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WO2007038868A3 - Nouveau compose d'enediyne et ses utilisations - Google Patents

Nouveau compose d'enediyne et ses utilisations Download PDF

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Publication number
WO2007038868A3
WO2007038868A3 PCT/CA2006/001634 CA2006001634W WO2007038868A3 WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3 CA 2006001634 W CA2006001634 W CA 2006001634W WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
uncialamycin
methods
compound
kill
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2006/001634
Other languages
English (en)
Other versions
WO2007038868A2 (fr
Inventor
Julian E Davies
Raymond J Anderson
Hao Wang
Koaru Warabi
Xin Hui Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of WO2007038868A2 publication Critical patent/WO2007038868A2/fr
Publication of WO2007038868A3 publication Critical patent/WO2007038868A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un nouveau composé d'énédiyne, l'uncialamycine, et ses analogues. Elle concerne également des méthodes d'utilisation du composé pour traiter des infections bactériennes, inhiber la croissance bactérienne, et tuer des bactéries. Le composé de l'invention peut également être utilisé pour traiter des tumeurs, empêcher la croissance de cellules tumorales, tuer des cellules tumorales, traiter des cancers, empêcher la croissance de cellules cancéreuses, et tuer des cellules cancéreuses. L'invention concerne aussi des méthodes de production d'analogues d'uncialamycine. Elle concerne en outre des compositions comprenant l'uncialamycine et des méthodes d'administration des compositions de l'invention.
PCT/CA2006/001634 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations Ceased WO2007038868A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72240705P 2005-10-03 2005-10-03
US60/722,407 2005-10-03

Publications (2)

Publication Number Publication Date
WO2007038868A2 WO2007038868A2 (fr) 2007-04-12
WO2007038868A3 true WO2007038868A3 (fr) 2007-11-08

Family

ID=37906518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2006/001634 Ceased WO2007038868A2 (fr) 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations

Country Status (1)

Country Link
WO (1) WO2007038868A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013221873B2 (en) * 2012-02-13 2016-11-17 Bristol-Myers Squibb Company Enediyne compounds, conjugates thereof, and uses and methods therefor
AU2014306592B2 (en) 2013-08-14 2019-04-04 Bristol-Myers Squibb Company Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
AU2015231210B2 (en) 2014-03-20 2019-09-12 Bristol-Myers Squibb Company Stabilized fibronectin based scaffold molecules
KR102569813B1 (ko) 2014-11-21 2023-08-24 브리스톨-마이어스 스큅 컴퍼니 Cd73에 대항한 항체 및 그의 용도
CN113929770A (zh) 2014-11-21 2022-01-14 百时美施贵宝公司 包含修饰的重链恒定区的抗体
WO2016086021A1 (fr) 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Nouveaux polypeptides fixant pd-l1 pour l'imagerie
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
CN107406496A (zh) 2015-03-10 2017-11-28 百时美施贵宝公司 可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物
PT3303396T (pt) 2015-05-29 2023-01-30 Bristol Myers Squibb Co Anticorpos contra ox40 e utilizações dos mesmos
CN108025071B (zh) * 2015-09-17 2022-11-01 斯克利普斯研究院 双重可变结构域免疫缀合物及其用途
CN108884147B (zh) 2015-09-23 2024-02-27 百时美施贵宝公司 结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子
MX2018007479A (es) 2015-12-21 2018-08-01 Squibb Bristol Myers Co Anticuerpos variantes para conjugacion especifica de sitio.
US20190284293A1 (en) 2016-03-04 2019-09-19 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
US20190218294A1 (en) 2016-09-09 2019-07-18 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
SG10201913206RA (en) 2017-05-25 2020-02-27 Bristol Myers Squibb Co Antibodies comprising modified heavy constant regions
KR20210096167A (ko) 2018-11-28 2021-08-04 브리스톨-마이어스 스큅 컴퍼니 변형된 중쇄 불변 영역을 포함하는 항체
SMT202300159T1 (it) 2018-11-30 2023-07-20 Bristol Myers Squibb Co Anticorpo comprendente un’estensione carbossiterminale della catena leggera contenente glutammina, suoi coniugati e metodi ed usi
EP3894443A2 (fr) 2018-12-12 2021-10-20 Bristol-Myers Squibb Company Anticorps modifiés pour la conjugaison de la transglutaminase, conjugués associés, et méthodes et utilisations
US20240377413A1 (en) 2019-09-16 2024-11-14 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
CN116813627B (zh) * 2023-06-15 2025-08-12 哈药慈航制药股份有限公司 一种天赐霉素类似物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVIES ET AL.: "UNCIALAMYCIN, A NEW ENEDIYNE ANTIBIOTIC", ORGANIC LETTERS, vol. 7, no. 23, 13 October 2005 (2005-10-13), pages 5233 - 5236, XP055154051, DOI: doi:10.1021/ol052081f *

Also Published As

Publication number Publication date
WO2007038868A2 (fr) 2007-04-12

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