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WO2007100351A3 - Procede de preparation de la simvastatine et associes produits intermediaires - Google Patents

Procede de preparation de la simvastatine et associes produits intermediaires Download PDF

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Publication number
WO2007100351A3
WO2007100351A3 PCT/US2006/035824 US2006035824W WO2007100351A3 WO 2007100351 A3 WO2007100351 A3 WO 2007100351A3 US 2006035824 W US2006035824 W US 2006035824W WO 2007100351 A3 WO2007100351 A3 WO 2007100351A3
Authority
WO
WIPO (PCT)
Prior art keywords
simvastatin
intermediates
preparation
lovastatin
amide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/035824
Other languages
English (en)
Other versions
WO2007100351A2 (fr
Inventor
Ferenc Korodi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Works PLC
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Works PLC, Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Works PLC
Priority to EP06814653A priority Critical patent/EP1883634A2/fr
Priority to CA002619236A priority patent/CA2619236A1/fr
Publication of WO2007100351A2 publication Critical patent/WO2007100351A2/fr
Publication of WO2007100351A3 publication Critical patent/WO2007100351A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux processus de préparation de la simvastatine et les produits intermédiaires intervenant au cours de ces processus. Les modes de réalisation préférés comprennent la préparation des amides lovastatine, des dérivés d'amide protégés de la lovastatine, des dérivés d'amide d'acides dihydroxy de la simvastatine, des sels alcalins, des acides dihydroxy de la simvastatine, des sels d'ammonium de la simvastatine, et enfin de la simvastatine.
PCT/US2006/035824 2005-09-13 2006-09-13 Procede de preparation de la simvastatine et associes produits intermediaires Ceased WO2007100351A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06814653A EP1883634A2 (fr) 2005-09-13 2006-09-13 Procede de preparation de la simvastatine et associes produits intermediaires
CA002619236A CA2619236A1 (fr) 2005-09-13 2006-09-13 Procede de preparation de la simvastatine et associes produits intermediaires

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71700605P 2005-09-13 2005-09-13
US60/717,006 2005-09-13
US74254105P 2005-12-06 2005-12-06
US60/742,541 2005-12-06

Publications (2)

Publication Number Publication Date
WO2007100351A2 WO2007100351A2 (fr) 2007-09-07
WO2007100351A3 true WO2007100351A3 (fr) 2007-12-06

Family

ID=37898832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/035824 Ceased WO2007100351A2 (fr) 2005-09-13 2006-09-13 Procede de preparation de la simvastatine et associes produits intermediaires

Country Status (4)

Country Link
EP (1) EP1883634A2 (fr)
KR (1) KR20080034190A (fr)
CA (1) CA2619236A1 (fr)
WO (1) WO2007100351A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027872T2 (en) 2006-05-03 2016-11-28 Msn Laboratories Private Ltd A novel process for statins and their pharmaceutically acceptable salts
ES2567171T3 (es) * 2006-10-09 2016-04-20 Msn Laboratories Private Limited Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables
EP2387561A4 (fr) 2009-01-19 2012-07-25 Msn Lab Ltd Procédé amélioré d'élaboration d'acide (3r,5s)-7-ý2-cyclopropyl-4-(4-fluorophényl)quinolin-3-yl¨-3,5-dihydroxy-6(e)-heptènoïque de haute pureté, y compris ses sels pharmaceutiquement acceptables
US8252829B2 (en) 2009-06-05 2012-08-28 Link Medicine Corporation Aminopyrrolidinone derivatives and uses thereof
WO2011086584A2 (fr) 2010-01-18 2011-07-21 Msn Laboratories Limited Procédé amélioré pour la préparation d'intermédiaires amides et leur utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
WO2003045935A1 (fr) * 2001-11-29 2003-06-05 Fermic S.A. De C.V. Procede d'alkylation du carbone alpha de la chaine secondaire de 2-methylbutyrate de lovastatine
WO2005066150A1 (fr) * 2004-01-02 2005-07-21 Hetero Drugs Limited Nouveau procede de preparation de simvastatine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
WO2003045935A1 (fr) * 2001-11-29 2003-06-05 Fermic S.A. De C.V. Procede d'alkylation du carbone alpha de la chaine secondaire de 2-methylbutyrate de lovastatine
WO2005066150A1 (fr) * 2004-01-02 2005-07-21 Hetero Drugs Limited Nouveau procede de preparation de simvastatine

Also Published As

Publication number Publication date
CA2619236A1 (fr) 2007-09-07
KR20080034190A (ko) 2008-04-18
EP1883634A2 (fr) 2008-02-06
WO2007100351A2 (fr) 2007-09-07

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