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WO2007049278A3 - A method for preparing liposomes and uses thereof - Google Patents

A method for preparing liposomes and uses thereof Download PDF

Info

Publication number
WO2007049278A3
WO2007049278A3 PCT/IL2006/001229 IL2006001229W WO2007049278A3 WO 2007049278 A3 WO2007049278 A3 WO 2007049278A3 IL 2006001229 W IL2006001229 W IL 2006001229W WO 2007049278 A3 WO2007049278 A3 WO 2007049278A3
Authority
WO
WIPO (PCT)
Prior art keywords
liposome
liposomes
lipid
forming lipid
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2006/001229
Other languages
French (fr)
Other versions
WO2007049278A2 (en
Inventor
Yechezkel Barenholz
Olga Garbuzenko
Keren Barhum
Gilbert Grant
Boris Piskoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, New York University NYU filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Priority to JP2008537312A priority Critical patent/JP2009513621A/en
Priority to CA002627657A priority patent/CA2627657A1/en
Priority to EP06809790A priority patent/EP1954243A2/en
Priority to AU2006307460A priority patent/AU2006307460A1/en
Publication of WO2007049278A2 publication Critical patent/WO2007049278A2/en
Publication of WO2007049278A3 publication Critical patent/WO2007049278A3/en
Anticipated expiration legal-status Critical
Priority to IL191074A priority patent/IL191074A0/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

The present invention provides a simplified and cost effective method preparing liposomes, the method comprising providing a dry liposome forming lipid or a dry mixture comprising a liposome forming lipid; dissolving the liposome forming lipid or said mixture comprising a liposome forming lipid of step (a) with a protic organic solvent to form a solution or dispersion of said lipid; and adding the solution or dispersion of step (b) to ions containing aqueous solution to form a liposome suspension; wherein the liposomes are capable of encapsulating an agent at a ratio between the agent and the liposome forming lipid being greater than 1.0. The method is characterized in that it does not involve drying the solution or dispersion to form a dry lipid film; and/or down-sizing liposomes in said liposome suspension to form small unilamellar vesicles (SUV). The thus formed liposomes may then be used for loading thereto an active agent, such as amphiphatic weak acid/base drugs.
PCT/IL2006/001229 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof Ceased WO2007049278A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008537312A JP2009513621A (en) 2005-10-26 2006-10-26 Method for preparing liposomes and use thereof
CA002627657A CA2627657A1 (en) 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof
EP06809790A EP1954243A2 (en) 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof
AU2006307460A AU2006307460A1 (en) 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof
IL191074A IL191074A0 (en) 2005-10-26 2008-04-27 A method for preparing liposomes and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73004505P 2005-10-26 2005-10-26
US60/730,045 2005-10-26

Publications (2)

Publication Number Publication Date
WO2007049278A2 WO2007049278A2 (en) 2007-05-03
WO2007049278A3 true WO2007049278A3 (en) 2007-09-13

Family

ID=37968217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001229 Ceased WO2007049278A2 (en) 2005-10-26 2006-10-26 A method for preparing liposomes and uses thereof

Country Status (5)

Country Link
EP (1) EP1954243A2 (en)
JP (1) JP2009513621A (en)
AU (1) AU2006307460A1 (en)
CA (1) CA2627657A1 (en)
WO (1) WO2007049278A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1812766A (en) 2003-04-25 2006-08-02 宾州研究基金会 Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
AU2009331158A1 (en) * 2008-12-24 2010-07-01 Biomedcore Inc. Method for producing liposome and method for dissolving cholesterol
EP2531175A2 (en) * 2010-02-01 2012-12-12 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Liposomes comprising amphipathic drugs and method for their preparation
EP2632553B1 (en) 2010-10-28 2020-01-01 Pacira Pharmaceuticals, Inc. A sustained release formulation of a non-steroidal anti-inflammatory drug
BR112013024663A2 (en) * 2011-03-25 2016-12-20 Terumo Corp long-term controlled release liposome composition and method for producing the same
WO2014046191A1 (en) 2012-09-21 2014-03-27 テルモ株式会社 Local-anesthetic long-lasting sustained-release liposome preparation
CA2906149C (en) 2013-03-15 2020-09-15 Taiwan Liposome Company, Ltd. Controlled drug release liposome composition
US10220095B2 (en) 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
CN104906586A (en) * 2014-03-10 2015-09-16 中国科学院上海药物研究所 Irinotecan hydrochloride composite phospholipid composition, preparation method and applications thereof
JP6866060B2 (en) * 2014-10-27 2021-04-28 花王株式会社 Manufacturing method of refined tea extract
DK3302435T3 (en) 2015-05-26 2023-06-06 Plumb Pharmaceuticals Inc LIPO RECHARGING
CN106619516B (en) * 2016-10-10 2020-07-03 常州金远药业制造有限公司 Preparation method of small molecule targeted drug liposome preparation
EP3541815A4 (en) 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. MULTIVESICULAR LIPOSOME FORMULATION WITH ZINC MELOXICAM COMPLEX MICROPARTICLES AND METHOD FOR THE PRODUCTION THEREOF
IL272187B (en) * 2017-07-24 2022-08-01 Pharmosa Biopharm Inc Liposome compositions comprising weak acid drugs and uses thereof
PT3790554T (en) * 2018-05-07 2026-01-13 Pharmosa Biopharm Inc Pharmaceutical composition for controlled release of treprostinil

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3335701A1 (en) * 1982-10-04 1984-04-05 Lipoderm Pharmaceuticals Ltd., Halifax, Nova Scotia METHOD FOR PRODUCING LARGE MULTILAMELLAR LIPID BLADES
FR2550706A1 (en) * 1983-08-17 1985-02-22 Sterwin Ag
EP0260241A1 (en) * 1986-09-12 1988-03-16 Aktiebolaget Draco A new system for administration of liposomes to mammals
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
WO1996010393A1 (en) * 1994-09-30 1996-04-11 Bracco Research S.A. Liposomes with enhanced entrapment capacity, method and use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3335701A1 (en) * 1982-10-04 1984-04-05 Lipoderm Pharmaceuticals Ltd., Halifax, Nova Scotia METHOD FOR PRODUCING LARGE MULTILAMELLAR LIPID BLADES
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
FR2550706A1 (en) * 1983-08-17 1985-02-22 Sterwin Ag
EP0260241A1 (en) * 1986-09-12 1988-03-16 Aktiebolaget Draco A new system for administration of liposomes to mammals
WO1996010393A1 (en) * 1994-09-30 1996-04-11 Bracco Research S.A. Liposomes with enhanced entrapment capacity, method and use

Also Published As

Publication number Publication date
EP1954243A2 (en) 2008-08-13
AU2006307460A1 (en) 2007-05-03
CA2627657A1 (en) 2007-05-03
WO2007049278A2 (en) 2007-05-03
JP2009513621A (en) 2009-04-02

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