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WO2007010080A3 - Nuevos dendrímeros carbosilanos, su preparación y sus usos - Google Patents

Nuevos dendrímeros carbosilanos, su preparación y sus usos Download PDF

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Publication number
WO2007010080A3
WO2007010080A3 PCT/ES2006/070111 ES2006070111W WO2007010080A3 WO 2007010080 A3 WO2007010080 A3 WO 2007010080A3 ES 2006070111 W ES2006070111 W ES 2006070111W WO 2007010080 A3 WO2007010080 A3 WO 2007010080A3
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WIPO (PCT)
Prior art keywords
dendrimers
same
molecules
preparation
anionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2006/070111
Other languages
English (en)
French (fr)
Other versions
WO2007010080A2 (es
Inventor
La Mata De La Mata Francisc De
Ramirez Rafael Gomez
Serrano Juan Carlos Flores
Jesus Alcaniz Ernesto De
Lopez Paula Ortega
Fernandez Ma Angeles Munoz
Martin Jesus Francisco Bermejo
Lobera Ma Jesus Serramia
Gomez-Chacon Geronim Fernandez
Jimenez Louis Chonco
Mayoral Maria Isabel Clemente
Fuentes Jose Luis Jimenez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Alcala de Henares UAH
Original Assignee
Universidad de Alcala de Henares UAH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Alcala de Henares UAH filed Critical Universidad de Alcala de Henares UAH
Priority to AU2006271626A priority Critical patent/AU2006271626A1/en
Priority to US11/989,157 priority patent/US8603493B2/en
Priority to EP06778464A priority patent/EP1942130A4/en
Priority to CA002616092A priority patent/CA2616092A1/en
Priority to BRPI0613739-3A priority patent/BRPI0613739A2/pt
Priority to JP2008521998A priority patent/JP2009502765A/ja
Publication of WO2007010080A2 publication Critical patent/WO2007010080A2/es
Publication of WO2007010080A3 publication Critical patent/WO2007010080A3/es
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/48—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
    • C08G77/50—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages
    • C08G77/52—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nuevos dendrímeros carbosilanos, su preparación y sus usos. Los dendrímeros de la invención poseen en extremos de sus ramificaciones grupos amino primarios, secundarios, terciarios o cuaternarios. Entre sus posibles usos está la utilización como vehículos de transporte en la sangre de moléculas con carga aniónica como las moléculas de ácidos nucleicos, entre ellas los ODN y los ARNi, y otros fármacos amónicos con los que tengan capacidad para interaccionar, protegiéndolos de la interacción con proteínas del plasma y/o aumentando su tasa de penetración en células diana. En los casos en que la unión es perdurable, los dendrímeros de la invención pueden utilizarse para fijar moléculas amónicas a superficies. Sus usos incluyen también su administración como principios activos para la prevención o el tratamiento de enfermedades producidas por microorganismos con cuya estructura y/o ciclo vital interfieran.
PCT/ES2006/070111 2005-07-22 2006-07-21 Nuevos dendrímeros carbosilanos, su preparación y sus usos Ceased WO2007010080A2 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2006271626A AU2006271626A1 (en) 2005-07-22 2006-07-21 Novel carbosilane dendrimers, preparation method thereof and use of same
US11/989,157 US8603493B2 (en) 2005-07-22 2006-07-21 Carbosilane dendrimers, preparation method thereof and use of same
EP06778464A EP1942130A4 (en) 2005-07-22 2006-07-21 NEW CARBOSILAN DENDRIMERS, MANUFACTURING METHOD AND USE THEREOF
CA002616092A CA2616092A1 (en) 2005-07-22 2006-07-21 Novel carbosilane dendrimers, preparation method thereof and use of same
BRPI0613739-3A BRPI0613739A2 (pt) 2005-07-22 2006-07-21 dendrìmeros carbosilanos, seus processos de preparação, composições e kits compreendendo os mesmos, usos dos referidos compostos e composições na manufatura de drogas
JP2008521998A JP2009502765A (ja) 2005-07-22 2006-07-21 新規なカルボシランデンドリマー、その調製方法及びその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200501810 2005-07-22
ES200501810A ES2265291B1 (es) 2005-07-22 2005-07-22 Nuevos dendrimeros carbosilanos, su preparacion y sus usos.

Publications (2)

Publication Number Publication Date
WO2007010080A2 WO2007010080A2 (es) 2007-01-25
WO2007010080A3 true WO2007010080A3 (es) 2007-04-12

Family

ID=37669176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2006/070111 Ceased WO2007010080A2 (es) 2005-07-22 2006-07-21 Nuevos dendrímeros carbosilanos, su preparación y sus usos

Country Status (10)

Country Link
US (1) US8603493B2 (es)
EP (1) EP1942130A4 (es)
JP (1) JP2009502765A (es)
CN (1) CN101228212A (es)
AU (1) AU2006271626A1 (es)
BR (1) BRPI0613739A2 (es)
CA (1) CA2616092A1 (es)
ES (1) ES2265291B1 (es)
RU (1) RU2422474C2 (es)
WO (1) WO2007010080A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0804172A2 (pt) * 2008-07-15 2010-07-06 Pereira Lopes Jose Emilio Fehr compostos quìmicos formados a partir de nanoencapsulamentos e complexação de elementos
BR112012020870A2 (pt) * 2010-02-18 2017-02-07 Hospital General Universitário Gregorio dendrímeros carbosilanos e seu uso como antivarais.
ES2365685B2 (es) * 2010-03-25 2012-02-20 Universidad de Alcalá de Henares Dendrímeros carbosilanos con un núcleo polifenólico y su uso como antivirales.
ES2366286B1 (es) * 2010-03-29 2012-09-06 Nlife Therapeutics, S.L Nuevos dendrímeros amonio-fenóxido de estructura carbosilano y sus aplicaciones.
EP2474829A1 (en) * 2011-01-07 2012-07-11 Axetris AG Method for determination of molecular structures and functions
ES2392615B1 (es) * 2011-05-14 2013-10-18 Universidad De Málaga Estructuras dendríticas bapad, basadas en la conexión repetitiva de 2,2'-bis(aminoalquil)carboxiamidas; procedimiento de obtención y aplicaciones.
ES2392994B1 (es) * 2011-05-18 2013-10-24 Universidad De Alcalá Dendrimeros carbosilanos catiónicos obtenidos mediante "click chemistry", su preparación y sus usos
RU2014114931A (ru) 2011-09-16 2015-10-27 Нанокэа Текнолоджиз, Инк. Композиции соединений жасмонатов и способы применения
JP6578353B2 (ja) * 2014-09-23 2019-09-18 レール・リキード−ソシエテ・アノニム・プール・レテュード・エ・レクスプロワタシオン・デ・プロセデ・ジョルジュ・クロード Ｓｉ含有膜堆積用カルボシラン置換アミン前駆体及びその方法
KR20170125811A (ko) 2014-12-31 2017-11-15 나노케어 테크놀로지스 인코퍼레이티드 자스모네이트 유도체 및 그 조성물
TWI716333B (zh) 2015-03-30 2021-01-11 法商液態空氣喬治斯克勞帝方法研究開發股份有限公司 碳矽烷與氨、胺類及脒類之觸媒去氫耦合
TWI724141B (zh) 2016-03-23 2021-04-11 法商液態空氣喬治斯克勞帝方法硏究開發股份有限公司 形成含矽膜之組成物及其製法與用途
CN113769592B (zh) * 2021-09-18 2022-06-24 吉林大学 一种季铵化改性聚芳醚膜材料及其制备方法和应用

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EP1302475A1 (en) * 2000-06-30 2003-04-16 Japan Science and Technology Corporation Sugar chain-containing carbosilane dendrimer compounds, process for producing the same and verotoxin neutralizers and antiviral agents
WO2003033027A2 (en) * 2001-10-19 2003-04-24 University Of Strathclyde Dendrimers for use in targeted delivery
US20040009500A1 (en) * 2002-02-21 2004-01-15 Chimera Biotec Gmbh Items with activated surface used for immobilisation of macromolecules and procedures for the production of such items

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Also Published As

Publication number Publication date
ES2265291A1 (es) 2007-02-01
ES2265291B1 (es) 2008-03-01
EP1942130A4 (en) 2010-09-01
EP1942130A2 (en) 2008-07-09
BRPI0613739A2 (pt) 2011-02-01
CA2616092A1 (en) 2007-01-25
US20100034789A1 (en) 2010-02-11
RU2422474C2 (ru) 2011-06-27
CN101228212A (zh) 2008-07-23
JP2009502765A (ja) 2009-01-29
RU2008106762A (ru) 2009-08-27
AU2006271626A1 (en) 2007-01-25
US8603493B2 (en) 2013-12-10
WO2007010080A2 (es) 2007-01-25

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