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WO2007060568A3 - Dispositif de detection magnetique dote d’une chambre d’echantillonnage - Google Patents

Dispositif de detection magnetique dote d’une chambre d’echantillonnage Download PDF

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Publication number
WO2007060568A3
WO2007060568A3 PCT/IB2006/054217 IB2006054217W WO2007060568A3 WO 2007060568 A3 WO2007060568 A3 WO 2007060568A3 IB 2006054217 W IB2006054217 W IB 2006054217W WO 2007060568 A3 WO2007060568 A3 WO 2007060568A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
sensor device
magnetic sensor
excitation wires
sample chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/054217
Other languages
English (en)
Other versions
WO2007060568A2 (fr
Inventor
Josephus Arnoldus Henr Kahlman
Haris Duric
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of WO2007060568A2 publication Critical patent/WO2007060568A2/fr
Publication of WO2007060568A3 publication Critical patent/WO2007060568A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

L’invention concerne un dispositif de détection magnétique (10) comprenant deux fils d’excitation (11, 13) servant à générer des premier et deuxième champs magnétiques (B1, B2) dans des première et deuxième régions d’investigation (5a, 5b) respectives. Un détecteur (12) à magnétorésistance géante (GMR) disposé au milieu entre les fils d’excitation (11, 13) détecte les champs parasites (B') générés par des billes aimantées (2) qui s’associent dans l’une (5a) des régions d’investigation. Lorsque les fils d’excitation (11, 13) sont parcourus de courants (I1, 12) circulant en sens inverse, les composantes des premier et deuxième champs magnétiques (B1, B2) dans la direction de détection (D) du détecteur à GMR (12) se neutralisent dans ledit détecteur (12), en minimisant ainsi les interférences dues à la diaphonie. Une autre (5b) des régions d’investigation comprend une zone d’exclusion empêchant les billes aimantées (2) de s’y associer et donc de neutraliser de la même façon les champs parasites (B').
PCT/IB2006/054217 2005-11-23 2006-11-13 Dispositif de detection magnetique dote d’une chambre d’echantillonnage Ceased WO2007060568A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111136.7 2005-11-23
EP05111136 2005-11-23

Publications (2)

Publication Number Publication Date
WO2007060568A2 WO2007060568A2 (fr) 2007-05-31
WO2007060568A3 true WO2007060568A3 (fr) 2007-09-07

Family

ID=38006560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/054217 Ceased WO2007060568A2 (fr) 2005-11-23 2006-11-13 Dispositif de detection magnetique dote d’une chambre d’echantillonnage

Country Status (1)

Country Link
WO (1) WO2007060568A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053902A2 (fr) * 2007-10-25 2009-04-30 Koninklijke Philips Electronics N. V. Dispositif à capteur pour particules cibles dans un échantillon
EP2219033B1 (fr) 2008-12-30 2016-05-25 MicroCoat Biotechnologie GmbH Dispositif, instrument et procédé de détection des analytes étiquetés magnétiquement
DE102009047801B4 (de) * 2009-09-30 2014-06-12 Siemens Aktiengesellschaft Durchflusskammer mit Zellleiteinrichtung
DE102009047793A1 (de) * 2009-09-30 2011-04-07 Siemens Aktiengesellschaft Durchflusskammer mit GMR-Sensor und Zellleiteinrichtung
WO2012035462A1 (fr) * 2010-09-17 2012-03-22 Koninklijke Philips Electronics N.V. Système magnétique pour l'attraction des particules dans une pluralité de chambres
DE102013200927A1 (de) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen
CN107110664B (zh) 2014-09-26 2020-03-17 伯恩斯公司 用于有效平衡/消除磁传感器中的磁干扰的系统和方法
CN107796865B (zh) 2016-09-05 2021-05-25 财团法人工业技术研究院 生物分子磁传感器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010542A2 (fr) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. Detecteur de particules magnetiques monte sur puce et caracterise par un rsb ameliore
WO2005010543A1 (fr) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. Dispositif du type capteur magnetique monte sur puce et caracterise par une suppression de la diaphonie
WO2005073695A1 (fr) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Procede et dispositif de spectroscopie par resonance magnetique realise sur la puce
WO2005116661A1 (fr) * 2004-05-24 2005-12-08 Koninklijke Philips Electronics N.V. Capteur magneto-resistif pour sondage de profondeur tres sensible

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010542A2 (fr) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. Detecteur de particules magnetiques monte sur puce et caracterise par un rsb ameliore
WO2005010543A1 (fr) * 2003-07-30 2005-02-03 Koninklijke Philips Electronics N.V. Dispositif du type capteur magnetique monte sur puce et caracterise par une suppression de la diaphonie
WO2005073695A1 (fr) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Procede et dispositif de spectroscopie par resonance magnetique realise sur la puce
WO2005116661A1 (fr) * 2004-05-24 2005-12-08 Koninklijke Philips Electronics N.V. Capteur magneto-resistif pour sondage de profondeur tres sensible

Also Published As

Publication number Publication date
WO2007060568A2 (fr) 2007-05-31

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