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WO2007030580A3 - Agents neuroprotecteurs - Google Patents

Agents neuroprotecteurs Download PDF

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Publication number
WO2007030580A3
WO2007030580A3 PCT/US2006/034796 US2006034796W WO2007030580A3 WO 2007030580 A3 WO2007030580 A3 WO 2007030580A3 US 2006034796 W US2006034796 W US 2006034796W WO 2007030580 A3 WO2007030580 A3 WO 2007030580A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
neural
protecting
administering
excitotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/034796
Other languages
English (en)
Other versions
WO2007030580A2 (fr
Inventor
Mary Stenzel-Poore
Susan Stevens
Roger Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Original Assignee
Oregon Health and Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University filed Critical Oregon Health and Science University
Publication of WO2007030580A2 publication Critical patent/WO2007030580A2/fr
Publication of WO2007030580A3 publication Critical patent/WO2007030580A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés pour protéger des cellules contre des agressions cytotoxiques. Ces procédés consistent à administrer à un sujet une composition qui comprend un agent se liant à un récepteur de type Toll et activant ce dernier, puis éventuellement à administrer un inhibiteur des ASIC. Ces procédés peuvent s'appliquer pour protéger des cellules neurales et non neurales. Cette invention concerne par exemple des procédés pour protéger une cellule neurale contre une lésion cérébrale excitotoxique. Ladite invention concerne également des procédés pour préparer des médicaments utilisés pour traiter de manière prophylactique une lésion excitotoxique, une ischémie et/ou une hypoxie. En outre, cette invention concerne des compositions utilisées dans le cadre desdits procédés.
PCT/US2006/034796 2005-09-09 2006-09-08 Agents neuroprotecteurs Ceased WO2007030580A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71588105P 2005-09-09 2005-09-09
US60/715,881 2005-09-09
US80183006P 2006-05-19 2006-05-19
US60/801,830 2006-05-19

Publications (2)

Publication Number Publication Date
WO2007030580A2 WO2007030580A2 (fr) 2007-03-15
WO2007030580A3 true WO2007030580A3 (fr) 2007-10-11

Family

ID=37836442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034796 Ceased WO2007030580A2 (fr) 2005-09-09 2006-09-08 Agents neuroprotecteurs

Country Status (1)

Country Link
WO (1) WO2007030580A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100130425A1 (en) * 2005-09-09 2010-05-27 Oregon Health & Science University Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia
JP2010536907A (ja) 2007-08-31 2010-12-02 ニューリミューン セラピューティクス エイジー 患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法
WO2009105641A2 (fr) 2008-02-20 2009-08-27 New York University Prévention et traitement de dépôt de bêta-amyloïde par stimulation de l'immunité innée
EP2806028B1 (fr) 2008-11-04 2017-07-12 InDex Pharmaceuticals AB Composés et procédés de réduction du recrutement et/ou de la migration de cellules polymorphonucléaires
WO2016183371A1 (fr) 2015-05-13 2016-11-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Procédés pour le traitement ou la prévention d'une lésion tissulaire ischémique
WO2017011863A1 (fr) * 2015-07-17 2017-01-26 The University Of Queensland Agents neuroprotecteurs dérivés de peptides de venin d'araignée
WO2019140236A1 (fr) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Oligonucléotides antisens ciblant l'alpha-synucléine et leurs utilisations
SG11202006526YA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007743A2 (fr) * 2002-07-17 2004-01-22 Coley Pharmaceutical Gmbh Utilisation d'acides nucleiques cpg dans les maladies a prions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007743A2 (fr) * 2002-07-17 2004-01-22 Coley Pharmaceutical Gmbh Utilisation d'acides nucleiques cpg dans les maladies a prions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEN XUANMAO ET AL: "The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity", JOURNAL OF GENERAL PHYSIOLOGY, vol. 126, no. 1, July 2005 (2005-07-01), pages 71 - 79, XP002433748, ISSN: 0022-1295 *
XIONG ZHI-GANG ET AL: "Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels", CELL, vol. 118, no. 6, 17 September 2004 (2004-09-17), pages 687 - 698, XP002433749, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
WO2007030580A2 (fr) 2007-03-15

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