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WO2007067819A3 - Détection moléculaire optique - Google Patents

Détection moléculaire optique Download PDF

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Publication number
WO2007067819A3
WO2007067819A3 PCT/US2006/047244 US2006047244W WO2007067819A3 WO 2007067819 A3 WO2007067819 A3 WO 2007067819A3 US 2006047244 W US2006047244 W US 2006047244W WO 2007067819 A3 WO2007067819 A3 WO 2007067819A3
Authority
WO
WIPO (PCT)
Prior art keywords
reflected
light
molecular detection
reflected beam
calibration structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/047244
Other languages
English (en)
Other versions
WO2007067819A2 (fr
Inventor
Bo Pi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PRECISION HUMAN BIOLABORATORY
PREC HUMAN BIOLABORATORY
Original Assignee
PRECISION HUMAN BIOLABORATORY
PREC HUMAN BIOLABORATORY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PRECISION HUMAN BIOLABORATORY, PREC HUMAN BIOLABORATORY filed Critical PRECISION HUMAN BIOLABORATORY
Priority to US12/305,950 priority Critical patent/US8673650B2/en
Publication of WO2007067819A2 publication Critical patent/WO2007067819A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007067819A3 publication Critical patent/WO2007067819A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction

Landscapes

  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)

Abstract

La présente invention concerne la détection optique de molécules utilisant une biopuce comportant au moins une aire d'immobilisation de réactifs conçue pour recevoir un ou plusieurs réactifs et au moins une structure de calibrage avec une hauteur prédéterminée pour définir une hauteur de référence pour la mesure optique. Lorsque la structure de calibrage est éclairée par un faisceau de lumière de sonde, un premier faisceau de lumière réfléchi est réfléchi par la structure de calibrage, et un second faisceau de lumière réfléchi est réfléchi par l'aire d’immobilisation de réactif. Le premier faisceau réfléchi et le second faisceau réfléchi sont comparés pour déterminer une hauteur dans l'aire d’immobilisation de réactif.
PCT/US2006/047244 2005-12-09 2006-12-11 Détection moléculaire optique Ceased WO2007067819A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/305,950 US8673650B2 (en) 2005-12-09 2006-12-11 Optical molecular detection

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US74882405P 2005-12-09 2005-12-09
US60/748,824 2005-12-09
US78432206P 2006-03-21 2006-03-21
US60/784,322 2006-03-21
US79658506P 2006-05-01 2006-05-01
US60/796,585 2006-05-01

Publications (2)

Publication Number Publication Date
WO2007067819A2 WO2007067819A2 (fr) 2007-06-14
WO2007067819A3 true WO2007067819A3 (fr) 2009-04-09

Family

ID=38123576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/047244 Ceased WO2007067819A2 (fr) 2005-12-09 2006-12-11 Détection moléculaire optique

Country Status (2)

Country Link
US (1) US8673650B2 (fr)
WO (1) WO2007067819A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158374B1 (en) 2006-09-05 2012-04-17 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
JP5496445B2 (ja) * 2007-06-08 2014-05-21 ルネサスエレクトロニクス株式会社 半導体装置の製造方法
EP2329260A4 (fr) * 2008-03-04 2011-08-03 Ridge Diagnostics Inc Diagnostic et surveillance de troubles dépressifs basés sur une pluralité de panels de biomarqueurs
CA2718273A1 (fr) * 2008-03-12 2009-09-17 Ridge Diagnostics, Inc. Biomarqueurs d'inflammation pour la surveillance de troubles de depression
CA2744151A1 (fr) 2008-11-18 2010-05-27 Ridge Diagnostics, Inc. Biomarqueurs de syndrome metabolique et d'axe hpa pour un trouble depressif majeur
JP5675771B2 (ja) 2009-04-01 2015-02-25 リッジ ダイアグノスティックス，インコーポレイテッド 精神神経疾患の治療をモニタリングするためのバイオマーカー
US9063092B2 (en) * 2009-09-14 2015-06-23 Koninklijke Philips N.V. Sensing system for sensing a substance in a fluid
GB201011459D0 (en) * 2010-07-07 2010-08-25 Melys Diagnostics Ltd Optical element, assembly and method for determining analyte concentration
US10488393B2 (en) 2010-09-30 2019-11-26 Robert Bosch Gmbh Device and method for self-referenced confidence test
WO2012069988A1 (fr) * 2010-11-25 2012-05-31 Koninklijke Philips Electronics N.V. Cartouche pour examiner un échantillon
DE102011083555B4 (de) * 2011-09-27 2013-10-10 Aspre Ag Analyseverfahren und Analysevorrichtung
EP2783215B1 (fr) * 2011-11-22 2018-04-25 Robert Bosch GmbH Procédé de test de confiance auto-référencé
JP6402273B1 (ja) * 2018-05-18 2018-10-10 大塚電子株式会社 光学測定装置及び光学測定方法
EP3935370A1 (fr) * 2019-03-08 2022-01-12 Ecole Polytechnique Federale De Lausanne (Epfl) Substrat de mesure de luminescence basée sur la surface
GB202008287D0 (en) 2020-06-02 2020-07-15 Kostarelos Kostas Methods of determining cancer
GB202102399D0 (en) 2021-02-19 2021-04-07 Univ Manchester Methods of determining alzheimer's disease

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US6159681A (en) * 1997-05-28 2000-12-12 Syntrix Biochip, Inc. Light-mediated method and apparatus for the regional analysis of biologic material
US20020088919A1 (en) * 2001-01-11 2002-07-11 Hiroshi Muramatsu Light probe microscope
US6738141B1 (en) * 1999-02-01 2004-05-18 Vir A/S Surface plasmon resonance sensor
US20040151629A1 (en) * 2003-01-31 2004-08-05 Grant Pease Microfluidic device with thin-film electronic devices
US6882420B2 (en) * 2000-07-11 2005-04-19 Maven Technologies, Llc Apparatus and method for imaging

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US6159681A (en) * 1997-05-28 2000-12-12 Syntrix Biochip, Inc. Light-mediated method and apparatus for the regional analysis of biologic material
US6738141B1 (en) * 1999-02-01 2004-05-18 Vir A/S Surface plasmon resonance sensor
US6882420B2 (en) * 2000-07-11 2005-04-19 Maven Technologies, Llc Apparatus and method for imaging
US20020088919A1 (en) * 2001-01-11 2002-07-11 Hiroshi Muramatsu Light probe microscope
US20040151629A1 (en) * 2003-01-31 2004-08-05 Grant Pease Microfluidic device with thin-film electronic devices

Also Published As

Publication number Publication date
US20100144052A1 (en) 2010-06-10
WO2007067819A2 (fr) 2007-06-14
US8673650B2 (en) 2014-03-18

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