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WO2007015265A3 - A process for preparing 6,9-imino ether - Google Patents

A process for preparing 6,9-imino ether Download PDF

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Publication number
WO2007015265A3
WO2007015265A3 PCT/IN2006/000180 IN2006000180W WO2007015265A3 WO 2007015265 A3 WO2007015265 A3 WO 2007015265A3 IN 2006000180 W IN2006000180 W IN 2006000180W WO 2007015265 A3 WO2007015265 A3 WO 2007015265A3
Authority
WO
WIPO (PCT)
Prior art keywords
ether
erythromycin
lmino
preparing
imino ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2006/000180
Other languages
French (fr)
Other versions
WO2007015265A2 (en
Inventor
Mahajan Kiran Madhaorao
Patil Gokul Laxman
Chawan Mangesh Balwant
Hire Chandrabhan Madhav
Ambre Rajesh Viswanath
Randive Sachin Yashwant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kopran Research Laboratories Ltd
Original Assignee
Kopran Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kopran Research Laboratories Ltd filed Critical Kopran Research Laboratories Ltd
Publication of WO2007015265A2 publication Critical patent/WO2007015265A2/en
Anticipated expiration legal-status Critical
Publication of WO2007015265A3 publication Critical patent/WO2007015265A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

A process for preparing 6,9-lmino ether from Erythromycin thiocyanate without isolating Erythromycin base and Erythromycin oxime and Beckmann's rearrangement of erythromycin oxime is carried in the presence biphasic solvent system comprising methylene chloride and water in the presence of triethylamine along with sodium bicarbonate to obtain 87-96 % pure 6,9-lmino ether. Further the 6,9-lmino ether is hydrogenated to 9-Deoxo-9a-aza-9a-homoerythromycin A followed by reductive methylation to obtain Azithromycin dihydrate.
PCT/IN2006/000180 2005-05-24 2006-05-24 A process for preparing 6,9-imino ether Ceased WO2007015265A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN627/MUM/2005 2005-05-24
IN627MU2005 2005-05-24

Publications (2)

Publication Number Publication Date
WO2007015265A2 WO2007015265A2 (en) 2007-02-08
WO2007015265A3 true WO2007015265A3 (en) 2007-12-06

Family

ID=37709013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000180 Ceased WO2007015265A2 (en) 2005-05-24 2006-05-24 A process for preparing 6,9-imino ether

Country Status (1)

Country Link
WO (1) WO2007015265A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin
WO2009156938A2 (en) * 2008-06-24 2009-12-30 Alembic Limited A cost effective process for preparing 6,9-imino ether
US8106111B2 (en) 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
CN105481913B (en) * 2014-09-19 2019-01-08 宁夏启元药业有限公司 A method of synthesis azithromycin
CN106083954B (en) * 2016-06-22 2018-12-11 连云港笃翔化工有限公司 A kind of preparation method of 6,9 imines ether compound of erythromycin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
US20010047089A1 (en) * 2000-01-04 2001-11-29 Judith Aronhime Preparation method of azithromycin dihydrate
WO2002044193A1 (en) * 2000-11-30 2002-06-06 Ercros Industrial, S.A. Method for obtaining azaerythromycin
EP1469008A1 (en) * 2000-03-15 2004-10-20 Hanmi Pharm. Co., Ltd. Method of preparing a non-pharmaceutical grade clarithromycin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
US20010047089A1 (en) * 2000-01-04 2001-11-29 Judith Aronhime Preparation method of azithromycin dihydrate
EP1469008A1 (en) * 2000-03-15 2004-10-20 Hanmi Pharm. Co., Ltd. Method of preparing a non-pharmaceutical grade clarithromycin
WO2002044193A1 (en) * 2000-11-30 2002-06-06 Ercros Industrial, S.A. Method for obtaining azaerythromycin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT STN INTERNATIONAL, KARLSRUHE; 2003, QIN N.: "Study on the processes for preparation roxithromycin" *
GUANGDONG YAOXUE, vol. 13, no. 6, pages 23 - 24 *

Also Published As

Publication number Publication date
WO2007015265A2 (en) 2007-02-08

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