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WO2007009143A3 - Verfahren zur herstellung nebivolol - Google Patents

Verfahren zur herstellung nebivolol Download PDF

Info

Publication number
WO2007009143A3
WO2007009143A3 PCT/AT2006/000303 AT2006000303W WO2007009143A3 WO 2007009143 A3 WO2007009143 A3 WO 2007009143A3 AT 2006000303 W AT2006000303 W AT 2006000303W WO 2007009143 A3 WO2007009143 A3 WO 2007009143A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing
separated
nebivolol
formula
producing nebivolol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2006/000303
Other languages
English (en)
French (fr)
Other versions
WO2007009143A2 (de
Inventor
Christian R Noe
Muhamed Jasic
Hermann Kollmann
Bodo Lachmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMACON - FORSCHUNG und BERATUNG GmbH
Pharmacon Forschung & Beratung GmbH
Original Assignee
PHARMACON - FORSCHUNG und BERATUNG GmbH
Pharmacon Forschung & Beratung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002615832A priority Critical patent/CA2615832A1/en
Priority to EA200800364A priority patent/EA200800364A1/ru
Priority to JP2008521739A priority patent/JP2009502750A/ja
Priority to MX2008000747A priority patent/MX2008000747A/es
Priority to US11/996,370 priority patent/US20080221340A1/en
Priority to AU2006272420A priority patent/AU2006272420A1/en
Priority to BRPI0613610-9A priority patent/BRPI0613610A2/pt
Priority to EP06760790A priority patent/EP1919888A2/de
Application filed by PHARMACON - FORSCHUNG und BERATUNG GmbH, Pharmacon Forschung & Beratung GmbH filed Critical PHARMACON - FORSCHUNG und BERATUNG GmbH
Publication of WO2007009143A2 publication Critical patent/WO2007009143A2/de
Publication of WO2007009143A3 publication Critical patent/WO2007009143A3/de
Priority to IL188777A priority patent/IL188777A0/en
Anticipated expiration legal-status Critical
Priority to NO20080823A priority patent/NO20080823L/no
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Gegenstand der Erfindung ist ein Verfahren zur Herstellung des razernischen Wirkstoffes Nebivolol, vorzugsweise als Hydrochlorid gemäß Formel (I) bei welchem diastereomere Cyanhydrine der allgemeinen Formel (II) hergestellt, getrennt und die getrennten Diastereomere nach einer Transformation, vorzugsweise einer teilweisen oder vollen Reduktion der Cyanogruppe oder einer Pinner-Verseifung, miteinander gekoppelt werden.
PCT/AT2006/000303 2005-07-19 2006-07-17 Verfahren zur herstellung nebivolol Ceased WO2007009143A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI0613610-9A BRPI0613610A2 (pt) 2005-07-19 2006-07-17 processo para preparação de nebivolol
JP2008521739A JP2009502750A (ja) 2005-07-19 2006-07-17 ネビボロールの製造方法
MX2008000747A MX2008000747A (es) 2005-07-19 2006-07-17 Metodo para producir nebivolol.
US11/996,370 US20080221340A1 (en) 2005-07-19 2006-07-17 Process for the Production of Nebivolol
AU2006272420A AU2006272420A1 (en) 2005-07-19 2006-07-17 Method for producing nebivolol
CA002615832A CA2615832A1 (en) 2005-07-19 2006-07-17 Method for producing nebivolol
EA200800364A EA200800364A1 (ru) 2005-07-19 2006-07-17 Способ получения небиволола
EP06760790A EP1919888A2 (de) 2005-07-19 2006-07-17 Verfahren zur herstellung nebivolol
IL188777A IL188777A0 (en) 2005-07-19 2008-01-15 Method for producing nebivolol
NO20080823A NO20080823L (no) 2005-07-19 2008-02-15 Fremgangsmate for fremstilling av nebivolol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1214/2005 2005-07-19
AT0121405A AT502220A1 (de) 2005-07-19 2005-07-19 Verfahren zur herstellung von nebivolol

Publications (2)

Publication Number Publication Date
WO2007009143A2 WO2007009143A2 (de) 2007-01-25
WO2007009143A3 true WO2007009143A3 (de) 2007-04-05

Family

ID=37450808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2006/000303 Ceased WO2007009143A2 (de) 2005-07-19 2006-07-17 Verfahren zur herstellung nebivolol

Country Status (15)

Country Link
US (1) US20080221340A1 (de)
EP (1) EP1919888A2 (de)
JP (1) JP2009502750A (de)
KR (1) KR20080027368A (de)
CN (1) CN101243062A (de)
AT (1) AT502220A1 (de)
AU (1) AU2006272420A1 (de)
BR (1) BRPI0613610A2 (de)
CA (1) CA2615832A1 (de)
EA (1) EA200800364A1 (de)
IL (1) IL188777A0 (de)
MX (1) MX2008000747A (de)
NO (1) NO20080823L (de)
WO (1) WO2007009143A2 (de)
ZA (1) ZA200800963B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE533752T1 (de) 2008-09-08 2011-12-15 Cadila Pharmaceuticals Ltd Verbesserter herstellungsprozess für nebivolol- hydrocholorid
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) * 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
CN102190647A (zh) * 2010-03-12 2011-09-21 浙江海翔药业股份有限公司 一种奈比洛尔的中间体的制备方法
CN113563295A (zh) 2015-05-19 2021-10-29 浙江奥翔药业股份有限公司 奈必洛尔的合成方法及其中间体化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145067A2 (de) * 1983-12-05 1985-06-19 Janssen Pharmaceutica N.V. 2,2'-Iminobisäthanol-Derivate
CN1683355A (zh) * 2005-03-03 2005-10-19 浙江医药股份有限公司新昌制药厂 Dl－奈必洛尔及其盐酸盐的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145067A2 (de) * 1983-12-05 1985-06-19 Janssen Pharmaceutica N.V. 2,2'-Iminobisäthanol-Derivate
CN1683355A (zh) * 2005-03-03 2005-10-19 浙江医药股份有限公司新昌制药厂 Dl－奈必洛尔及其盐酸盐的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200616, Derwent World Patents Index; AN 2006-146512, XP002410014 *
JOHANNES, CHARLES W. ET AL: "Zr-Catalyzed Kinetic Resolution of Allylic Ethers and Mo-Catalyzed Chromene Formation in Synthesis. Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 120(33), 8340-8347 CODEN: JACSAT; ISSN: 0002-7863, 1998, XP002410010 *

Also Published As

Publication number Publication date
KR20080027368A (ko) 2008-03-26
EA200800364A1 (ru) 2008-06-30
CA2615832A1 (en) 2007-01-25
AU2006272420A1 (en) 2007-01-25
MX2008000747A (es) 2008-04-14
EP1919888A2 (de) 2008-05-14
US20080221340A1 (en) 2008-09-11
ZA200800963B (en) 2009-08-26
JP2009502750A (ja) 2009-01-29
WO2007009143A2 (de) 2007-01-25
AT502220A1 (de) 2007-02-15
IL188777A0 (en) 2008-08-07
CN101243062A (zh) 2008-08-13
BRPI0613610A2 (pt) 2011-01-18
NO20080823L (no) 2008-04-02

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