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WO2007051068A3 - Compositions and methods for the treatment of aberrant stress response disorders - Google Patents

Compositions and methods for the treatment of aberrant stress response disorders Download PDF

Info

Publication number
WO2007051068A3
WO2007051068A3 PCT/US2006/042580 US2006042580W WO2007051068A3 WO 2007051068 A3 WO2007051068 A3 WO 2007051068A3 US 2006042580 W US2006042580 W US 2006042580W WO 2007051068 A3 WO2007051068 A3 WO 2007051068A3
Authority
WO
WIPO (PCT)
Prior art keywords
stress response
treatment
methods
compositions
response disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/042580
Other languages
French (fr)
Other versions
WO2007051068A2 (en
Inventor
Amelia Gallitano-Mendel
Jeffrey D Milbrandt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of WO2007051068A2 publication Critical patent/WO2007051068A2/en
Publication of WO2007051068A3 publication Critical patent/WO2007051068A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to animal models of stress response disorders, methods of using the same to screen for agents useful for the treatment of stress response disorders, and agents so identified.
PCT/US2006/042580 2005-10-28 2006-10-30 Compositions and methods for the treatment of aberrant stress response disorders Ceased WO2007051068A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73165505P 2005-10-28 2005-10-28
US60/731,655 2005-10-28

Publications (2)

Publication Number Publication Date
WO2007051068A2 WO2007051068A2 (en) 2007-05-03
WO2007051068A3 true WO2007051068A3 (en) 2007-06-28

Family

ID=37968630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042580 Ceased WO2007051068A2 (en) 2005-10-28 2006-10-30 Compositions and methods for the treatment of aberrant stress response disorders

Country Status (1)

Country Link
WO (1) WO2007051068A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030237105A1 (en) * 2002-06-25 2003-12-25 Allen Keith D. MGLUR5 metabotropic glutamate receptor gene disruptions, and compositions and methods related thereto
US20040220178A1 (en) * 1999-06-15 2004-11-04 Robichaud Albert J. Substituted heterocycle fused gamma-carbolines
US20050158733A1 (en) * 2003-06-30 2005-07-21 Gerber David J. EGR genes as targets for the diagnosis and treatment of schizophrenia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220178A1 (en) * 1999-06-15 2004-11-04 Robichaud Albert J. Substituted heterocycle fused gamma-carbolines
US20030237105A1 (en) * 2002-06-25 2003-12-25 Allen Keith D. MGLUR5 metabotropic glutamate receptor gene disruptions, and compositions and methods related thereto
US20050158733A1 (en) * 2003-06-30 2005-07-21 Gerber David J. EGR genes as targets for the diagnosis and treatment of schizophrenia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SALLINEN J. ET AL.: "Adrenergic Alpha2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice", JOURNAL OF NEUROSCIENCE, vol. 18, no. 8, 15 April 1998 (1998-04-15), pages 3035 - 3042, XP000918297 *

Also Published As

Publication number Publication date
WO2007051068A2 (en) 2007-05-03

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