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WO2007038868A3 - Nouveau compose d'enediyne et ses utilisations - Google Patents

Nouveau compose d'enediyne et ses utilisations Download PDF

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Publication number
WO2007038868A3
WO2007038868A3 PCT/CA2006/001634 CA2006001634W WO2007038868A3 WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3 CA 2006001634 W CA2006001634 W CA 2006001634W WO 2007038868 A3 WO2007038868 A3 WO 2007038868A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
uncialamycin
methods
compound
kill
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2006/001634
Other languages
English (en)
Other versions
WO2007038868A2 (fr
Inventor
Julian E Davies
Raymond J Anderson
Hao Wang
Koaru Warabi
Xin Hui Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of WO2007038868A2 publication Critical patent/WO2007038868A2/fr
Publication of WO2007038868A3 publication Critical patent/WO2007038868A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un nouveau composé d'énédiyne, l'uncialamycine, et ses analogues. Elle concerne également des méthodes d'utilisation du composé pour traiter des infections bactériennes, inhiber la croissance bactérienne, et tuer des bactéries. Le composé de l'invention peut également être utilisé pour traiter des tumeurs, empêcher la croissance de cellules tumorales, tuer des cellules tumorales, traiter des cancers, empêcher la croissance de cellules cancéreuses, et tuer des cellules cancéreuses. L'invention concerne aussi des méthodes de production d'analogues d'uncialamycine. Elle concerne en outre des compositions comprenant l'uncialamycine et des méthodes d'administration des compositions de l'invention.
PCT/CA2006/001634 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations Ceased WO2007038868A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72240705P 2005-10-03 2005-10-03
US60/722,407 2005-10-03

Publications (2)

Publication Number Publication Date
WO2007038868A2 WO2007038868A2 (fr) 2007-04-12
WO2007038868A3 true WO2007038868A3 (fr) 2007-11-08

Family

ID=37906518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2006/001634 Ceased WO2007038868A2 (fr) 2005-10-03 2006-10-03 Nouveau compose d'enediyne et ses utilisations

Country Status (1)

Country Link
WO (1) WO2007038868A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1204326A1 (en) * 2012-02-13 2015-11-13 Bristol-Myers Squibb Company Enediyne compounds, conjugates thereof, and uses and methods therefor
SG10201810067YA (en) 2013-08-14 2018-12-28 Univ Rice William M Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
EP3647322B1 (fr) 2014-03-20 2021-10-20 Bristol-Myers Squibb Company Molécules de charpente à base de fibronectine stabilisée
MX383868B (es) 2014-11-21 2025-03-14 Bristol Myers Squibb Co Anticuerpos contra cd73 y sus usos.
SMT202000579T1 (it) 2014-11-21 2020-11-10 Bristol Myers Squibb Co Anticorpi comprendenti regioni costanti pesanti modificate
EP3702367B1 (fr) 2014-11-25 2024-05-15 Bristol-Myers Squibb Company Nouveaux polypeptides de liaison pd-l1 pour imagerie
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
CN107406496A (zh) 2015-03-10 2017-11-28 百时美施贵宝公司 可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物
HRP20230060T1 (hr) 2015-05-29 2023-03-17 Bristol-Myers Squibb Company Antitijela protiv ox40 i njihova primjena
EP3349795B1 (fr) * 2015-09-17 2021-03-17 The Scripps Research Institute Immunoconjugués à double domaine variable et leurs utilisations
US10584160B2 (en) 2015-09-23 2020-03-10 Bristol-Myers Squibb Company Glypican-3-binding fibronectin based scaffold molecules
CN108431034A (zh) 2015-12-21 2018-08-21 百时美施贵宝公司 用于位点-特异性缀合的变体抗体
JP2019514844A (ja) 2016-03-04 2019-06-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｃｄ７３抗体を用いた併用療法
WO2018048975A1 (fr) 2016-09-09 2018-03-15 Bristol-Myers Squibb Company Utilisation d'un anticorps anti-pd-1 en combinaison avec un anticorps anti-mésothéline dans le traitement du cancer
EP4098662A1 (fr) 2017-05-25 2022-12-07 Bristol-Myers Squibb Company Anticorps comprenant des régions constantes de chaîne lourde modifiées
EP3887397A1 (fr) 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Anticorps comprenant des régions constantes de chaîne lourde modifiées
PL3886914T3 (pl) 2018-11-30 2023-05-08 Bristol-Myers Squibb Company Przeciwciało zawierające c-końcowe rozszerzenie łańcucha lekkiego zawierające glutaminę, jego koniugaty oraz metody i zastosowania
JP7514836B2 (ja) 2018-12-12 2024-07-11 ブリストル－マイヤーズ スクイブ カンパニー トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途
WO2021055306A1 (fr) 2019-09-16 2021-03-25 Bristol-Myers Squibb Company Méthode de capture double d'analyse de conjugués anticorps-médicament
CN116813627B (zh) * 2023-06-15 2025-08-12 哈药慈航制药股份有限公司 一种天赐霉素类似物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849750A (en) * 1994-07-27 1998-12-15 California Institute Of Technology Dynemicin analogs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVIES ET AL.: "UNCIALAMYCIN, A NEW ENEDIYNE ANTIBIOTIC", ORGANIC LETTERS, vol. 7, no. 23, 13 October 2005 (2005-10-13), pages 5233 - 5236, XP055154051, DOI: doi:10.1021/ol052081f *

Also Published As

Publication number Publication date
WO2007038868A2 (fr) 2007-04-12

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