) Test sample 15-: 18:

Diluted black bean concentrate (water-soluble solid content 70 wt%) with various concentrations of locust bean gum aqueous solution so that the water-soluble solid content of black beans is 6 wt% (test sample 15 to 18) A viscous liquid composition was prepared. Next, this was sterilized at 90 ° C. for 20 minutes to obtain a low to high viscosity liquid composition (viscosity 9.5 to 450 mPa ′s). [0101] <Test method>

Each of the above-prepared test samples;! To 18 was ingested by the panelists! /, And the voice improvement feeling evaluation test and the bitterness evaluation test described below were conducted. In addition, in order to obtain an equivalent amount of black bean extract, the liquid composition (test samples 5 and 10) with a water-soluble solid content of black beans of 24% by weight is lg, and the water-soluble solid content of black beans is 18%. % Liquid composition (test samples 4 and 9) is 1.3 g, liquid composition (test samples 3, 8, 11-14) containing 12% by weight of black beans in water-soluble solids is 2 _§ black water in water Liquid composition (test samples 2, 7, and 15--18) with 6% solids by weight solids, 8g liquid composition (test samples 1 and 6) with 3% by weight of water-soluble solids of black beans It was.

 [0102] (l s m

 Improving voicing when a book selected by the panelist is voluntarily read at a strength of f (forte) for 30 minutes and ingests a liquid composition (test sample) prepared from black bean extract before reading The feeling (a subjective auditory impression) was evaluated on the following five-level scale, compared with the case of not taking it.

 4: Remarkably improved

 3: I feel that it has improved considerably

 2: feel improved

 1: feel a little improved

 0: Do not feel improved.

[0103] If you do not take the test sample! / And read the book under the above conditions, your throat will get tired, your throat will be whispered and you will have difficulty speaking. In addition, the condition continues. In this experimental example, the feeling of voicing improvement is the length of the throat tiredness, throat dryness, voice faintness, ease of voice production, and duration after utterance when the test sample is ingested. This was evaluated comprehensively. When it is improved overall, it is judged as improved.

Yes

 [0104] The evaluation was performed once a day in the morning. In addition, there was an hour between the test when the sample was not taken and the test when the sample was taken.

[0105] (2) ^ ¾ 言 平 ¼word expression, experiment When the above voice improvement feeling evaluation test was performed, the bitter feeling felt when the sample was taken at the same time was evaluated according to the following four scales.

 3: I feel a bitter taste

 2: Feel bitter

 1: I feel a little bitterness

 0: Does not feel bitter.

[0106] <Result>

 The results are shown in Table 1.

 [0107] Note that the feeling of improvement in utterance and the feeling of bitterness are the sum of the scores of the six panelists. The higher the score, the higher the voicing improvement effect, and the lower the score, the lower the bitterness, the less bitter.

 [0108] [Table 1]

 [0109] The low viscosity liquid composition (viscosity 2-8mPa's) of test sample;! ~ 5 is almost as high as 24% by weight when the water-soluble solid content of black beans is less than 18% When the concentration was reached, an excellent feeling of improvement in vocalization was exhibited, but it became a hindrance to oral intake due to its strong bitterness.

[0110] On the other hand, a liquid composition (viscosity 31) to which viscosity was imparted with a viscosity-imparting agent as in test samples 6 to 10 50 ~ 7450mPa 's) is an oral solution that has excellent voicing improvement and almost no bitterness even if the water-soluble solid content of black beans is 6 ~; 18% by weight. There were no problems with intake. This is thought to be due to the fact that the time for adhering to the throat region and the remaining time became longer by thickening the liquid composition. However, even in this case, when the water-soluble solid content of black beans was as low as 3% by weight as in the test sample 6, no improvement in vocalization was obtained. Similarly to Test Sample 5, when the water-soluble solid content of black beans was as high as 24% by weight, bitterness was strongly expressed, which hindered oral intake.

 [0111] When the water-soluble solid content of black beans was fixed to 12% by weight as in test samples 11 to 14, and the water-soluble solid content of black beans was fixed to 6% by weight as in test samples 15 to 18 In any case, by adjusting the viscosity to 50 mPa's or more, preferably 60 mPa's or more, excellent utterance improvement feeling is exhibited. From these facts, it has been found that the concentration of the water-soluble solid content of black beans contained in the liquid composition of the present invention and the viscosity of the liquid composition are extremely important for exerting a feeling of voice improvement.

 [0112] Formulation Examples 1-13

 From the results of Experimental Example 1, a liquid composition having a good voice improvement effect, no strength, no bitter taste, and no obstacle to oral intake has a water-soluble solid content of black beans of 4 to 20% by weight, preferably The viscosity is 5 to 20% by weight, more preferably 6 to 20% by weight, and the viscosity of the liquid composition is considered to be 50 mPa's or more, preferably 60 mPa's or more.

 [0113] Therefore, a liquid throat composition (black bean syrup) satisfying such conditions was prepared according to the prescriptions shown in Tables 2 and 3, and the voice improvement effect was observed according to the voice improvement feeling evaluation test described in Experimental Example 1. evaluated. The results are shown in Tables 2 and 3. The voice improvement effect shown in this table is the total score of the six panelists.

[0114] [Table 2] Ingredients Formulation Example 1 Formulation Example 2 Formulation Example 3 Formulation Example 4 Formulation Example 5 Black Bean Concentrated Extract

 86 86 172 86 86

(Water-soluble solid content 70%)

Mouth one locust bean gum * ¹ 8.3 - - - - tamarind seed gum * ² - 16.9 14.6 - - pullulan * ³ - - - 78.3 - honey - - 923 Sucralose 03 03 0.3 0.3 - water 904.4 895.8 812.1 834.4 - perfume 1 1 1 1 1

 1000 1000 1000 1000 1000 Black bean water-soluble solids (wt%) 6.02 6.02 12.04 6.02 6.02 Viscosity (mPa ■ s) 114 121 149 97 4300

PH 6.10 6.02 5.92 5.71 5.55 Sterilization conditions 121¾ / 20 minutes 121 ° C / 20 minutes 121 C / 20 minutes 121¾ / 20 minutes 90 分 / 20 minutes Speech improvement effect 16 16 18 16 18

* 1: Bistop D-2050 (Sanei 3F ■ F'I Co., Ltd.)

 * 2: Bistop D-2033 (Sanei; manufactured by T-F “E”)

 * 3: Bistop D-2081 (Sanei 3F ■ manufactured by F-I Co., Ltd.)

 [0115] [Table 3]

 Bistop D-3000 (manufactured by San-Ei Gen F / F I Co., Ltd.)

 Lightest I I I Syrup (manufactured by Danisco Japan Co., Ltd.)

 Agabe Nurin Syrup (manufactured by Agabe Co., Ltd.)

 Amarty Syrup (Towa Kasei Kogyo Co., Ltd.)

 P0-60 (Towa Kasei Kogyo Co., Ltd.)

 [0116] (1) Preparation of Liquid Throat Composition in Formulation Example 1

Locust bean gum (Bistop D-2050, Saneigen) as a viscosity-imparting agent in 904.4 g of water F.F.I. Co., Ltd.) 8 · 3g and sweetener (sucralose) 0.3g was added, dissolved by heating and stirring at 80 ° C for 10 minutes, and then the black bean concentrate extract prepared in Reference Example 1 (water-soluble (Solid content 70 wt%) 86 ₈ was added and stirred until uniform. To this was added perfume lg and autoclaved at 121 ° C for 20 minutes to prepare 1 kg of a liquid throat composition having a viscosity of 114 mPa's.

 [0117] (2) Preparation of Liquid Throat Compositions according to Formulation Examples 2 to 4 and 6

 As in Formulation Example 1, each component shown in Table 2 and Table 3 was blended in the proportions described, Formulation Examples 2 and 3 using tamarind seed gum as a viscosity-imparting agent, and pullulan as a viscosity-imparting agent were used. A liquid throat composition of Formulation 4 and Formula 6 using guar gum was prepared. The viscosities of Formulation Examples 2 to 4 and 6 were 121 mPa * s, 149 mPa * s, 97 mPa * s, and 453 mPa * s, respectively.

 [0118] (3) Preparation of Liquid Throat Composition in Formulation Example 5

913 g of honey was heated to 60 ° C. and slowly stirred to add 86 _§ black bean concentrated extract (water-soluble solid content 70 wt%) 86 _§ , and fragrance was added lg. This was sterilized by heating at 90 ° C for 20 minutes to prepare 1 kg of a liquid throat composition having a viscosity of 4300 mPa's.

[0119] (4) Preparation Examples 7 to 13: Preparation of 13 liquid throat compositions

 In the same manner as in Formulation Example 5, the components shown in Table 3 were blended in proportions and autoclaved at 90 ° C for 20 minutes to prepare Formulation Examples 7 to 13 each liquid throat composition. did.

[0120], Experiment 2

 Liquid composition having various water-soluble solid content and potassium ion concentration (test sample) using concentrated black bean extract (water-soluble solid content 70 wt%) prepared in Reference Example 1 and potassium chloride as potassium content 19-55) (see Tables 4-7). As in Experimental Example 1, each of these liquid compositions was ingested by 6 healthy adult men (26 to 56 years old) (panelists) who were aware of impaired voice when performing daily continuous utterances. The improvement effect was evaluated. Each liquid composition (test samples 19 to 55) was ingested by placing each prepared liquid composition on the back of the tongue and swallowing it at once.

[0121] <Preparation of test sample>

Concentrated black bean extract (70% water soluble solids) with water and / or honey , So that the water-soluble solid content of black beans is 0.25, 0.5, 1, 2, 4, 8, 16, 24 and 70% by weight, respectively, and the potassium ion is in the proportion of 0-3.776% by weight A liquid composition (test samples 22 to 55) was prepared. In addition, a liquid composition (test samples 19 to 21) containing no concentrated extract of black beans was also prepared. They were then sterilized at 90 ° C for 20 minutes. The viscosity of the liquid composition was measured at 20 ° C. at a rotational speed of 12 rpm using a BL type rotational viscometer (manufactured by Toki Sangyo Co., Ltd.) in the same manner as in Experimental Example 1.

 [0122] <Test method>

 Each of the test samples 19 to 55 prepared above was ingested by the paneler, and an utterance improvement feeling evaluation test was performed in the same manner as in Experimental Example 1. As for the intake amount, the liquid composition (test samples 22 and 23) containing 0.25% by weight of water-soluble solids of black beans has 4.0g of water-soluble solids of black beans so that an equivalent amount of black bean extract can be ingested. The liquid composition (test sample 24-30) of 0.5% by weight is 4.0g, and the liquid composition (test sample 3;!-34) of 1% by weight of black beans is 4.0g. The liquid composition (test sample 35-39) with a solid content of 2% by weight is 4.0g, and the liquid composition (test sample 40-43) with a water-soluble solid content of 4% by weight is 4.0g. The liquid composition (test sample 44-47) with a solid content of 8% by weight is 4.0g, and the water-soluble composition of black beans with a water content of 16% by weight (test sample 48-51) is 4.0g, with the water solubility of black beans. The liquid composition with a solid content of 24% by weight (test samples 52-53); The liquid composition (test samples 54 to 55) in which 70 g of the water-soluble solid content of black beans and black beans was 70% by weight was 0.3 g.

 [0123] <Result>

 The results are shown in Tables 4-7. The improvement in utterance is the sum of the scores of the six panelists. The higher the score is, the higher the score is! The higher the score, the higher the utterance improvement effect. In addition, based on the total score, we judged as follows:

 + + +: Overall score 19-24

 + +: Overall score 13 ~; 18

 +: Overall score 6 ~; 12

 : Overall score 0-5.

[0124] [Table 4] 19 20 21 22 23 24 25 26 27 28 Black bean concentrate extract 0 0 0 0.357 0.357 0.72 0.72 0.12 0.72 0.72 Water-soluble solid content 70%

 K C 1 0 0.6 1.8 3.6 7.2 1.2 1.8 3.6 1.2 1.2 Honey 100 99.4 98.2 0 0 0 0 0 49.04 74.4 Water 0 0 0 96.043 92.443 98.02 97.48 95.68 49.04 23.68 Black bean water-soluble solids 0 0 0 0.25 0.25 0.5 0.5 0.5 0.5 0.5

(Wt%)

Addition + (wt%) 0 0.314 0.941 1.883 3J76 0.628 0.941 1.883 0.628 0.628 Viscosity (mPa ■ s)>4000>4000> 4000 10 10 10 10 10 10 50> 50 Voice improvement effect-(0) _ (.)-(0)-(0)-(0)-(0) + (7) ++ (16)-(0) ++ (15)

] [Holy

39 40 41 42 43 44 45 46 47 48 Black bean concentrate extract 2.86 5.72 5.72 5.72 5.72 1 1.4 1 1.4 1 1.4 1 1.4 22.86 Water-soluble solid content 70%

KC 1 1.2 0.05 0.15 0.2 0.4 0.025 0.05 0.075 0.1 0 Honey 0 0 0 0 0 0 0 0 0 0 Water 95.94 94.23 94.18 94.08 93.88 88.575 88.55 88.525 88.5 77.14 Black bean water soluble solids 2.0 4.0 4.0 4.0 4.0 8.0 8.0 8.0 8.0 8.0 16 K + (height 0.628 0.026 0.078 0.132 0.278 0.013 0.026 0.039 0.052 0 amount ⁰ /.)

Viscosity (mPa ■ s) 10 10 10 10 10 10 10 10 10 10 10 Voice improvement effect +++ (23)-(0) + (6) ++ (15) ++ + (20)-(0) + (7) ++ (16) +++ (19)-(0)

49 50 51 52 53 54 55 Black bean concentrated extract 22.86 22.86 22.86 34.285 34.285 100 99.9 Water-soluble solid content 70%

 KC 1 0.025 1 0.0375 0.05 0 0.1 0 0.1 Honey 0: 0 0 0 0 0 0 Water 77.12 77.10 77.09 65.715 65.615 0 0 Black beans water soluble solids 16 16 16 24 24 70 70

 (Weight ¾)

 Addition K + (wt%) 0.013 0.02 0.026 0 0.052 0 0.053 Viscosity (mPa-s) <10 <10 <10 <10 <10> 5000> 5000 Speech improvement effect + (12) ++ (18) +++ (22 ) ++ (17) +++ (22) ++ (17) +++ (24)

[0128] Among these results, the added potassium ion concentration (wt./.) And black bean water-soluble solids (wt%) in test samples 25, 31, 36, 41, 45 and 49 for which a positive evaluation was obtained The relationship is shown in Table 8, and the relationship for each test sample is shown as a solid line (one-one) in Figs. Note that. Figure 1 shows the upper limits of the vertical axis (black bean water-soluble solid content%) and the horizontal axis (added potassium ion concentration%) of 20 wt% and 1 wt%, respectively. Figure 2 shows the upper limits of the vertical axis and horizontal axis. Are 70% by weight and 2% by weight, respectively.

 [0129] [Table 8]

 [0130] The relationship between the added potassium ion concentration (X) (wt%) and the black bean water-soluble solid content (Y) (wt%) in the test sample that showed a voice improvement effect was calculated from the formula calculated from the solid line in Fig. 1. It became as follows.

 [0131] [Number 5

Y ≥ 0. 6285 X " ⁰⁷²⁷⁶ (I)

 X: Potassium ion concentration derived from the potassium-containing material in the composition (wt%) Y: Black bean water-soluble solid concentration in the composition (wt%) (Y≥0.5 wt%)

[0132] In Figs. 1 and 2, the test samples 25, 31, 36, 41, 45 and 49 For samples 19 24 26 30 32 35 37 40 42 44 46 48 and 50 55, the relationship between added potassium ion concentration (% by weight) and black bean water-soluble solids (% by weight) It was described so that the relevance was strong.

 [0133] (Symbol in the figure)

 Speech improvement effect + + +: ·

 Speech improvement effect + +: Country

 Speech improvement effect +: A

 Speech improvement effect X

 [0134] From these results, it was found that the test sample in which the added potassium ion concentration and the black bean water-soluble solid content satisfy the above formula has an effect of improving speech.

 [0135] Formulation Examples 14 to 17

 From the results of Experimental Example 2, the throat composition having a good voice improvement action satisfies the above formula (I) in the water-soluble solid content and potassium ion concentration of black beans. Therefore, according to the prescriptions shown in Tables 9 and 10, a liquid throat composition (black bean syrup) satisfying such conditions (Formulation Examples 14 and 15) and a solid throat composition (Coolable Type: Formulation Example 16, A troche type: Formulation Example 17) was prepared, and the voice improvement effect was evaluated according to the voice improvement feeling evaluation test described in Experimental Example 1. The results are shown in Tables 9 and 10.

 [0136] (1) Formulation examples 14 to 15 (liquid throat composition)

 Black beans extract (water-soluble solid content 70%) 57.2kg, K PO 2.1kg, water 939.7kg,

 3 4

 After dissolving by heating and stirring at 80 ° C, add 1 kg of fragrance, sterilize by autoclave at 121 ° C for 20 min, and add 1 kg of liquid throat composition of formulation example 14 with viscosity 3 mPa 's pH 7.64 Prepared. In addition, the liquid throat composition (pH 6) in Formulation Example 14 was replaced with K PO1

 3 4

 It was prepared in the same manner as the composition of Formulation Example 14 except that

[0137] [Table 9]

 [0138] (2) Formulation Examples 16 to 17 (solid throat composition)

Ingredients other than fragrance are mixed according to the formulation described in Table 10, granulated with a fluid bed granulator, then fragrance is added and mixed uniformly, and tableted with a rotary tableting machine (rotation speed 20 rpm). did. Thus to heal Abul type m ² N hardness 10 kg (Formulation Example 16) could be obtained two tablets (one grain 0.9 g) of the lozenge type N hardness 19 kg m ² (Formulation Example 17).

 [0139] The black bean extract FD powder was prepared as follows:

First, a black bean concentrate extract (water-soluble solid content 20%) was prepared, and 140 kg of the extract was freeze-dried at _0.8ΤΤΓΓ or lower for 24 hours and crushed into blocks. After that, 30.5 kg of black bean extract FD powder was obtained by passing through a 30 mesh sieve.

 [0140] When the two types of tablets thus prepared were subjected to a voice improvement feeling evaluation test, one tablet (0.9 g) of tuple can be melted with about 1 lg of saliva, and one tablet of troche (0.9 g) g) could be licked and dissolved with about 5g of saliva. The oral pH at this time was pH 6.62 and 7.10, respectively.

[0141] [Table 10] Formulation Example 16 Formulation Example 17 Raw Material

 (Chiable type) (Troach type) Black bean extract FD powder 175 350

 Glucose 491 606 and P3 300

 KC I 3 13

 Sucrose fatty acid ester 30 30

 Fragrance 1 1

 Mouth BT 1000 1000

Hardness (kg / cm ² ) 10 19 Voice improvement effect 22 18 Brief description of drawings

FIG. 1 is a graph showing the relationship between the black bean water-soluble solid content (% by weight) contained in the throat composition of the present invention and the concentration (% by weight) of potassium ions derived from potassium inclusions. It is a figure when the upper limit of the vertical axis (black bean water-soluble solid content%) is 20% by weight and the upper limit of the horizontal axis (added potassium ion concentration%) is 1% by weight.

 FIG. 2 is a graph showing the relationship between the black bean water-soluble solid content (% by weight) contained in the throat composition of the present invention and the concentration (% by weight) of potassium ions derived from potassium-containing substances. It is a figure when the upper limit of the vertical axis (black bean water-soluble solid content%) is 70% by weight and the upper limit of the horizontal axis (added potassium ion concentration%) is 2% by weight.

Claims

The scope of the claims  [I] ¾i¾50-36,000 mPa-s (7) Liquid throat composition, comprising 4-20% by weight of water-soluble solid content of black beans.  [2] The liquid throat composition according to claim 1, comprising a solvent extract of black beans as an active ingredient. [3] The black bean solvent extract is obtained by enzymatic treatment of the black bean solvent extract. The liquid throat composition according to claim 2. [4] The liquid throat composition according to claim 1 or 2, further comprising a viscosity-imparting agent. [5] The viscosity-imparting agent is a polysaccharide consisting of locust bean gum, tamarind seed gum, pullulan, xanthan gum, guar gum, tara gum, rhamsan gum, mannan, inulin, and polydextrose, and molasses, honey, fructose glucose liquid sugar 5. The liquid throat composition according to claim 4, which is at least one selected from the group consisting of saccharides consisting of reduced maltose starch syrup, reduced starch hydrolyzate and starch syrup. 6. The liquid throat composition according to claim 1, wherein the pH is in the range of 5-9.  [7] Throat composition containing water-soluble solids of black beans and potassium-containing material in a proportion that satisfies the relationship of the following formula (I):  Country Y ≥ 0. 6 2 8 5 X- ^{0 7276} (I)  X: Potassium ion concentration (weight) derived from potassium content in the composition  Y: Black bean water-soluble solid content concentration in composition (wt%) (Y≥0.5 wt <½)  8. The throat composition according to claim 7, comprising a black bean solvent extract as an active ingredient. [9] The throat composition according to claim 7, wherein the black bean water-soluble solid concentration in the composition is 0.5 to 20% by weight.  [10] The throat composition according to claim 7, wherein the potassium ion concentration derived from the potassium-containing material in the composition is 0.0;! To 2% by weight.  [I I] The throat composition according to claim 7, which is a composition having a pH of 5 to 9 in the oral cavity.  [12] The throat composition according to claim 7, wherein the throat composition is a liquid composition, a semi-solid composition or a solid composition! /. [13] Solid throat composition power The throat composition according to claim 12, which is a chewable tablet, a troche, or a sputum. [14] A method for preventing or improving vocal dysfunction, comprising orally ingesting a throat composition according to any one of claims 1 to 13. [15] Use of the throat composition according to any one of claims 1 to 13 for the preparation of a dysphonia prevention agent or a dysphonia amelioration agent. [16] The throat composition according to any one of claims 1 to 13, which is used as a dysphonia preventive agent or a dysphonia improving agent.