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WO2008049997A3 - Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2008049997A3
WO2008049997A3 PCT/FR2007/001708 FR2007001708W WO2008049997A3 WO 2008049997 A3 WO2008049997 A3 WO 2008049997A3 FR 2007001708 W FR2007001708 W FR 2007001708W WO 2008049997 A3 WO2008049997 A3 WO 2008049997A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
indole derivatives
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/001708
Other languages
English (en)
Other versions
WO2008049997A2 (fr
WO2008049997A8 (fr
Inventor
Pascal Marchand
Vincent Badonneau
Sylvie Piessard
Muriel Duflos
Jean Albert Boutin
Valerie Audinot
Philippe Delagrange
Daniel-Henri Gaignard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002666522A priority Critical patent/CA2666522A1/fr
Priority to US12/311,805 priority patent/US20100204276A1/en
Priority to JP2009532844A priority patent/JP2010506890A/ja
Priority to BRPI0717528-0A priority patent/BRPI0717528A2/pt
Priority to AU2007310770A priority patent/AU2007310770A1/en
Priority to EP07858468A priority patent/EP2079689A2/fr
Priority to EA200900481A priority patent/EA200900481A1/ru
Priority to MX2009004006A priority patent/MX2009004006A/es
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of WO2008049997A2 publication Critical patent/WO2008049997A2/fr
Publication of WO2008049997A3 publication Critical patent/WO2008049997A3/fr
Anticipated expiration legal-status Critical
Priority to NO20091779A priority patent/NO20091779L/no
Publication of WO2008049997A8 publication Critical patent/WO2008049997A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Composés de formule (I) : dans laquelle : R1 représente un groupement alkyle, cycloalkyle ou cycloalkylalkyle, R2 et R3 forment ensemble avec l'atome d'azote qui les porte un hétérocycle comportant de 5 à 8 chaînons, et n représente 2 à 6, médicaments.
PCT/FR2007/001708 2006-10-18 2007-10-17 Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Ceased WO2008049997A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EA200900481A EA200900481A1 (ru) 2006-10-18 2007-10-17 Новые соединения индола, способ их получения и фармацевтические композиции, которые их содержат
JP2009532844A JP2010506890A (ja) 2006-10-18 2007-10-17 インドール誘導体、その製造法、およびそれを含有する薬学的組成物
BRPI0717528-0A BRPI0717528A2 (pt) 2006-10-18 2007-10-17 Derivados indólicos, seu processo de preparação e as composições farmacêuticas que os contêm
AU2007310770A AU2007310770A1 (en) 2006-10-18 2007-10-17 New indole compounds, a process for their preparation and pharmaceutical compositions containing them
EP07858468A EP2079689A2 (fr) 2006-10-18 2007-10-17 Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA002666522A CA2666522A1 (fr) 2006-10-18 2007-10-17 Nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US12/311,805 US20100204276A1 (en) 2006-10-18 2007-10-17 Indole compounds, a process for their preparation and pharmaceutical compositions containing them
MX2009004006A MX2009004006A (es) 2006-10-18 2007-10-17 Derivados de indol novedosos, proceso para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
NO20091779A NO20091779L (no) 2006-10-18 2009-05-06 Nye indolforbindelser en prosess for deres fremstilling og farmasoytiske sammensetninger som inneholder dem

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609113 2006-10-18
FR0609113A FR2907451B1 (fr) 2006-10-18 2006-10-18 "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"

Publications (3)

Publication Number Publication Date
WO2008049997A2 WO2008049997A2 (fr) 2008-05-02
WO2008049997A3 true WO2008049997A3 (fr) 2008-09-12
WO2008049997A8 WO2008049997A8 (fr) 2009-05-22

Family

ID=38051392

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001708 Ceased WO2008049997A2 (fr) 2006-10-18 2007-10-17 Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US20100204276A1 (fr)
EP (1) EP2079689A2 (fr)
JP (1) JP2010506890A (fr)
KR (1) KR20090084874A (fr)
CN (1) CN101522616A (fr)
AR (1) AR063328A1 (fr)
AU (1) AU2007310770A1 (fr)
BR (1) BRPI0717528A2 (fr)
CA (1) CA2666522A1 (fr)
EA (1) EA200900481A1 (fr)
FR (1) FR2907451B1 (fr)
GE (1) GEP20115240B (fr)
MA (1) MA30797B1 (fr)
MX (1) MX2009004006A (fr)
NO (1) NO20091779L (fr)
UA (1) UA91645C2 (fr)
WO (1) WO2008049997A2 (fr)
ZA (1) ZA200902414B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5758395B2 (ja) 2009-10-15 2015-08-05 ザ チルドレンズ メディカル センター コーポレイション 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬
CN103601683B (zh) * 2010-04-16 2016-03-30 中国科学院上海药物研究所 苯并杂环类化合物及其制备方法和用途
RU2016133277A (ru) 2014-01-14 2018-02-19 Астеллас Фарма Инк. C0единение индола
CN105085366A (zh) * 2014-05-07 2015-11-25 北京生命科学研究所 一种吲哚骨架化合物及其应用
CN108299274B (zh) * 2018-02-08 2021-01-15 中国热带农业科学院海口实验站 一种天然吲哚，其制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006140A1 (fr) * 1995-08-08 1997-02-20 Cemaf Derives acyles de la melatonine et d'analogues en tant que medicament

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006140A1 (fr) * 1995-08-08 1997-02-20 Cemaf Derives acyles de la melatonine et d'analogues en tant que medicament

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GILBERTO SPADONI ET AL.: "Towards the development of mixed MT1-Agonist/MT2-Antagonist melatonin receptor ligands", CHEMMEDCHEM, vol. 1, 6 September 2006 (2006-09-06), WEINHEIM DE, pages 1099 - 1105, XP008079439 *
PEREZ MICHEL ET AL.: "Synthesis and structure-activity relationships of 5-substituted tryptamine derivatives of o-tolylpiperazine as agonists at 5-HT1D receptors", MEDICINAL CHEMISTRY RESEARCH., vol. 5, no. 9, 1995, USBIRKHAEUSER, BOSTON., pages 680 - 689, XP008079435 *

Also Published As

Publication number Publication date
BRPI0717528A2 (pt) 2013-10-22
AR063328A1 (es) 2009-01-21
FR2907451B1 (fr) 2008-12-12
UA91645C2 (ru) 2010-08-10
EA200900481A1 (ru) 2009-10-30
KR20090084874A (ko) 2009-08-05
US20100204276A1 (en) 2010-08-12
CA2666522A1 (fr) 2008-05-02
EP2079689A2 (fr) 2009-07-22
JP2010506890A (ja) 2010-03-04
GEP20115240B (en) 2011-06-10
WO2008049997A2 (fr) 2008-05-02
MX2009004006A (es) 2009-04-28
MA30797B1 (fr) 2009-10-01
AU2007310770A1 (en) 2008-05-02
ZA200902414B (en) 2010-07-28
CN101522616A (zh) 2009-09-02
WO2008049997A8 (fr) 2009-05-22
NO20091779L (no) 2009-05-06
FR2907451A1 (fr) 2008-04-25

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