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WO2007011434A3 - Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors - Google Patents

Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors Download PDF

Info

Publication number
WO2007011434A3
WO2007011434A3 PCT/US2006/010668 US2006010668W WO2007011434A3 WO 2007011434 A3 WO2007011434 A3 WO 2007011434A3 US 2006010668 W US2006010668 W US 2006010668W WO 2007011434 A3 WO2007011434 A3 WO 2007011434A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
methods
hypothalamic
pituitary
hormones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/010668
Other languages
French (fr)
Other versions
WO2007011434A2 (en
Inventor
Christopher W Gregory
Maria E Kononov
Eric S Werdin
James Lester Barbee Iv
Carol Giamario
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Voyager Pharmaceutical Corp
Original Assignee
Voyager Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/180,667 external-priority patent/US20070015713A1/en
Priority claimed from US11/180,668 external-priority patent/US20060148697A1/en
Application filed by Voyager Pharmaceutical Corp filed Critical Voyager Pharmaceutical Corp
Publication of WO2007011434A2 publication Critical patent/WO2007011434A2/en
Publication of WO2007011434A3 publication Critical patent/WO2007011434A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods are provided for treating HPG axis-positive cancers, preventing or slowing proliferation of cells of HPG axis-positive cancer origin, preventing HPG axis-positive cancers in a patient at risk of contracting such cancers, preventing or inhibiting an upregulation of the cell cycle in HPG axis-positive cancer-derived cells in a patient, and decreasing the level of HPG axis-positive cancer-specific markers in a patient.
PCT/US2006/010668 2005-07-14 2006-03-22 Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors Ceased WO2007011434A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/180,667 US20070015713A1 (en) 2005-07-14 2005-07-14 Methods for treating prostate cancer
US11/180,668 US20060148697A1 (en) 2001-12-19 2005-07-14 Methods for treating and preventing brain cancers
US11/180,667 2005-07-14
US11/180,668 2005-07-14

Publications (2)

Publication Number Publication Date
WO2007011434A2 WO2007011434A2 (en) 2007-01-25
WO2007011434A3 true WO2007011434A3 (en) 2008-01-10

Family

ID=37669296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010668 Ceased WO2007011434A2 (en) 2005-07-14 2006-03-22 Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors

Country Status (1)

Country Link
WO (1) WO2007011434A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2090322A1 (en) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fsh receptor ligands for diagnosis and therapy of cancer
WO2010141630A1 (en) * 2009-06-03 2010-12-09 University Of Southern California Compositions and methods for treatment of cancer by disrupting the lh/lhr signaling pathway

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642274B1 (en) * 1999-09-09 2003-11-04 Gary W. Neal Methods and compositions for preventing and treating prostate disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642274B1 (en) * 1999-09-09 2003-11-04 Gary W. Neal Methods and compositions for preventing and treating prostate disorders

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALLEN ET AL.: "Combined treatment with ketoconazole and luteinising hormone releasing hormone analogue: a novel approach to resistant progressive prostatic cancer", BRITISH MEDICAL JOURNAL, vol. 287, December 1983 (1983-12-01), pages 1766 *
BOLLA ET AL.: "Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin", N. ENGL. J. MED., vol. 337, no. 5, July 1997 (1997-07-01), pages 295 - 300 *
COOK ET AL.: "Development of GnRH antagonists for prostate cancer: new approaches to treatment", THE ONCOLOGIST, vol. 5, April 2000 (2000-04-01), pages 162 - 168 *
DAWSON ET AL.: "A pilot trial of chemohormonal therapy for metastatic prostate carcinoma", CANCER, vol. 69, no. 1, January 1992 (1992-01-01), pages 213 - 218, XP055002314 *
FISHER ET AL.: "Abarelix Depot (A-D) monotherapy reduces PSA levels comparable to leuprolide acetate (L) plus bicalutamide (B): results of multicenter trial of rising PSA, advanced (D1/D2), neoadjuvant hormonal therapy (NHT), and intermittant hormonal therapy (IHT)....", PROC. AM. SOC. CLIN. ONCOL., vol. 20, 2001 *
UTRIANEN ET AL.: "Inhibition of DNA methylation increases follistatin expression and secretion in the human adrenocortical cell line NCI-H295R", J. OF ENDOCRINOLOGY, vol. 188, 2006, pages 305 - 310 *

Also Published As

Publication number Publication date
WO2007011434A2 (en) 2007-01-25

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