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WO2007030792A3 - Reactifs pour la detection de la phosphorylation proteique dans des voies de signalisation de lymphome anaplasique a grandes cellules - Google Patents

Reactifs pour la detection de la phosphorylation proteique dans des voies de signalisation de lymphome anaplasique a grandes cellules Download PDF

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Publication number
WO2007030792A3
WO2007030792A3 PCT/US2006/035203 US2006035203W WO2007030792A3 WO 2007030792 A3 WO2007030792 A3 WO 2007030792A3 US 2006035203 W US2006035203 W US 2006035203W WO 2007030792 A3 WO2007030792 A3 WO 2007030792A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
cell lymphoma
large cell
anaplastic large
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/035203
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English (en)
Other versions
WO2007030792A2 (fr
Inventor
Roberto Polakiewicz
Kimberly Lee
Charles Farnsworth
Ailan Guo
Albrecht Moritz
Eric Spek
Francesco Boccalatte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Signaling Technology Inc
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Priority to EP06803284A priority Critical patent/EP1929296A2/fr
Publication of WO2007030792A2 publication Critical patent/WO2007030792A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007030792A3 publication Critical patent/WO2007030792A3/fr
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne presque 219 nouveaux sites de phosphorylation identifiés dans des protéines de transduction de signaux et des voies sous-jacentes à un lymphome anaplasique à grandes cellules impliquant la translocation/fusion NPM-ALK, ainsi que des anticorps spécifiques de sites de phosphorylation et des peptides étiquetés avec des isotopes lourds (peptides AQUA) dans la détection sélective et la quantification de ces sites/protéines phosphorylés. Ladite invention a aussi trait à des méthodes d'utilisation desdits réactifs à de telles fins.
PCT/US2006/035203 2005-09-09 2006-09-08 Reactifs pour la detection de la phosphorylation proteique dans des voies de signalisation de lymphome anaplasique a grandes cellules Ceased WO2007030792A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06803284A EP1929296A2 (fr) 2005-09-09 2006-09-08 Reactifs pour la detection de la phosphorylation proteique dans des voies de signalisation de lymphome anaplasique a grandes cellules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71582305P 2005-09-09 2005-09-09
US60/715,823 2005-09-09

Publications (2)

Publication Number Publication Date
WO2007030792A2 WO2007030792A2 (fr) 2007-03-15
WO2007030792A3 true WO2007030792A3 (fr) 2009-04-30

Family

ID=37836560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/035203 Ceased WO2007030792A2 (fr) 2005-09-09 2006-09-08 Reactifs pour la detection de la phosphorylation proteique dans des voies de signalisation de lymphome anaplasique a grandes cellules

Country Status (2)

Country Link
EP (1) EP1929296A2 (fr)
WO (1) WO2007030792A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160340659A1 (en) * 2014-01-30 2016-11-24 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRADY, W. A. ET AL.: "Cloning, characterization, and modeling of mouse and human guanylate kinases.", vol. 271, no. 28, 12 July 1996 (1996-07-12), pages 16,734 - 16,740 *
FITZGIBBON, J. ET AL.: "Human guanylate kinase (GUKI): cDNA sequence, expression and chromosomal localisation.", FEBS LETTERS., vol. 385, no. 3, 6 May 1996 (1996-05-06), pages 185 - 188, XP002204145, DOI: doi:10.1016/0014-5793(96)00365-1 *

Also Published As

Publication number Publication date
EP1929296A2 (fr) 2008-06-11
WO2007030792A2 (fr) 2007-03-15

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