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WO2007127011A2 - Appareil et procédé de filtrage destinés à améliorer la détection de pics - Google Patents

Appareil et procédé de filtrage destinés à améliorer la détection de pics Download PDF

Info

Publication number
WO2007127011A2
WO2007127011A2 PCT/US2007/007855 US2007007855W WO2007127011A2 WO 2007127011 A2 WO2007127011 A2 WO 2007127011A2 US 2007007855 W US2007007855 W US 2007007855W WO 2007127011 A2 WO2007127011 A2 WO 2007127011A2
Authority
WO
WIPO (PCT)
Prior art keywords
hole array
samples
array filter
layer
filtered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/007855
Other languages
English (en)
Other versions
WO2007127011A3 (fr
Inventor
Chulso Moon
Atsushi Takano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dai Nippon Printing Co Ltd
Cangen Biotechnologies Inc
Original Assignee
Dai Nippon Printing Co Ltd
Cangen Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/391,469 external-priority patent/US20070238193A1/en
Priority claimed from US11/391,471 external-priority patent/US20070231917A1/en
Priority claimed from US11/391,182 external-priority patent/US20070231915A1/en
Priority claimed from US11/391,183 external-priority patent/US20070231916A1/en
Application filed by Dai Nippon Printing Co Ltd, Cangen Biotechnologies Inc filed Critical Dai Nippon Printing Co Ltd
Priority to JP2009503017A priority Critical patent/JP2009531716A/ja
Priority to EP07754381A priority patent/EP2013800A2/fr
Priority to US12/225,704 priority patent/US20100140465A1/en
Publication of WO2007127011A2 publication Critical patent/WO2007127011A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007127011A3 publication Critical patent/WO2007127011A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/575—
    • G01N33/5752—
    • G01N33/57525—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Definitions

  • the use of the filter accentuated the differences between the presence of peaks in. the pre-filter and post-filter chromatograms for pancreatic cancer. These results will be apparent to one of ordinary skill in the art by examining FIGS. 7-1 to 7-42 in the same manner as the examination of the results of the lung cancer screening discussed above. Clearly, the use of the filter enhanced the detection of the relevant peaks.
  • nucleic acid complexes protein-DNA complexes, receptor-ligand complexes, enzyme-substrate, enzyme inhibitors, peptide complexes, protein complexes, carbohydrate complexes, and polysaccharide complexes
  • small biological molecules such as amino acids, nucleotides, nucleosides, sugars, steroids, lipids, metal ions, drugs, hormones, amides, amines, carboxylic acids, vitamins and coenzymes, alcohols, aldehydes, ketones, fatty acids, porphyrins, carotenoids, plant growth regulators, phosphate esters and nucleoside diphospho-sugars, synthetic small molecules such as pharmaceutically or therapeutically effective agents, monomers, peptide analogs, steroid analogs, inhibitors, mutagens, carcinogens, antimitotic drugs, antibiotics, ionophores, antimetabolites, amino acid analogs, antibacterial agents, transport inhibitors, surface-active agents (surfactants), mitochondrial and
  • the serum was diluted 1 : 10 in 0.1% n-Octyl ⁇ -D- Glucopyranoside.
  • the micro tubes were cut individually from Micro Amp 8 strip tubes. A hole was made in the bottom part of the micro tube by using a needle (Becton Dickinson 20Gl) having a diameter of 0.9 mm or less.
  • the micro tube with hole was placed on the metal plate of a gel-pak suction apparatus (air pump) and the hole was adjusted to the same air-flow direction of the air pump.
  • the filter was placed on the top of the micro tube. 20 ⁇ l of serum was loaded on the upper part of filter. The serum solution spread out, filling the inner square of filter. The negative air flow was applied by pumping the air pump manually.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

L'invention concerne des filtres et des procédés destinés à améliorer l'identification de pics dans des données de spectroscopie de masse. Plus particulièrement, l'invention concerne des procédés qui utilisent des filtres de réseau d'orifices destinés à purifier des fluides biologiques utilisés dans la production de données de spectre de masse. Les procédés de l'invention peuvent être utilisés en vue d'améliorer les pics importants dans des données de spectre de masse utiles dans l'identification et le diagnostic de maladies ou dans la prédication des réactions à des traitements particuliers.
PCT/US2007/007855 2006-03-29 2007-03-29 Appareil et procédé de filtrage destinés à améliorer la détection de pics Ceased WO2007127011A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009503017A JP2009531716A (ja) 2006-03-29 2007-03-29 ピークの検出を向上させる濾過器具および方法
EP07754381A EP2013800A2 (fr) 2006-03-29 2007-03-29 Appareil et procédé de filtrage destinés à améliorer la détection de pics
US12/225,704 US20100140465A1 (en) 2006-03-29 2007-03-29 Apparatus and Method for Filtration to Enhance the Detection of Peaks

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11/391,183 2006-03-29
US11/391,469 US20070238193A1 (en) 2006-03-29 2006-03-29 Apparatus and method for filtration to enhance the detection of peaks
US11/391,471 US20070231917A1 (en) 2006-03-29 2006-03-29 Apparatus and method for filtration to enhance the detection of peaks
US11/391,182 US20070231915A1 (en) 2006-03-29 2006-03-29 Apparatus and method for filtration to enhance the detection of peaks
US11/391,182 2006-03-29
US11/391,183 US20070231916A1 (en) 2006-03-29 2006-03-29 Apparatus and method for filtration to enhance the detection of peaks
US11/391,471 2006-03-29
US11/391,469 2006-03-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/441,239 A-371-Of-International US8192503B2 (en) 2006-09-15 2007-09-14 Method and apparatus for decreasing build height of prosthetic products
US13/480,193 Division US8992630B2 (en) 2006-09-15 2012-05-24 Method and apparatus for decreasing build height of prosthetic products

Publications (2)

Publication Number Publication Date
WO2007127011A2 true WO2007127011A2 (fr) 2007-11-08
WO2007127011A3 WO2007127011A3 (fr) 2008-12-04

Family

ID=38656080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/007855 Ceased WO2007127011A2 (fr) 2006-03-29 2007-03-29 Appareil et procédé de filtrage destinés à améliorer la détection de pics

Country Status (4)

Country Link
EP (1) EP2013800A2 (fr)
JP (1) JP2009531716A (fr)
KR (1) KR20090028684A (fr)
WO (1) WO2007127011A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2623984A1 (fr) * 2012-01-03 2013-08-07 National Cancer Center Appareil pour le dépistage du cancer
US10042983B2 (en) 2012-01-03 2018-08-07 National Cancer Center Apparatus for cancer diagnosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
GB0122200D0 (en) * 2001-09-14 2001-10-31 James Peter Concentration of protein and/or peptide samples
JP2006524502A (ja) * 2003-02-28 2006-11-02 バイエル・フアーマシユーチカルズ・コーポレーシヨン 乳癌の発現プロファイル及び使用法
EP1676292A4 (fr) * 2003-10-10 2009-01-07 Protein Discovery Inc Procedes et dispositifs pour concentration et epuration d'analytes en vue d'une analyse chimique incluant une spectrometrie de masse (ms) a desorption-ionisation par impact laser assistee par matrice (maldi)
JP2005156249A (ja) * 2003-11-21 2005-06-16 Toray Ind Inc 生体成分分離溶液
EP1866055A4 (fr) * 2005-04-05 2010-08-18 Protein Discovery Inc Procedes et dispositifs ameliores de concentration et de fractionnement de substances a analyser aux fins d'analyse chimique, notamment par spectrometrie de masse (ms) a desorption-ionisation par impact laser assistee par matrice (maldi)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2623984A1 (fr) * 2012-01-03 2013-08-07 National Cancer Center Appareil pour le dépistage du cancer
US10042983B2 (en) 2012-01-03 2018-08-07 National Cancer Center Apparatus for cancer diagnosis

Also Published As

Publication number Publication date
JP2009531716A (ja) 2009-09-03
WO2007127011A3 (fr) 2008-12-04
EP2013800A2 (fr) 2009-01-14
KR20090028684A (ko) 2009-03-19

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