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WO2008051994A3 - Fluid-conserving cascade hemofiltration - Google Patents

Fluid-conserving cascade hemofiltration Download PDF

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Publication number
WO2008051994A3
WO2008051994A3 PCT/US2007/082268 US2007082268W WO2008051994A3 WO 2008051994 A3 WO2008051994 A3 WO 2008051994A3 US 2007082268 W US2007082268 W US 2007082268W WO 2008051994 A3 WO2008051994 A3 WO 2008051994A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
output stream
reservoir
primary
enriched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/082268
Other languages
French (fr)
Other versions
WO2008051994A2 (en
Inventor
Jacek Rozga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARBIOS SYSTEMS Inc
Original Assignee
ARBIOS SYSTEMS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARBIOS SYSTEMS Inc filed Critical ARBIOS SYSTEMS Inc
Priority to JP2009534821A priority Critical patent/JP2010507464A/en
Priority to EP07854348A priority patent/EP2076297A2/en
Publication of WO2008051994A2 publication Critical patent/WO2008051994A2/en
Publication of WO2008051994A3 publication Critical patent/WO2008051994A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3479—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by dialysing the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)

Abstract

Methods and apparatus efficiently purify blood or blood-derived fluid in a manner that reduces wasted fluid. A blood purification apparatus has a primary purification device and receives, at an input via a primary inlet line, a primary input fluid from a fluid source. The primary purification device partitions the input fluid into two output streams. The first output stream is enriched in larger components and the second output stream is enriched in smaller components. The first output stream is returnable to the source via a primary outlet line. A reservoir stores reservoir fluid and is positioned to accept the second output stream. A secondary purification device coupled to the reservoir receives reservoir fluid from the reservoir and partitions the reservoir fluid into two further streams: a third output stream enriched in larger components and a fourth output stream enriched in smaller components. The fourth output stream is coupled to merge with either the primary inlet line or to the first output stream. The third output stream is coupled to the reservoir. As a result, albumin or other intermediate weight molecules concentrates in the reservoir over time. Optionally, the apparatus may include a dialysis or adsorption module for removing low molecular weight toxins.
PCT/US2007/082268 2006-10-23 2007-10-23 Fluid-conserving cascade hemofiltration Ceased WO2008051994A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009534821A JP2010507464A (en) 2006-10-23 2007-10-23 Liquid-saving cascade hemofiltration
EP07854348A EP2076297A2 (en) 2006-10-23 2007-10-23 Fluid-conserving cascade hemofiltration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86250806P 2006-10-23 2006-10-23
US60/862,508 2006-10-23

Publications (2)

Publication Number Publication Date
WO2008051994A2 WO2008051994A2 (en) 2008-05-02
WO2008051994A3 true WO2008051994A3 (en) 2008-07-10

Family

ID=39284248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/082268 Ceased WO2008051994A2 (en) 2006-10-23 2007-10-23 Fluid-conserving cascade hemofiltration

Country Status (3)

Country Link
EP (1) EP2076297A2 (en)
JP (1) JP2010507464A (en)
WO (1) WO2008051994A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2606921A1 (en) * 2011-12-21 2013-06-26 Infomed SA Device for purifying blood by extracorporeal circulation
WO2013103906A1 (en) * 2012-01-04 2013-07-11 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
DE102012025164A1 (en) * 2012-12-21 2014-06-26 Fresenius Medical Care Deutschland Gmbh Apparatus for removing protein-bound toxins from blood plasma
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
ITMI20131250A1 (en) * 2013-07-25 2015-01-25 Warsaw Medical University BLOOD PURIFICATION SYSTEMS AND DEVICES WITH INTERNALLY GENERATED REPLACEMENT FLUID
CA2957011C (en) * 2014-04-17 2023-04-25 ImMutriX Therapeutics, Inc. Therapeutic detoxification compositions and methods of making and using same
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US11278654B2 (en) 2017-12-07 2022-03-22 Medtronic, Inc. Pneumatic manifold for a dialysis system
CN108211032B (en) 2018-02-01 2023-11-17 南方医科大学珠江医院 Combined bioartificial liver support system
US11033667B2 (en) 2018-02-02 2021-06-15 Medtronic, Inc. Sorbent manifold for a dialysis system
US11110215B2 (en) 2018-02-23 2021-09-07 Medtronic, Inc. Degasser and vent manifolds for dialysis
US12128165B2 (en) 2020-04-27 2024-10-29 Mozarc Medical Us Llc Dual stage degasser

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2017473A1 (en) * 1970-04-11 1971-10-28 Sartorius-Membranfilter GmbH, 3400 Göttingen Device for dialysis of human blood
WO1984000112A1 (en) * 1982-06-23 1984-01-19 Nor Tron As Apparatus for separating from a biological liquid, in particular blood, a fraction having molecular weight between an upper and lower limiting value
EP0232884A2 (en) * 1986-02-10 1987-08-19 Millipore Corporation Diafiltration apparatus
WO1996028198A1 (en) * 1995-03-13 1996-09-19 Ao Forschungsinstitut Davos An extracorporeal blood treatment apparatus and method for removal of free circulating infectious agents
EP0990444A2 (en) * 1998-09-14 2000-04-05 American Immuno Tech, LLC Septicemia prevention and treatment system
WO2004091694A1 (en) * 2003-04-16 2004-10-28 Federico Nalesso Machine for plasma purification combined with plasma adsorption-perfusion by using a tricompartmental dialyzer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO160487C (en) * 1986-11-26 1989-04-26 Fasting Biotech As DEVICE FOR CYOGLOBULIN REMOVAL.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2017473A1 (en) * 1970-04-11 1971-10-28 Sartorius-Membranfilter GmbH, 3400 Göttingen Device for dialysis of human blood
WO1984000112A1 (en) * 1982-06-23 1984-01-19 Nor Tron As Apparatus for separating from a biological liquid, in particular blood, a fraction having molecular weight between an upper and lower limiting value
EP0232884A2 (en) * 1986-02-10 1987-08-19 Millipore Corporation Diafiltration apparatus
WO1996028198A1 (en) * 1995-03-13 1996-09-19 Ao Forschungsinstitut Davos An extracorporeal blood treatment apparatus and method for removal of free circulating infectious agents
EP0990444A2 (en) * 1998-09-14 2000-04-05 American Immuno Tech, LLC Septicemia prevention and treatment system
WO2004091694A1 (en) * 2003-04-16 2004-10-28 Federico Nalesso Machine for plasma purification combined with plasma adsorption-perfusion by using a tricompartmental dialyzer

Also Published As

Publication number Publication date
JP2010507464A (en) 2010-03-11
WO2008051994A2 (en) 2008-05-02
EP2076297A2 (en) 2009-07-08

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